An Uncommon Intramedullary Tumor: Primary Spinal Cord Melanoma

Çetinalp, Nuri Eralp; Yıldırım, Ali Erdem; Divanlıoğlu, Denizhan; Belen, Deniz

doi:10.4184/asj.2014.8.4.512

Cited by 19 publications

(13 citation statements)

References 9 publications

(12 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It can arise from within or outside the spinal cord. Primary leptomeningeal, nerve root, extradural, and intradural (including extramedullary and intramedullary) lesions have been reported [4][5][6][7][8][9][10][11].…”

Section: Discussionmentioning

confidence: 99%

Primary Spinal Melanoma With Intra- and Extradural Extensions: A Rare Case

Saleem¹,

Saleem²,

Asghar³

et al. 2021

Cureus

View full text Add to dashboard Cite

Primary spinal melanoma (PSM) is a rare primary central nervous system melanoma with limited literature. A 30-year-old male presented with one year of progressive bilateral leg weakness and back pain. Physical examination revealed slightly decreased power and deep tendon reflexes of the lower extremities, decreased sensation at the level of T10, and normal anal sphincter and plantar reflexes. Magnetic resonance imaging (MRI) scan of the thoracolumbar spine revealed a hypointense lesion on T2-weighted and a hyperintense lesion on T1-weighted imaging at the level of T10 with mild extensions. The lesion was causing a mass effect on the spinal cord. The patient underwent laminectomy and near-total excision which showed a black, firm-to-hard, scarcely vascular extradural tumor extending from T10 to T11 that adhered to nerve roots. Histopathological examination and immunostaining with S-100 and Melan-A stains confirmed the diagnosis of malignant melanoma. Other imaging studies like brain computed tomography (CT) and positron emission tomography/computed tomography (PET/CT) scans, and chest X-ray were normal. On follow-up, the patient reported improvement in the power of his lower limbs with intact sensory function and sphincters. The first radiotherapy session was scheduled for six weeks postoperatively. There was no recurrence at a two-year follow-up. The possibility of a melanocytic tumor should be considered for a spinal lesion with paramagnetic properties as early surgical intervention is important for diagnosis and improved survival.

show abstract

Section: Discussionmentioning

confidence: 99%

Primary Spinal Melanoma With Intra- and Extradural Extensions: A Rare Case

Saleem¹,

Saleem²,

Asghar³

et al. 2021

Cureus

View full text Add to dashboard Cite

show abstract

“…Enhancement patterns may also be inhomogeneous, peripheral, or nodular. 7 , 15 , 16 Lesions secondary to leptomeningeal dissemination also display hyperintense signals on T1-weighted imaging, with gadolinium enhancement and hypointense signals on T2-weighted imaging. 7,12 Similarly, in the present case, the primary lesion and leptomeningeal spread presented with a hyperintense signal on T1-weighted images and a hypointense signal on T2-weighted images owing to intratumoral pigment.…”

Section: Discussionmentioning

confidence: 99%

Primary intramedullary malignant melanoma: can imaging lead to the correct diagnosis?

2020

View full text Add to dashboard Cite

Melanoma is a malignant neoplasm of melanin-producing cells. Melanoma usually occurs in the skin, but can also arise in any anatomical site that contains melanocytes, such as mucous membranes, the eyes, and the central nervous system (CNS). Primary CNS malignant melanoma most often develops in the leptomeninges. We report a case of a rare intramedullary melanoma of the thoracic spinal cord. A 78-year-old man was treated with surgery, radiotherapy, and immunotherapy for leptomeningeal spread. We also discuss the role of imaging methods in diagnosis and follow-up. Medullary melanoma occurs more frequently in adults. The most common presenting symptoms are the insidious onset of lower extremity weakness and paresthesia. Magnetic resonance imaging is the method of choice for evaluation. Although there are no imaging features to accurately distinguish primary malignant melanoma from other melanocytic or hemorrhagic tumors, hyperintensity on T1-weighted magnetic resonance imaging should lead to inclusion of this neoplasm in differential diagnosis of spinal cord tumors. Positron emission tomography-computed tomography is a useful auxiliary examination to evaluate the extent of local and metastatic disease. Surgical resection is the primary treatment for intramedullary melanoma. However, the efficacy of adjunctive radiotherapy and chemotherapy for primary spinal cord malignant melanoma is still controversial.

show abstract

“…5 While other authors, Farrokh et al and Cetinalp et al reported that malignant melanoma of intra-medullary origin was more common in the thoracic region. 1 8 Most of the patients were of middle-age group without any gender preference. The majority of tumors were solitary, and only a few cases were reported with multiple foci.…”

Section: Discussionmentioning

confidence: 99%

“…It has been observed that the imaging spectrum of these melanomas overlaps with other pigmented tumors such as melanocytic schwannoma and melanocyto-ma. 4 8 The melanoma has different radiological characteristic signals (hyperintensity on T1-weighted [W] and hypointensity on T2-W) on MRI examination than other similar tumors, such as schwannoma or meningioma. 13 On contrast MRI, these tumors showed a homogeneous enhancement of the lesion.…”

Section: Discussionmentioning

confidence: 99%

Primary Spinal Cord Melanoma of Intradural Extramedullary Origin

Sharma

Sinha

2019

Journal of Neurosciences in Rural Practice

View full text Add to dashboard Cite

Primary malignant melanoma is the very rare entity of the central nervous system. It accounts only 1% of all melanoma cases. A 67-year-old patient presented to us with lower back pain radiating to the left lower limb and progressive weakness of both lower limbs. She underwent magnetic resonance imaging scan of lumbosacral region that suggested T1 hyperintense, T2 hypointense, extramedullary altered signal intensity lesion at L1 and L2 vertebral level compressing terminal spinal cord, and cauda equine region. On histopathological examination, findings were suggestive of malignant melanoma that was confirmed with immunohistochemistry examination (positive for S-100, Melan-A, and HMB-45). Here, we are discussing an unusual case of primary malignant melanoma of conus and cauda equine region with comprehensive review regarding management and prognosis of the tumor.

show abstract

An Uncommon Intramedullary Tumor: Primary Spinal Cord Melanoma

Cited by 19 publications

References 9 publications

Primary Spinal Melanoma With Intra- and Extradural Extensions: A Rare Case

Primary Spinal Melanoma With Intra- and Extradural Extensions: A Rare Case

Primary intramedullary malignant melanoma: can imaging lead to the correct diagnosis?

Primary Spinal Cord Melanoma of Intradural Extramedullary Origin

Contact Info

Product

Resources

About