An unusual antibiotic susceptibility pattern in a Mycobacterium Cosmeticum strain isolated from the chesapeake bay

Atukorale, Vajini; Boire, Nicholas; Dionne, Kim Yi; Riedel, Stefan; Parrish, Nicole

doi:10.4103/2212-5531.201897

Cited by 6 publications

(6 citation statements)

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“…With regard to mycobacteria, Mycobacterium marinum is not the only species of mycobacteria to have been recovered from the CB. A single isolate of Mycobacterium cosmeticum with unusual AR was isolated from the Sandy Point State Park sampling site (Atukorale, Boire, Dionne, Riedel, & Parrish, 2017). This isolate demonstrated resistance to a number of antibiotics including doxycycline, tigecycline, clarithromycin, trimethoprim/sulfamethoxazole, imipenem, cefoxitin, ethionamide, and streptomycin versus isolates of this species described in previously published reports which were pan-susceptible.…”

Section: Discussionmentioning

confidence: 73%

A survey of antimicrobial resistance in Enterobacteriaceae isolated from the Chesapeake Bay and adjacent upper tributaries

et al. 2019

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In recent years, the rise in antimicrobial resistance (AR) in the healthcare setting as well as the environment has been recognized as a growing public health problem. The Chesapeake Bay (CB) and its upper tributaries (UT) is a large and biologically diverse estuary. This pilot study evaluated the presence of AR of gram‐negative bacteria isolated from water samples collected at various sites of the Chesapeake Bay. Bacterial organisms were identified and antimicrobial susceptibility testing was performed by phenotypic and genotypic methods. Ninety‐two distinctly different gram‐negative bacteria were identified; Klebsiella pneumoniae, Enterobacter cloacae, Enterobacter aerogenes, Serratia marcescens, and Escherichia coli were most often isolated. Serratia marcescens was more frequently isolated in samples from the UT compared to the CB. Antimicrobial resistance was more frequently detected in organisms from the CB by phenotypic and genotypic methods. Antimicrobial resistance to ampicillin, imipenem, tetracycline, and chloramphenicol were the most frequently observed resistance patterns. ACT‐1, CMY, and SHV genes were the most frequently detected resistance genes, with predominance in organism isolated from the CB. The results from this study emphasize the importance for further developing comprehensive surveillance programs of AR in bacterial isolates in the various environments, such as recreational and other water systems.

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Section: Discussionmentioning

confidence: 73%

A survey of antimicrobial resistance in Enterobacteriaceae isolated from the Chesapeake Bay and adjacent upper tributaries

et al. 2019

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“…Subsequently, there were more cases of M. cosmeticum infections reported, 8–14 including infections in the lung, joint, catheters, ascites, skin, and colon, as well as systemic infection. M. cosmeticum was also detected in the environment 15–17 . Organ involvement and widespread environmental distribution of M. cosmeticum confirm its pathogenicity.…”

Section: Discussionmentioning

confidence: 74%

“…M. cosmeticum was also detected in the environment. [15][16][17] Organ involvement and widespread environmental distribution of M. cosmeticum confirm its pathogenicity.…”

Section: Discussionmentioning

confidence: 99%

“…In vitro, M. cosmeticum is sensitive to moxifloxacin, clarithromycin, amikacin, sulfamethoxazole, and linezolid. 9 , 15 A patient with ascites infection due to M. cosmeticum successfully recovered after treatments with rifampicin, isoniazid, ethambutol, and pyrazinamide for 2 months and rifampicin and isoniazid for months. 11 Our patient was immunocompromised because of her chronic illnesses and long‐term prednisone treatment.…”

Section: Discussionmentioning

confidence: 99%

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Pneumonia due to Mycobacterium cosmeticum in a patient with systemic sclerosis: A case report

Hu,

Zhang,

Jia

2023

Clinical Case Reports

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“…In addition to Mmuc , the Mmuc -clade includes Mycobacterium phocaicum ( Mpho ), Mycobacterium aubagnense ( Maub ) and Mycobacterium llatzerense ( Mlla ) while Mneo and Mcos belong to the Mneo -clade 7 . These rapid growing NTM are associated with various infections and they show high tolerance against the first-line anti-tuberculosis drugs isoniazid, rifampin and pyrazinamide 3,5,7–12 (and Refs therein) and can also show unusual patterns of antibiotic susceptibility 13 . Together this emphasizes the importance of this group of NTMs and provided an incentive for a comparative genomic analysis focusing on virulence and selected regulatory genes.…”

Section: Introductionmentioning

confidence: 99%

Insight into the biology of Mycobacterium mucogenicum and Mycobacterium neoaurum clade members

Behra

Pettersson

Ramesh

et al. 2019

Sci Rep

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Nontuberculous mycobacteria, NTM, are of growing concern and among these members of the Mycobacterium mucogenicum (Mmuc) and Mycobacterium neoaurum (Mneo) clades can cause infections in humans and they are resistant to first-line anti-tuberculosis drugs. They can be isolated from different ecological niches such as soil, tap water and ground water. Mycobacteria, such as Mmuc and Mneo, are classified as rapid growing mycobacteria, RGM, while the most familiar, Mycobacterium tuberculosis, belongs to the slow growing mycobacteria, SGM. Modern “omics” approaches have provided new insights into our understanding of the biology and evolution of this group of bacteria. Here we present comparative genomics data for seventeen NTM of which sixteen belong to the Mmuc- and Mneo-clades. Focusing on virulence genes, including genes encoding sigma/anti-sigma factors, serine threonine protein kinases (STPK), type VII (ESX genes) secretion systems and mammalian cell entry (Mce) factors we provide insight into their presence as well as phylogenetic relationship in the case of the sigma/anti-sigma factors and STPKs. Our data further suggest that these NTM lack ESX-5 and Mce2 genes, which are known to affect virulence. In this context, Mmuc- and Mneo-clade members lack several of the genes in the glycopeptidolipid (GLP) locus, which have roles in colony morphotype appearance and virulence. For the M. mucogenicum type strain, MmucT, we provide RNASeq data focusing on mRNA levels for sigma factors, STPK, ESX proteins and Mce proteins. These data are discussed and compared to in particular the SGM and fish pathogen Mycobacterium marinum. Finally, we provide insight into as to why members of the Mmuc- and Mneo-clades show resistance to rifampin and isoniazid, and why MmucT forms a rough colony morphotype.

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An unusual antibiotic susceptibility pattern in a Mycobacterium Cosmeticum strain isolated from the chesapeake bay

Abstract: The antimicrobial resistance identified in this M. cosmeticum isolates from the Chesapeake Bay raises some important concerns: (a) why is the susceptibility pattern in this isolate so different from the previously published reports, (b) how did resistance emerge in this isolate,

Cited by 6 publications

References 1 publication

A survey of antimicrobial resistance in Enterobacteriaceae isolated from the Chesapeake Bay and adjacent upper tributaries

A survey of antimicrobial resistance in Enterobacteriaceae isolated from the Chesapeake Bay and adjacent upper tributaries

Pneumonia due to Mycobacterium cosmeticum in a patient with systemic sclerosis: A case report

Insight into the biology of Mycobacterium mucogenicum and Mycobacterium neoaurum clade members

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