An unique encounter with paraprotenemia

Abstract

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Atypic separator gel flotation in blood collection tube in a patient with hyperproteinemia

“…The precipitation of paraproteins with reagents increase the sample turbidity and lead to interference in nephelometric, turbidimetric or colorimetric analysis. Paraproteins also may interfere immunoassays by interaction with the specific antibody reagents [10]. Another mechanism is that paraproteins inhibit of three stages of fibrin formation: the proteolytic action of thrombin on fibrinogen, the aggregation of fibrin monomers, and the stabilization of fibrin by cross-linkages in the γ and α chain.…”

“…Another mechanism is that paraproteins inhibit of three stages of fibrin formation: the proteolytic action of thrombin on fibrinogen, the aggregation of fibrin monomers, and the stabilization of fibrin by cross-linkages in the γ and α chain. Residual fibrin masses may cause bulky gelatinous clot formation and make it difficult to separate the serum after centrifugation [10]. Thus, obtaining sufficient serum for biochemical analyses becomes difficult.…”