An uncommon cause of small bowel obstruction: isolated primary granulocytic sarcoma

Kumar, Bhumesh; Bommana, V.; Irani, Farzan; Kasmani, Rahil; Mian, Amir; Mahajan, Kalyani

doi:10.1093/qjmed/hcp051

Cited by 13 publications

(22 citation statements)

References 4 publications

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“…On light microscopy, diffuse, infiltrating medium to large cells, with occasional prominent nucleoli and minimal-to-moderate eosinophilic cytoplasm are noted. The presence of mixed maturing eosinophils supports the diagnosis of GS [8,9]. Based on the degree of myeloid maturation, the tumors can be classified into blastic, immature, and welldifferentiated types.…”

Section: Discussionmentioning

confidence: 70%

“…More than 50 % of these tumors are misdiagnosed as malignant lymphoproliferative disorders [1,8]. Little or no myeloid differentiation often leads to misdiagnosis as a non-Hodgkin's lymphoma [8,9].…”

Section: Discussionmentioning

confidence: 99%

“…The breast involvement is rare [9]. Primary GS of the breast usually presents as a painless breast lump which is noted on self-breast exam or mammography.…”

Section: Discussionmentioning

confidence: 99%

“…The lesions may be isolated or multiple, and involve one or both breasts. Almost all of the reported cases occurred in women [9]. Diagnosis of primary GS of the breast can be challenging.…”

Section: Discussionmentioning

confidence: 99%

“…Diagnosis of primary GS of the breast can be challenging. It can be misdiagnosed as a primary breast malignancy, particularly, invasive lobular carcinoma, medullary carcinoma, lymphoma, sarcoma, or melanoma [9]. Correct diagnosis requires a correlation between immunopathologic, cytogenetic, and molecular studies.…”

Section: Discussionmentioning

confidence: 99%

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Allogeneic Hematopoietic Stem Cell Transplantation as Treatment for Primary Granulocytic Sarcoma of the Breast

Xue

et al. 2015

Cell Biochem Biophys

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Primary granulocytic sarcoma (GS) is an uncommon, extramedullary proliferation of myeloid cells, occurring in the absence of antecedent myeloproliferative disorder. Breast involvement is uncommon. A diagnosis of GS portends a poor prognosis. Even with intensive chemotherapy for AML, progression to overt leukemia can be delayed for 2-3 years. We, report a 29-year-old man who presented with a painless, left breast lump. A modified radical mastectomy followed by histopathological and immunohistochemical testing confirmed a granulocytic sarcoma. There was no evidence of a concurrent leukemia. Intensive chemotherapy for acute myelogenous leukemia was instituted. Allogenic hematopoietic stem cell transplantation was successfully given. The patient remains in complete remission at follow-up. We highlight the importance of timely diagnosis of this uncommon entity with institution of intensive therapy. Early use of allogenic bone marrow transplantation in the treatment of primary GS may be warranted.

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Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 99%

“…The breast involvement is rare [9]. Primary GS of the breast usually presents as a painless breast lump which is noted on self-breast exam or mammography.…”

Section: Discussionmentioning

confidence: 99%

“…The lesions may be isolated or multiple, and involve one or both breasts. Almost all of the reported cases occurred in women [9]. Diagnosis of primary GS of the breast can be challenging.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations