An ultrasonic osteotomy device enhanced post-osteotomy bone healing beyond that with a conventional rotary device in a rat calvarial model

Abstract

Ultrasonic osteotomy devices (UODs) have many clinical bene ts; for example, they cause little damage to adjacent tissues in oral surgery. However, few reports have focused on bone healing with UODs. This study aimed to compare bone healing after osteotomy with UODs versus rotary osteotomy devices (RODs) in a rat calvarial defect model. Calvarial bone defects were made with a UOD on the right side and an ROD on the left side. Micro-CT analysis revealed that the bone volume was greater with a UOD than with an ROD at 2-3 weeks. In HE-stained sections and micro-CT images, the bone wound gap was closed earlier on the UOD side than on the ROD side. Bone thickness, the quantity of newly formed bone, and the number of osteocytes were greater on the UOD side than on the ROD side. Scanning electron microscopy (SEM) showed that UOD cuts had smoother surfaces than ROD cuts. Osteoblast-like cells harvested from bone chips cut by the UOD had greater proliferative activity than those harvested from ROD-cut bone chips. The use of a UOD may assist bone regeneration, presumably because of osteoblast activation by ultrasonic microvibration and UODs cause less damage to the bone than RODs.

Design and optimization of a half-wavelength ultrasonic bone scalpel

“…It uses high-frequency mechanical vibration and cavitation effect to cut bone materials [5][6][7]. The UBS has the advantages of accurate cutting, tissue selectivity and less bleeding [8][9][10], so the UBS is of great significance for orthopedic surgery.…”