An Unusual Case of Carcinoma Erysipelatoides Originating from Gastric Adenocarcinoma

Choi, Won Jun; Jue, Mihn‐Sook; Ko, Joo Yeon; Ro, Young Suck

doi:10.5021/ad.2011.23.3.375

Cited by 12 publications

(27 citation statements)

References 8 publications

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“…However, some skin cancers may also contain SRCs (squamous cell carcinoma, basal cell carcinoma, primary cutaneous SRC carcinoma of eccrine or apocrine origin, melanocytic tumours (nevi or melanomas), liposarcomas, hydradenomas, cylindromas, lymphomas, and the atrophic variant of mycosis fungoides, which could constitute potential alternative diagnosis. 3,4 Moreover, the particular immunochemistry profile found from the skin biopsy was also identified in other carcinomas such as cholangiocarcinoma, 5 malignant mesothelioma, 5,6 breast carcinoma, 5,7 ovarian carcinoma 5 and endometrial adenocarcinoma 5,8 which could be differentiated by their own specific immunochemistry markers.…”

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confidence: 87%

“…2 The same location has been exceptionally described in 1984, namely connubial melanoma of the choroid. 3 Many other descriptions of melanoma in spouses are reported. 4,5 Because of them, our real question is whether the reason of the melanoma is coincidental or the expression of exposure to the same risk factors.…”

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confidence: 99%

“…6 In fact, there is no evidence confirming that connubial melanoma could derive from the exposure to the same environmental risk factors. [1][2][3][4][5][6][7] Although…”

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confidence: 99%

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Cervical cutaneous sclerosis: the stomach is not far from the skin

Gauci

Hua

Ortonne

et al. 2019

Acad Dermatol Venereol

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confidence: 87%

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confidence: 99%

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Cervical cutaneous sclerosis: the stomach is not far from the skin

Gauci

Hua

Ortonne

et al. 2019

Acad Dermatol Venereol

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“…Signet ring cells are most frequently associated with stomach cancer but can arise from other tissues including the bladder, breast, colon, and lung. 3 Thus, the presence of signet ring cells in a skin biopsy specimen suggests Figure 1 (a, b) Clinical manifestation of metastatic gastric carcinoma in a 73-year-old woman. Pruritic, well-demarcated, erythematous to brownish, slightly indurated, edematous plaque is apparent on the left side of the neck, chest wall and left arm metastatic SRCC from the gastrointestinal tract, bladder, breast, or lung.…”

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confidence: 99%

“…However, cutaneous neoplasms that may contain signet ring cells, including non-Hodgkin's lymphoma, primary cutaneous SRCC of eccrine or apocrine origin, primary cutaneous signet ring basal cell carcinoma, and squamous cell carcinoma, must be excluded. 3 The diagnosis of cutaneous metastasis is important because the disease has a poor prognosis. Therefore, a dermatologist examining new unusual skin lesions in a patient with a history of malignancy should consider the possibility of unusual metastases to the skin and subsequently obtain a skin biopsy from the suspicious lesion.…”

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confidence: 99%

Metastatic gastric signet ring cell carcinoma clinically mimicking radiation recall dermatitis

et al. 2014

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A 53-year-old woman presented to the dermatology clinic with a history of a bilateral circular orange discoloration around the upper and lower eyelids. On physical examination, the orange flat plaque lesions involved both the upper and lower eyelids, resembling a pair of circles. The lesions of the medial side of both of the upper eyelids were particularly large (Fig. 1a,b). There was orange discoloration of the palms (Fig. 1c) and soles. The sclerae and oral mucosa appeared normal. She had no organomegaly. We learned that the patient ate too much carrot and orange over the last two months, which underlined her anamnesis. In the light of the clinical exam and anamnesis, the patient was diagnosed xanthelasmas and carotenoderma. Laboratory tests were evaluated, and the total cholesterol, high-density lipoprotein cholesterol, and triglyceride levels were 258 mg/dl (range 50-200 mg/dl), 35.2 mg/dl (range 35-55 mg/dl), and 137 mg/dl (0-150 mg/dl). Respectively, the total cholesterol level was in the higher than normal range.Xanthelasma is the most common type of cutaneous xanthoma. They may indicate hyperlipidemia, but 25-70% of patients in most cases are normolipidemic. Histologically, foamy histiocytes occur in the perivascular area, mostly in the middle and superficial layers of the dermis. They contain membrane-bound lipid vacuoles, cholesterol crystals, lysosomes, and residual bodies. 1 Carotenoderma is a phenomenon characterized by orange pigmentation of the skin, resulting from carotene deposition mainly in the stratum corneum, in sweat and in sebum, such as the nasolabial folds, palms, and soles. The sclerae are not affected, and this helps to distinguish carotenoderma from jaundice. 2 Both diseases are distinct clinical manifestations. Carotene exclusively accumulates in the regions such as thick stratum corneum, where the proportion of sebum is high. 2 In this case, the orange ring occurred due to the accumulation of carotene in xanthelasma lesions, where the amount of lipid is rather high.

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Cutaneous Markers of Internal Malignancy

Emtestam

Sartorius

2016

Rook's Textbook of Dermatology, Ninth Edition

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Different types of skin change are associated with internal malignancy. Tumour may spread to the skin from adjacent tissues, or may be deposited in the skin by metastasis. More typically dermatologists are called upon to assess paraneoplastic phenomena involving the skin, or to comment on dermatoses which are known, in some cases, to be markers of internal malignancy. Certain rare, inherited conditions, which have skin manifestations, carry a risk for the development of internal neoplasia. In other paraneoplastic settings, dysfunction of physiological activities, such as flushing or clotting, can lead the dermatologist to suspect an associated cancer. Potential cutaneous markers of internal malignancy vary in their reliability for predicting underlying neoplasia. The extent and intensity of the investigations for malignancy should therefore be tempered by a general assessment of the patient.

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An Unusual Case of Carcinoma Erysipelatoides Originating from Gastric Adenocarcinoma

Cited by 12 publications

References 8 publications

Cervical cutaneous sclerosis: the stomach is not far from the skin

Cervical cutaneous sclerosis: the stomach is not far from the skin

Metastatic gastric signet ring cell carcinoma clinically mimicking radiation recall dermatitis

Cutaneous Markers of Internal Malignancy

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