An unlikely role for the NAT2 genotypes and haplotypes in the oral cancer of south Indians

Balaji, Lakshmi; Krishna, Balaji Singh; Lakkakula, Bhaskar Vks

doi:10.1016/j.archoralbio.2011.10.019

Cited by 5 publications

(3 citation statements)

References 31 publications

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“…Fourteen articles [ 22 , 23 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 ] reported the results in Caucasians, nine [ 35 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ] in Asians, and five [ 56 , 57 , 58 , 59 , 60 ] among participants of mixed ethnicity. The control source in eighteen articles [ 22 , 23 , 35 , 37 , 39 , 40 , 43 , 44 , 45 , 46 , 48 , 49 , 51 , 52 , 53 , 57 , 58 , 60 ] was hospitals and ten [ 36 , 38 , 41 , 42 , 47 , 50 , ...…”

Section: Resultsmentioning

confidence: 99%

“…Table 2 shows the prevalence of slow and rapid acetylators of NAT1 and NAT2 polymorphisms. Eight studies [ 23 , 35 , 38 , 39 , 44 , 47 , 52 , 60 ] included NAT1 polymorphism with 1509 HNC cases and 1829 controls and twenty-five studies [ 22 , 23 , 35 , 36 , 37 , 38 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 53 , 54 , 55 , 56 , 57 , 58 , 59 ] included NAT2 polymorphism with 4393 HNC cases and 5321 controls.…”

Section: Resultsmentioning

confidence: 99%

“…Comparing the individual studies included in the meta-analysis, differences were observed between the studies. For example, five studies [ 41 , 46 , 48 , 55 ] found an elevated risk of HNC for NAT2 slow acetylators, one found a protective role of these acetylators in HNC patients, and three did not find any association between NAT2 polymorphism and the HNC risk [ 23 , 45 , 49 ].…”

Section: Discussionmentioning

confidence: 99%

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Association of N-acetyltransferases 1 and 2 Polymorphisms with Susceptibility to Head and Neck Cancers—A Meta-Analysis, Meta-Regression, and Trial Sequential Analysis

Mohammadi

Roochi²,

Sadeghi³

et al. 2021

Medicina

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Background and objective: N-acetyltransferases 1 and 2 (NAT1 and NAT2) genes have polymorphisms in accordance with slow and rapid acetylator phenotypes with a role in the development of head and neck cancers (HNCs). Herein, we aimed to evaluate the association of NAT1 and NAT2 polymorphisms with susceptibility to HNCs in an updated meta-analysis. Materials and methods: A search was comprehensively performed in four databases (Web of Science, Scopus, PubMed/Medline, and Cochrane Library until 8 July 2021). The effect sizes, odds ratio (OR) along with 95% confidence interval (CI) were computed. Trial sequential analysis (TSA), publication bias and sensitivity analysis were conducted. Results: Twenty-eight articles including eight studies reporting NAT1 polymorphism and twenty-five studies reporting NAT2 polymorphism were involved in the meta-analysis. The results showed that individuals with slow acetylators of NAT2 polymorphism are at higher risk for HNC OR: 1.22 (95% CI: 1.02, 1.46; p = 0.03). On subgroup analysis, ethnicity, control source, and genotyping methods were found to be significant factors in the association of NAT2 polymorphism with the HNC risk. TSA identified that the amount of information was not large enough and that more studies are needed to establish associations. Conclusions: Slow acetylators in NAT2 polymorphism were related to a high risk of HNC. However, there was no relationship between NAT1 polymorphism and the risk of HNC.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Association of N-acetyltransferases 1 and 2 Polymorphisms with Susceptibility to Head and Neck Cancers—A Meta-Analysis, Meta-Regression, and Trial Sequential Analysis

Mohammadi

Roochi²,

Sadeghi³

et al. 2021

Medicina

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NAT2 polymorphisms with oral carcinoma susceptibility: a meta-analysis

et al. 2012

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Published data have implicated NAT2 polymorphisms as risk factors for various cancers. A number of studies have focused on the association of NAT2 polymorphisms with susceptibility to oral carcinoma and have yielded inconclusive results. The aim of the present study was to derive a more precise estimation of the relationship. We first carried out a deliberate search in the databases without a language limitation, covering all papers published up to Dec 2011. A total of seven case-control studies including 1,379 cases and 1,868 controls were selected and the relevant data were extracted for systematic meta-analyses. No significant association was found for the overall data (OR: 1.04, 95 % CI: 0.79-1.39). In subgroup analyses according to ethnicity, slow acetylators might increase oral cancer risk among Asians (OR: 1.38, 95 % CI: 1.04-1.82) but not Caucasians or Mixed races. The data suggested that NAT2 polymorphisms might be a low-penetrant risk factor for oral carcinoma in Asians.

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N-acetyltransferase 2 genetic variants confer the susceptibility to head and neck carcinoma: evidence from 23 case–control studies

et al. 2013

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Previous evidence indicated that N-acetyltransferase 2 (NAT2) polymorphisms might be a risk factor for several cancers. A number of studies have been conducted on the association between NAT2 polymorphisms and head and neck cancer (HNC) risk. Nevertheless, the results were conflicting. Published meta-analysis on this issue has generated inconclusive results. Thus, we aimed to derive a more precise estimation of the relationship by conducting an updated meta-analysis. Published data prior to August 2013 have been searched and screened. Subgroup analysis on ethnicity, source of controls, sample size, and genotyping method were also performed. As a result, a total of 23 case-control studies including 4,028 cases and 4,872 controls were selected for analysis. Interestingly, the results showed that NAT2 polymorphisms might increase HNC risk for the overall data (OR 1.23, 95% CI 1.01-1.49). Moreover, in subgroup analyses according to ethnicity, data showed that slow acetylators might increase HNC susceptibility among Asians (OR 1.78, 95% CI 1.27-2.49), but not among Caucasians or mixed ethnicities. In conclusion, NAT2 polymorphism might be a low-penetrant risk factor for HNC among Asians.

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An unlikely role for the NAT2 genotypes and haplotypes in the oral cancer of south Indians

Cited by 5 publications

References 31 publications

Association of N-acetyltransferases 1 and 2 Polymorphisms with Susceptibility to Head and Neck Cancers—A Meta-Analysis, Meta-Regression, and Trial Sequential Analysis

Association of N-acetyltransferases 1 and 2 Polymorphisms with Susceptibility to Head and Neck Cancers—A Meta-Analysis, Meta-Regression, and Trial Sequential Analysis

NAT2 polymorphisms with oral carcinoma susceptibility: a meta-analysis

N-acetyltransferase 2 genetic variants confer the susceptibility to head and neck carcinoma: evidence from 23 case–control studies

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