An Unexpected Cause of Pulmonary Cannonball Lesion

Pinato, David J.; Tan, Wee Yong; Gately, Amy

doi:10.1097/jto.0b013e3182a85298

Cited by 3 publications

(1 citation statement)

References 3 publications

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“…Table 1 outlines the published cases of pulmonary EMH, the respective interventions utilized and the corresponding treatment outcomes. 4 , 5 , 8-10 , 14-20 …”

Section: Discussionmentioning

confidence: 99%

Pulmonary Extramedullary Hematopoiesis Involving the Pulmonary Artery

Monga

Silverman

2015

Hematology Reports

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Extramedullary hematopoiesis (EMH) occurs as a complication of hematologic disorders such as myelofibrosis, sickle cell anemia and thalassemia. The extramedullary tissue usually involves liver, spleen and lymph nodes, less frequently the chest. We present a recent case of a man with myeloproliferative neoplasm who developed pulmonary hemorrhage secondary to EMH in the lung and pulmonary artery. Radiation therapy was considered the best approach, but it didn’t work and the patient died a week after radiation therapy was completed. We also review herein the present literature.

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“…Table 1 outlines the published cases of pulmonary EMH, the respective interventions utilized and the corresponding treatment outcomes. 4 , 5 , 8-10 , 14-20 …”

Section: Discussionmentioning

confidence: 99%

Pulmonary Extramedullary Hematopoiesis Involving the Pulmonary Artery

Monga

Silverman

2015

Hematology Reports

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Exploring extramedullary hematopoiesis: unraveling the hematopoietic microenvironments

Rivera-Torruco,

Muench,

Valle-Rios

2024

Front. Hematol.

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Hematopoiesis is a process by which all blood cells are formed. The mechanisms controlling it have been studied for decades. Surprisingly, while hematopoietic stem cells are among the most extensively studied stem cell types, the complete understanding of how they are regulated during development, adulthood, or in non-homeostatic conditions remains elusive. In this review, our primary focus is on research findings that explore where hematopoietic precursors are found in adults outside their primary niches in the bone marrow. This phenomenon is termed extramedullary hematopoiesis (EMH). Early in development hematopoietic stem cells migrate through different regions within and outside the embryo and later the fetus. Although, the primary home for hematopoietic progenitors is the adult bone marrow, it is now recognized that other adult organs may act as hematopoietic progenitor reservoirs both in mice and humans. The first reports about this topic were principally originated from clinical observations, in cases where the bone marrow was malfunctioning, leading to an aberrant hematopoiesis outside the bone marrow. It is worth highlighting that those extramedullary organs, like the small intestine or fat tissue, contain subsets of fully functioning hematopoietic progenitors demonstrated by both in vitro and in vivo studies. Nonetheless, there are still some unanswered questions regarding the source of these cells, how they differ in function compared to their counterparts in the bone marrow, and the specific roles they play within the tissues where they are located.

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Extramedullary Hematopoiesis in Myelodysplastic Syndromes: A Systematic Literature Review

Wang

Shi

2022

Hemato

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Extramedullary hematopoiesis is rarely seen in patients with myelodysplastic syndromes, and its clinical characterizations are not well-defined. Here, we systematically reviewed the published literature to summarize the clinical manifestations, treatments, and long-term outcomes of biopsy-proven extramedullary hematopoiesis in patients with myelodysplastic syndromes. We included 41 patients, and ring sideroblasts were the most common myelodysplastic subtype (30.6%). Extramedullary hematopoiesis was typically symptomatic on presentation due to local compression, frequently involving the liver or spleen (36.6%), or the paravertebral region (24.4%). Notably, ring sideroblasts were predominantly seen in patients with non-hepatosplenic involvement (38.5 vs. 6.7%, p = 0.034). Interventions, when required, usually included surgery (36.8%) or radiation (13.2%), which led to symptomatic improvement in 55.5% of patients. The median overall survival of the current cohort was 7 months. The current study confirms the rarity of extramedullary hematopoiesis as a complication of myelodysplastic syndromes; however, its outcomes in response to systemic modern therapies require further investigation.

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An Unexpected Cause of Pulmonary Cannonball Lesion

Cited by 3 publications

References 3 publications

Pulmonary Extramedullary Hematopoiesis Involving the Pulmonary Artery

Pulmonary Extramedullary Hematopoiesis Involving the Pulmonary Artery

Exploring extramedullary hematopoiesis: unraveling the hematopoietic microenvironments

Extramedullary Hematopoiesis in Myelodysplastic Syndromes: A Systematic Literature Review

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