An Ultrasonic Phased Array Applicator for Hyperthermia

Ocheltree, K.B.; Benkeser, P.J.; Frizzell, Leon A.; Cain, Charles A.

doi:10.1109/t-su.1984.31537

Cited by 46 publications

(9 citation statements)

References 2 publications

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“…However, it was soon realized that the treatment of many or large tumors would require greater spatial coverage than that provided by fixed-focus, single-element transducers. As a result, ultrasound transducer arrays comprising multiple elements were investigated for therapy [19, 20, 21, 22], though these early devices provided limited electronic control over the focal spots’ shape and location. Phased arrays also allow wave-front distortions induced by acoustic propagation through heterogeneous tissues to be accounted for, which is not possible with single-element transducers and was critical for enabling the use of FUS therapy in the brain [23].…”

Section: Introductionmentioning

confidence: 99%

Image-guided ultrasound phased arrays are a disruptive technology for non-invasive therapy

Hynynen¹,

Jones²

2016

Phys. Med. Biol.

105

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Focused ultrasound offers a non-invasive way of depositing acoustic energy deep into the body, which can be harnessed for a broad spectrum of therapeutic purposes, including tissue ablation, the targeting of therapeutic agents, and stem cell delivery. Phased array transducers enable electronic control over the beam geometry and direction, and can be tailored to provide optimal energy deposition patterns for a given therapeutic application. Their use in combination with modern medical imaging for therapy guidance allows precise targeting, online monitoring, and post-treatment evaluation of the ultrasound-mediated bioeffects. In the past there have been some technical obstacles hindering the construction of large aperture, high-power, densely-populated phased arrays and, as a result, they have not been fully exploited for therapy delivery to date. However, recent research has made the construction of such arrays feasible, and it is expected that their continued development will both greatly improve the safety and efficacy of existing ultrasound therapies as well as enable treatments that are not currently possible with existing technology. This review will summarize the basic principles, current statures, and future potential of image-guided ultrasound phased arrays for therapy.

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Section: Introductionmentioning

confidence: 99%

Image-guided ultrasound phased arrays are a disruptive technology for non-invasive therapy

Hynynen¹,

Jones²

2016

Phys. Med. Biol.

105

View full text Add to dashboard Cite

show abstract

“…In 1984, Cain et al followed by describing methods that could allow electronic beam steering with an array driven with a reduced number of independent radiofrequency (RF) lines for producing mild hyperthermia (Ocheltree et al, 1984). In 1984, Cain et al followed by describing methods that could allow electronic beam steering with an array driven with a reduced number of independent radiofrequency (RF) lines for producing mild hyperthermia (Ocheltree et al, 1984).…”

Section: External Devicesmentioning

confidence: 99%

High-intensity focused ultrasound for medical therapy

Ellens

Hynynen

2015

Power Ultrasonics

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“…The approach made use of the development of highpower phased ultrasound arrays [30][31][32][33][34][35][36][37][38] and driving systems suitable for thermal ablation [39]. It was demonstrated that a phase conjugation approach with a small transmitter inside the brain could be used to focus through a skull fragment [40].…”

Section: Development Of Transskull Ultrasound Surgerymentioning

confidence: 99%