An unusual association of three autoimmune disorders: celiac disease, systemic lupus erythematosus and Hashimoto’s thyroiditis

Abstract

Autoimmune disorders are known to be more frequent in women and often associated each others, but it is rare to see multiple autoimmune diseases in a single patient. Recently, the concept of multiple autoimmune syndrome has been introduced to describe patients with at least three autoimmune diseases. We describe a case of a young man with a clinical history of psychiatric symptoms and celiac disease (CD) who was diagnosed to have other two autoimmune disorders: systemic lupus erythematosus (SLE) and Hashimoto’s thyroiditis. This case is unusual upon different patterns: the rare combination of the three autoimmune diseases, their appearance in a man and the atypical onset of the diseases with psychiatric symptoms likely to be related either to CD or to SLE.

Immune Mediated Diseases in Patients With Celiac Disease and Their Relatives: A Comparative Study of Age and Sex

“…Both females were received treatments for hypothyroidism, and one of them developed DH. Interestingly, three or four IMDs occurring in the same patient is a rare association (29) . Compared with controls, patients with CD were 11.4 times more likely to develop Addison's disease before or after the diagnosis of CD (24) .…”

Serum sCTLA-4 level is not associated with type 1 diabetes or the coexistence of autoantibodies in children and adolescent patients from the southern region of Saudi Arabia

“…In the current study among few patients sCTLA-4 levels were ranging from 4.7 to 203 pg/mL. The coexistence of CD and autoimmune thyroid diseases with T1DM is well documented, and thyroid and celiac autoimmune disease prevalence can reach up to 10% and 30%, respectively, in patients with T1DM [3,26]. Two thyroid antibodies that are considered indicators of autoimmune thyroiditis are anti-TPO and anti-TG.…”