An unusual anatomic and geographic location of primary germinoma of the fourth ventricle

Khan, Akbar Ali; Kirkman, Matthew A.; Anderson, Caroline Rachael; Jaunmuktane, Zane; Morris, Robert C.; Kitchen, Neil

doi:10.1016/j.jocn.2012.11.025

Cited by 13 publications

(7 citation statements)

References 5 publications

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“…There is no established management guidelines to medulla oblongata fourth ventricle germinoma. [5912] From the reported cases, as well as our patient, surgery, for both tissue diagnosis and tumor debulking, often constitutes initial management. Postsurgical adjuvant therapy, either radiotherapy or chemotherapy or both, was applied after the tissue diagnosis.…”

Section: Discussionmentioning

confidence: 96%

“…[1358912131415161718] Most of them were from Asian countries, and female was predominant. Imaging with computed tomography (CT) and MRI are important for diagnosis but are often unable to differentiate germinomas from other neoplastic pathologies in the brainstem.…”

Section: Discussionmentioning

confidence: 99%

“…To the best of our knowledge, there are 17 cases of pure primary medulla oblongata germinoma reported in the English literature. [1358912131415161718] We would like to report a case of primary medulla oblongata fourth ventricle germinoma in a young female presented with dyspnea and frequent choking.…”

Section: Introductionmentioning

confidence: 99%

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Dyspnea and choking as presenting symptoms in primary medulla oblongata germinoma

Yip¹,

Tseng²,

Hsu³

et al. 2014

Surg Neurol Int

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Background:The medulla oblongata is the lower half of the brainstem. It contains the cardiac, respiratory, vomiting, and vasomotor centers and deals with autonomic functions such as breathing, heartbeat, and blood pressure. Primary medulla oblongata germinoma is very rare and less than 20 cases have been reported in the English literature.Case Description:A 22-year-old female without any particular past medical history presented to us in October 2012 with the chief complaint of dyspnea and frequent choking for 1 month. Neurological examination revealed lower cranial nerve palsies and nystagmus. Her brain computed tomography (CT) and brain magnetic resonance imaging (MRI) demonstrated a mass lesion at the dorsal surface of medulla oblongata with extension into the inferior fourth ventricle and foramen magnum. She underwent bilateral suboccipital craniotomy and C1 laminoplasty with the grossly total resection of the tumor. The histological examination of the tumor proved germinoma. Postoperative adjuvant radiotherapy was arranged. The latest brain MRI and whole spine MRI done 1 year after surgery showed neither residual nor recurrent tumor in the whole axis. She is regularly followed-up at our outpatient department and is doing well except having left vocal cord palsy, which occurred before surgery.Conclusion:Medulloblastoma, ependymoma, glioma, hemangioblastoma, and cavernous angioma are common intraaxial tumors in the medulla oblongata and fourth ventricle. Intracranial germ cell tumors originate from extragonadal seminal cells and have been found in 0.4-3.4% of patients with primary central nervous system (CNS) tumors in Western countries, while the incidence is reported to be 5-8 times greater in Japan and the Far East. Although germinoma of medulla oblongata is rare and difficult to diagnose preoperatively, it should be included in the differential diagnosis of medulla masses with fourth ventricle extension, especially in Asian population.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

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Dyspnea and choking as presenting symptoms in primary medulla oblongata germinoma

Yip¹,

Tseng²,

Hsu³

et al. 2014

Surg Neurol Int

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“…There have been 24 cases of germinoma of the medulla oblongata and the fourth ventricle reported in the literature ( Table 2 ). Eighteen of these cases were reported from East Asian countries (Japan, n=11; Taiwan, n=3; China, n=3; Thailand, n=1) ( 3 - 7 , 9 - 11 , 13 , 15 - 18 , 20 , 23 ). Sixteen of the 24 cases were women, and 2 cases were men with Klinefelter syndrome (chromosomal karyotype: 47, XXY).…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, in 2013-2017, central nervous system GCTs, cysts, and heterotopias predominantly occurred in women according to the Central Brain Tumor Registry of the United States ( 28 ). Nakajima et al suggested that the female predominance of GCTs in the neurohypophyseal and medulla oblongata regions may be attributed to a later closure of the anterior neuropore in women than in men ( 8 , 10 , 11 , 18 , 29 ).…”

Section: Discussionmentioning

confidence: 99%

Mixed Germ Cell Tumor with a Yolk Sac Tumor Component in the Medulla Oblongata of a 50-year-old Patient: A Case Report and Literature Review

et al. 2023

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Yolk sac tumor (YST) is a rare primary brain tumor that occurs almost exclusively in patients under 30 years old. Intracranial germ cell tumors are most frequently located in the pineal and suprasellar region. Medulla oblongata YSTs are particularly rare. Extragonadal YSTs may be difficult to diagnose because of their characteristics, such as the rarity and variety of growth patterns. Furthermore, they are known to have a very poor prognosis. We herein report a case of YST of the medulla oblongata in a 50-year-old woman. She was followed up for 18 months without any tumor recurrence.

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Germinoma

2016

Diagnostic Imaging: Brain

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An unusual anatomic and geographic location of primary germinoma of the fourth ventricle

Cited by 13 publications

References 5 publications

Dyspnea and choking as presenting symptoms in primary medulla oblongata germinoma

Dyspnea and choking as presenting symptoms in primary medulla oblongata germinoma

Mixed Germ Cell Tumor with a Yolk Sac Tumor Component in the Medulla Oblongata of a 50-year-old Patient: A Case Report and Literature Review

Germinoma

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