Abstract:Tetrasubstituted alkene derivatives are synthetically important compounds and one of the important research areas in organic chemistry. Stereoselective synthesis of all-carbon tetrasubstituted alkenes is a challenging problem in chemical synthesis because of the uncontrolled Z/E stereoselectivity. Here we described an unexpended stereocontrolled rearrangement for the synthesis of tetrasubstituted alkenes, each group different from the other. The reaction of ethyl 4-hydroxy-4-(substituted phenyl)-2-butynoate de… Show more
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