An Uncommon Great Pretender in Oral Cavity Lesions: The Masson’s Tumor

Immunohistochemical Study of Differential Expressions of CD31, ERG, VEGF-A, α-SMA, Glut-1, CD105, D2-40 and Ki-67 in Oral Intravascular Papillary Endothelial Hyperplasia

“…In this study, there were more males than females but the age range was similar to that reported previously; lesion sizes were also similar to previous reports, except for one case involving the buccal mucosa region to the infratempo-ral fossa, and the pterygopalatine fossa; and the surface property was also similar to previous reports. IPEH is rarely diagnosed clinically [5][6][7][8] , and in this study, the preoperative clinical diagnosis of most of the cases was hemangioma. Therefore, it is important to perform histopathological diagnosis and not to overlook the pathological features of IPEH.…”

“…In 1976, Clarkin and Enzinger 3) named this lesion "intravascular papillary endothelial hyperplasia", and this name has been used ever since. IPEH has the propensity to develop in the fingers, soles of the feet, and head and neck, while it is reported to be relatively rare in the oral cavity [4][5][6][7][8][9][10][12][13][14][15][16][17][18][19][20][21][22][23][24][25] . Lesions in the oral cavity are frequently reported in the lower lip, tongue, buccal mucosa, upper lip, and gingiva 5,26,27) .…”

“…Intravascular papillary endothelial hyperplasia (IPEH) is a lesion formed by proliferation of vascular endothelial cells in the form of papillary structures toward the vascular lumen [1][2][3][4] . The lesions occur commonly in the fingers, soles of the feet, and head and neck 4) , while occurrence in the oral and maxillofacial region is relatively rare 5,6) . In addition, reports of IPEH have demonstrated that proliferation of vascular endothelial cells is confined to within the blood vessel and is associated with the organization of thrombi [2][3][4][7][8][9][10] .…”