An ultrasensitive method of real time pH monitoring with complementary metal oxide semiconductor image sensor

Devadhasan, Jasmine Pramila; Kim, Sang-Hyo

doi:10.1016/j.aca.2014.12.015

Cited by 33 publications

(21 citation statements)

References 36 publications

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“…These are further discussed in the Challenges and future needs section. [27][28][29] Comparison of these four optical sensing modalities is graphically illustrated in Fig. 2.…”

Section: Recent Optical Smartphone Sensorsmentioning

confidence: 99%

Recent approaches for optical smartphone sensing in resource-limited settings: a brief review

2016

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“…These are further discussed in the Challenges and future needs section. [27][28][29] Comparison of these four optical sensing modalities is graphically illustrated in Fig. 2.…”

Section: Recent Optical Smartphone Sensorsmentioning

confidence: 99%

Recent approaches for optical smartphone sensing in resource-limited settings: a brief review

2016

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“…Fluorescence in situ hybridization (FISH) is a method that uses specific DNA sequences tagged with fluorophores to detect chromosome or gene status in the nucleus [48]. Conventional FISH technique is time consuming, labor intensive, and expensive [49]. It usually takes 2 or 3 days to complete analysis and reagent required for assay is expensive such as fluorescently labeled DNA probes.…”

Section: Label‐dependent Technologiesmentioning

confidence: 99%

Microfluidic applications on circulating tumor cell isolation and biomimicking of cancer metastasis

Jiang

Wang

et al. 2020

Electrophoresis

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Microfluidic applications on circulating tumor cell isolation and biomimicking of cancer metastasisThe prognosis of malignant tumors is challenged by insufficient means to effectively detect tumors at early stage. Liquid biopsy using circulating tumor cells (CTCs) as biomarkers demonstrates a promising solution to tackle the challenge, because CTCs play a critical role in cancer metastatic process via intravasation, circulation, extravasation, and formation of secondary tumor. However, the effectiveness of the solution is compromised by rarity, heterogeneity, and vulnerability associated with CTCs. Among a plethora of novel approaches for CTC isolation and enrichment, microfluidics leads to isolation and detection of CTCs in a cost-effective and operation-friendly way. Development of microfluidics also makes it feasible to model the cancer metastasis in vitro using a microfluidic system to mimick the in vivo microenvironment, thereby enabling analysis and monitor of tumor metastasis. This paper aims to review the latest advances for exploring the dual-roles microfluidics has played in early cancer diagnosis via CTC isolation and investigating the role of CTCs in cancer metastasis; the merits and drawbacks for dominating microfluidics-based CTC isolation methods are discussed; biomimicking cancer metastasis using microfluidics are presented with example applications on modelling of tumor microenvironment, tumor cell dissemination, tumor migration, and tumor angiogenesis. The future perspectives and challenges are discussed.

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“…By the digital camera, an inexpensive smartphone could take a photograph for the sample under rapid analysis at anytime and anywhere . Today, this idea has been applied to various analyses, such as bloodstains , pH , methamphetamine and soil color . However, until now, the field of smartphones‐based detection of chiral pollutants still remains unexplored.…”

Section: Introductionmentioning

confidence: 99%

Smartphone‐based colorimetric chiral recognition of ibuprofen using aptamers‐capped gold nanoparticles

Jing

Liu

et al. 2017

Electrophoresis

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Sensitive and fast detection of ibuprofen enantiomers is very critical for required routine monitoring and risk assessment of trace pollutants in water samples. Here a simple, rapid and highly sensitive android smartphone application for chiral recognition was developed. Aptamer-capped gold nanoparticles (AuNPs) was demonstrated as an efficient detection platform for (S)-(+)-ibuprofen (S-Ibu) and (R)-(-)-ibuprofen (R-Ibu). Detachment of an enantioselective aptamer from the AuNPs surface and binding with an enantiomer of Ibu lead to AuNPs aggregation, which allows a rapid enantiodiscrimination of Ibu by monitoring the absorbance changes of AuNPs solution in the UV-vis spectrum. Under optimal conditions, the limit of detection for S-Ibu and R-Ibu was 1.24 and 3.91 pg/mL, respectively. These probes showed good chiral recognition ability in mixed samples (i.e. S-Ibu + R-Ibu) and environmental samples. These advantages can be further developed by quantitative measurement with smartphone, which opens new opportunities for on-site detection of trace chiral pollutants in a simple and practical manner.

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An ultrasensitive method of real time pH monitoring with complementary metal oxide semiconductor image sensor

Cited by 33 publications

References 36 publications

Recent approaches for optical smartphone sensing in resource-limited settings: a brief review

Recent approaches for optical smartphone sensing in resource-limited settings: a brief review

Microfluidic applications on circulating tumor cell isolation and biomimicking of cancer metastasis

Smartphone‐based colorimetric chiral recognition of ibuprofen using aptamers‐capped gold nanoparticles

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