An unusual and delayed complication of hyaluronic acid filler injection: a case report

Horriat, Narges L.; Woods, Tina; Medina, Abelardo

doi:10.1080/23320885.2020.1769481

Cited by 3 publications

(3 citation statements)

References 19 publications

(36 reference statements)

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“…To the best of our knowledge, there have been no reported complications occurring at different time points for single filler injections. In cases of delayed complications, infection occurred due to microscopic epidermal abrasions in the skin 8 . However, based on our patient's medical history, there were no such underlying causes.…”

Section: Discussionmentioning

confidence: 69%

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Multiple Delayed Complications at Different Time Points After AQUAfilling Filler Injection for Facial Rejuvenation

Kong

Chung

2021

Journal of Craniofacial Surgery

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Delayed inflammatory and infectious complications occurred in a 63-year-old woman after receiving AQUAfilling filler injection in the forehead and nasolabial folds. The complications were idiopathic and occurred at different time points at different sites. Her condition improved after the removal of the injected materials and capsule, and administration of intravenous antibiotics. Although injection sites differ, inflammation can occur at any site at different time points. The possibility of inflammation at other injection sites should always be considered during periodic follow-up, even if the filler injection site initially shows no signs of complications. Level of Evidence: Level IV

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Section: Discussionmentioning

confidence: 69%

“…In cases of delayed complications, infection occurred due to microscopic epidermal abrasions in the skin. 8 However, based on our patient's medical history, there were no such underlying causes. As AQUAfilling filler is a liquid, hydrophilic material that can absorb body fluids and exudates.…”

Section: Discussionmentioning

confidence: 71%

Multiple Delayed Complications at Different Time Points After AQUAfilling Filler Injection for Facial Rejuvenation

Kong

Chung

2021

Journal of Craniofacial Surgery

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“…We identified six Mycobacterium sp., of which five corresponded to the genus M. fortuitum. Non-tuberculous mycobacterial (NTM) infections have been associated with the infiltration of filler substances by direct inoculation, contiguous or hematogenous dissemination and the use of contaminated substances and are favored by their ability to survive in a variety of environments, such as water and soil, allowing their adherence and resistance [39][40][41][42][43]. Mycobacterium fortuitum, M. chelonae and M. abcessus are listed as the most frequent species causing skin and soft tissue infection [43].…”

Section: Plos Onementioning

confidence: 99%

Infections in patients with adverse reactions to the use of unknown modeling substances for soft tissue enhancement in Cali, Colombia

Moncada

Ríos²,

Castro³

et al. 2023

PLoS ONE

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The infiltration of foreign materials not approved for medical purposes or of modeling substances used in soft tissue to modify the anatomical appearance for aesthetic purposes represents a serious health problem. These procedures lead to the development of delayed complications, including infections. The objective of this study was to characterize infections in patients with adverse reactions to the use of modeling substances in Cali, Colombia. A cross-sectional and descriptive study was used to determine the frequency of bacterial and fungal infections associated with complications from and adverse reactions to the use of modeling substances in 113 patients. We identified microorganisms in 22 patients and a frequency of 68.1% monomicrobial infections and 31.8% polymicrobial infections. The microorganisms identified in our study included Bacillus cereus, Mycobacterium fortuitum, and Pseudomonas stutzeri, among other microorganisms. The presence of adverse effects derived from the use of illegal modeling substances has been demonstrated; among these effects, infections occur with high frequency and place the health of the patient at risk and increase problems in health care.

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Histologic Hitchhikers: A Review of Common Exogenous Artifacts Encountered During Mohs Micrographic Surgery

Lam,

Shamloul,

Samaan

et al. 2024

Dermatol Surg

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BACKGROUND Exogenous artifacts can interfere with accurate histologic tissue evaluation on frozen sections during Mohs micrographic surgery (MMS). Mohs surgeons should be aware of these anomalies to avoid potential misdiagnoses. OBJECTIVE To review exogenous artifacts encountered in frozen tissue pathology during MMS. METHODS A literature search was conducted in PubMed to identify studies reporting on exogenous artifacts encountered during MMS and a list of previously described exogenous artifacts was compiled. A retrospective examination of frozen histology slides from recent Mohs cases at the authors' institution was performed to obtain illustrative examples of these artifacts, supplemented by formalin-fixed paraffin-embedded samples when frozen examples could not be found. RESULTS Exogenous artifacts represent foreign bodies that have been externally introduced into the skin or artifacts resulting from other external factors. If frozen section evaluation is inaccurate, overdiagnosis can occur during MMS, resulting in unnecessary layers, larger margins, and more complex reconstructions. These exogenous tissue changes can mimic inflammatory processes and melanocytic or keratinocyte malignancies on histology. CONCLUSION Exogenous artifacts are common findings during margin assessment in Mohs micrographic surgery. The resulting histological findings can be confusing but correlating them with the clinical and surgical history often reassures surgeons. Recognizing these artifacts facilitates accurate diagnosis and promotes optimal patient care.

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An unusual and delayed complication of hyaluronic acid filler injection: a case report

Cited by 3 publications

References 19 publications

Multiple Delayed Complications at Different Time Points After AQUAfilling Filler Injection for Facial Rejuvenation

Multiple Delayed Complications at Different Time Points After AQUAfilling Filler Injection for Facial Rejuvenation

Infections in patients with adverse reactions to the use of unknown modeling substances for soft tissue enhancement in Cali, Colombia

Histologic Hitchhikers: A Review of Common Exogenous Artifacts Encountered During Mohs Micrographic Surgery

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