An Unusual Association: Takayasu’s Arteritis and Tubulointerstitial Nephritis and Uveitis Syndrome

Abstract

The coexistence of two immune-mediated diseases in the same patient is unusual. Takayasu’s arteritis (TA), which is a chronic granulomatous vasculitis, was discovered in a 47-year-old woman followed for tubulointerstitial nephritis and uveitis syndrome (TINU syndrome). We present the first case of this association.

Association between Tubulointerstitial Nephritis and Uveitis Syndrome and Small-Vessel CNS Vasculitis: A Case of Polyautoimmunity

“…However, in these patients the preceding medication with immunosuppressants as well as biologicals for treatment of IBD are discussed as possible triggers of vasculitis apart from the underlying IBD (23). Regarding TINU syndrome there is a study of concomitant diagnosis of Takayasu arteritis (24). Leaving TINU syndrome and CNS vasculitis aside further ADs like autoimmune thyroid disease or Sjögren's syndrome (25) are described to have higher associations with another AD than the background prevalence.…”

“…23 Regarding TINU syndrome, there is a study of concomitant diagnosis of Takayasu arteritis. 24 Leaving TINU syndrome and CNS vasculitis aside, further ADs such as autoimmune thyroid disease or Sjögren's syndrome 25 are described to have higher associations with another AD than the background prevalence. Thus, the terms polyautoimmunity (two concomitant ADs) and multiple autoimmune syndrome (three or more concomitant ADs) were created.…”