An Umbrella Review Exploring the Effect of Periodontal Treatment in Pregnant Women on the Frequency of Adverse Obstetric Outcomes

Rangel-Rincón, Leidy Johana; Vivares-Builes, Annie Marcela; Botero, Javier Enrique; Agudelo‐Suárez, Andrés A.

doi:10.1016/j.jebdp.2017.10.011

Cited by 18 publications

(21 citation statements)

References 76 publications

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“…The authors identified 17 systematic reviews with or without metaanalyses from 2006 to 2020 of randomized controlled trials on the effect of treating periodontal disease on perinatal outcomes, including two umbrella reviews of systematic reviews. 1,[74][75][76][77][78][79][80][81][82][83][84][85][86][87][88][89] Eight of these systematic reviews/meta-analyses failed to support a causal relationship between periodontal disease and any of the study's adverse pregnancy outcomes of interest, while nine showed a statistically significant improvement following nonsurgical periodontal treatment in at least one of the pregnancy outcomes of interest or in a subgroup analysis. One of the studies, a 2017 Cochrane review 1 of 15 randomized controlled trials investigating the effects of periodontal treatment in preventing or reducing perinatal morbidity and mortality, concluded that the evidence was unclear on the effect of periodontal treatment on preterm birth, perinatal mortality, and preeclampsia.…”

Section: Adverse Pregnancy Outcomes and Their Association With Periodontal Diseasementioning

confidence: 99%

Periodontology and pregnancy: An overview of biomedical and epidemiological evidence

Raju

Berens

2021

Periodontology 2000

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Women are particularly susceptible to developing gingival problems during pregnancy. In addition, periodontal disease in pregnant women may lead to adverse outcomes for both mother and infant, which have serious clinical and public health implications. Both scenarios have been extensively researched, helping to bring attention to pregnant women as an important and vulnerable population as it concerns periodontal health. The increase in gingival inflammation caused by hormonal changes in pregnant women is undisputed and has been studied and documented since the 1960s, although the exact etiology is not fully understood. The relationship between periodontal disease during pregnancy and adverse pregnancy outcomes is less substantiated, because of conflicting evidence. This review of the biomedical and epidemiologic literature provides an overview of both sides of this relationship and examines the potential mechanisms for developing periodontal disease during pregnancy and the proposed mechanisms by which periodontal disease leads to adverse pregnancy outcomes.

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Section: Adverse Pregnancy Outcomes and Their Association With Periodontal Diseasementioning

confidence: 99%

Periodontology and pregnancy: An overview of biomedical and epidemiological evidence

Raju

Berens

2021

Periodontology 2000

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“…The issue of clinical trials with small sample sizes was also highlighted in previous reviews that summarize the evidence of published systematic reviews and meta-analyses of RCTs in the perinatal epidemiology field. 19–22…”

Section: Methodological and Design Issuesmentioning

confidence: 99%

Perinatal epidemiology: Issues, challenges, and potential solutions

Giannakou

2020

Obstet Med

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Perinatal epidemiology research is concerned with identifying the effects of events during pregnancy on pregnancy outcomes that include maternal, fetal, and neonatal health outcomes. Randomized trials in perinatal research face many challenges, including randomization difficulties, ethical considerations, and inadequate statistical power due to the small number of subjects eligible for participation. For these reasons, most epidemiological studies conducted in this research field are observational and include different types of bias. This review describes the key methodological difficulties in the design and analysis of randomized and observational studies in perinatal epidemiology, and provides potential corrective approaches.

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“…Authors were contacted to obtain missing information. After scoring, each review was classified into high, medium and low quality if it obtained a score between 8 and 11, 4 and 7 and 0 and 3, respectively (Rangel‐Rincón et al ). The agreement between the two reviewers (VN and SP) and the intra‐examiner agreement in appraising the quality of included reviews was calculated by Cohen’s kappa analysis.…”

Section: Methodsmentioning

confidence: 99%

Association between diabetes and the outcome of root canal treatment in adults: an umbrella review

et al. 2019

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Background Diabetes mellitus is the most common metabolic disorder amongst dental patients. The association between the diabetes and the outcome of root canal treatment is unclear. Aim To conduct an umbrella review to determine whether there is an association between diabetes and the outcome of root canal treatment. Data source The protocol of the review was developed and registered in the PROSPERO database (CRD42019141684). Four electronic databases (PubMed, EBSCHOhost, Cochrane and Scopus databases) were used to perform a literature search until July 2019. Study eligibility criteria, participants and interventions Systematic reviews with or without meta‐analyses published in English assessing any outcomes of root canal treatment comparing diabetic and nondiabetic patients were included. Two reviewers were involved independently in study selection, data extraction and appraising the reviews that were included. Disagreements were resolved with the help of a third reviewer. Study appraisal and synthesis methods The quality of the reviews was assessed using the AMSTAR tool (A measurement tool to assess systematic reviews), with 11 items. Each AMSTAR item was given a score of 1 if the criterion was met, or 0 if the criterion was not met or the information was unclear. Results Four systematic reviews were included. The AMSTAR score for the reviews ranged from 5 to 7, out of a maximum score of 11, and all the systematic reviews were classified as ‘medium’ quality. Limitations Only two systematic reviews included a meta‐analysis. Only systematic reviews published in English were included. Conclusions and implications of key findings Diabetes mellitus is associated with the outcome of root canal treatment and can be considered as a preoperative prognostic factor.

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An Umbrella Review Exploring the Effect of Periodontal Treatment in Pregnant Women on the Frequency of Adverse Obstetric Outcomes

Cited by 18 publications

References 76 publications

Periodontology and pregnancy: An overview of biomedical and epidemiological evidence

Periodontology and pregnancy: An overview of biomedical and epidemiological evidence

Perinatal epidemiology: Issues, challenges, and potential solutions

Association between diabetes and the outcome of root canal treatment in adults: an umbrella review

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