An Unusual Case of Aortic Stenosis in Systemic Sclerosis

Kagalwalla, Mustafa; Gupta, Madhulika A.; Malwi, Umme Haani; Hussain, Nazia

doi:10.7759/cureus.1303

Cited by 1 publication

(1 citation statement)

References 9 publications

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“…In Table 4, we summarized the main articles concerning valvular disease in SSc patients. On the whole, 21 articles were case reports 45–65 ; 11 were case series, 22,24–28,30–32,40,42 which often included few patients; and 3 studies were based on large cohorts 38,43,44 . Overall, we found 9 controlled studies 23,29,33–37,39,41 …”

Section: Review Of the Literaturementioning

confidence: 95%

Heart Valve Abnormalities in Systemic Sclerosis Patients

et al. 2020

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BackgroundSystemic sclerosis (SSc) is a chronic autoimmune disease that is characterized by vasculopathy and fibrosis of the skin and visceral organs. Heart valve diseases are poorly described and generally not considered typical of SSc. We aimed to describe valvular abnormalities in a multicenter cohort of SSc patients and to investigate their correlation with SSc features.MethodsWe recruited 118 consecutive SSc patients (male/female, 14/104; mean age, 55.2 ± 12.1 years) in 3 rheumatology centers in Sicily, Italy, from January to October 2019.ResultsMitral and tricuspid valve insufficiency was found in 85% and 91% of patients, respectively; regurgitations were generally mild and never severe. Mitral stenosis was rare (2%), and tricuspid stenosis was not observed. Sclerosis and calcification were present in 30% of mitral valves and in only 4% of tricuspid valves. The aortic valve was affected in 25% of cases, and it generally presented as regurgitation or sclerosis, whereas stenosis was rare (3%). Finally, 11% of SSc patients showed regurgitation of the pulmonary valve. No specific associations between SSc features and valve alterations were found.ConclusionsValvular diseases are frequently observed in SSc patients, with a predominant pattern of valvular regurgitations. Therefore, echocardiography should be routinely performed during SSc patient follow-up, considering the potential influence of additional cardiac involvement in the prognosis of these patients.

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