“…The precipitation of paraproteins with reagents increase the sample turbidity and lead to interference in nephelometric, turbidimetric or colorimetric analysis. Paraproteins also may interfere immunoassays by interaction with the specific antibody reagents [10]. Another mechanism is that paraproteins inhibit of three stages of fibrin formation: the proteolytic action of thrombin on fibrinogen, the aggregation of fibrin monomers, and the stabilization of fibrin by cross-linkages in the γ and α chain.…”