An ultrasensitive label-free immunosensor based on CdS sensitized Fe–TiO2 with high visible-light photoelectrochemical activity

Fan, Dawei; Wu, Dan; Cui, Jiali; Chen, Yu‐Cheng; Ma, Hongmin; Liu, Yixin; Wei, Qin; Du, Bin

doi:10.1016/j.bios.2015.07.034

Cited by 42 publications

(16 citation statements)

References 49 publications

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“…Ascorbic acid is oxidized at the working electrode/electrolyte interface by the holes in the valence band of TiO 2 . This action generates a measurable anodic PEC current (Figure 6, inset) (Fan et al, 2015). Figure 5b shows a summary of the average photocurrent density generated by tested samples and their standard deviation.…”

Section: Resultsmentioning

confidence: 99%

Surface modification of TiO₂ for photoelectrochemical DNA biosensors

et al. 2020

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A photoelectrochemical (PEC) DNA biosensor is developed using surface‐modified TiO2 nanoparticles (NPs) as a sensitive transducer. Different catecholates and gallates are used as sensitizers for TiO2 NPs. The molecules are adsorbed on TiO2 via the catecholate type bonding mechanism to enhance light absorption in the visible range. The adsorbed molecules act as charge transfer mediators and enhance photocurrent. Despite the similar bonding mechanism of the molecules, the TiO2 NPs exhibit significant differences in photocurrent. The modified TiO2 films showed photocurrent increase in the order: 3,4‐dihydroxy‐L‐phenylalanine < 2,3,4‐trihydroxybenzoic acid < 3,4‐dihydroxybenzoic acid < 2,3,4‐trihydroxybenzaldehyde < 3,4‐dihydroxyphenylacetic acid < 3,4‐dihydroxybenzaldehyde < caffeic acid. Testing results provide an insight into the influence of the structure and properties of the organic molecules on their adsorption and photocurrents of modified TiO2 films. The TiO2 NPs modified with caffeic acid are used for the fabrication of PEC DNA biosensor by forming photoelectrodes and immobilizing probe single‐stranded DNA on their surface. The caffeic acid‐modified TiO2‐based photoelectrodes offer the required signal magnitude to distinguish between complementary and non‐complementary DNA sequences in the 100 nM–1 pM DNA concentration range and with a limit of detection of 1.38 pM, paving the way towards PEC DNA sensing.

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Section: Resultsmentioning

confidence: 99%

Surface modification of TiO₂ for photoelectrochemical DNA biosensors

et al. 2020

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“…However, TiO 2 presents a large band gap with strong absorption in UV region as well as sluggish kinetic of generating electron‐hole pairs . Therefore, a number of photoactive materials based on TiO 2 combined to other inorganic semiconductors and organic dyes compounds have been proposed. For example, Zhang et al., developed photoelectrochemical sensors employing TiO 2 sensitized with Hemin and CdSe‐DNA .…”

Section: Introductionmentioning

confidence: 93%

Light‐emitting Diode‐assisted Determination of 2‐(1,1‐Dimethylethyl)‐1,4‐Benzenediol in Cosmetic Samples Exploiting TiO₂ Sensitized with Lithium 7,7′,8,8′‐Tetracyanoquinodimethanide

et al. 2018

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This paper reports a novel analytical device for the determination of 2‐(1,1‐dimethylethyl)‐1,4‐benzenediol antioxidant (TBHQ) in cosmetic samples exploiting a photoelectrochemical sensor based on titanium dioxide nanoparticles sensitized with lithium 7,7′,8,8′‐tetracyanoquinodimethanide on indium tin oxide electrode. The proposed photoelectrochemical sensor possesses the capacity of harvesting light energy from a commercial light‐emitting diode (LED) lamp for the determination of TBHQ molecules. The photoelectrochemical sensor presented photocurrent response to antioxidant about 2‐fold higher than pure titanium dioxide. The sensor shows high photocurrent response to TBHQ antioxidant in comparison to photocurrent response to 2,3‐t‐butyl‐4‐hydroxyanisole and 2,6‐Di‐tert‐butyl‐4‐methylphenol, indicating selectivity to TBHQ. Under optimized experimental conditions, the photoelectrochemical sensor presents two linear ranges of response for the analyte, the former from 0.6 to 200 μmol L−1, and the latter from 200 to 5000 μmol L−1. A low limit of detection of 0.17 μmol L−1 was obtained for the proposed photoelectrochemical sensor. The sensor was successfully employed to the analysis of cosmetic samples, with recovery values between 96 % and 98 %.

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“…In addition, rough surfaces of Fe-TiO 2 NPs are suitable for sufficient binding of carboxyl functionalized CdS NPs. 136 PEC biosensors can be integrated with other detection methods to create biosensors with desired properties and behaviors. For example, Bernacka-Wojcik et al developed a disposable biosensor by combining dyesensitized solar cells (DSSCs), in which TiO 2 nanoparticulate films were used as a photoanode and colorimetric DNA detection method for sensing specific DNA sequence from Mycobacterium tuberculosis.…”

Section: Biosensors Based On Tiomentioning

confidence: 99%

<p>Biomedical Applications of TiO<sub>2</sub> Nanostructures: Recent Advances</p>

Jafari¹,

Mahyad²,

Hashemzadeh³

et al. 2020

IJN

261

116

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Titanium dioxide (TiO 2) nanostructures are one of the most plentiful compounds that have emerged in various fields of technology such as medicine, energy and biosensing. Various TiO 2 nanostructures (nanotubes [NTs] and nanowires) have been employed in photoelectrochemical (PEC) biosensing applications, greatly enhancing the detection of targets. TiO 2 nanostructures, used as reinforced material or coatings for the bare surface of titanium implants, are excellent additive materials to compensate titanium implants deficiencies-like poor surface interaction with surrounding tissues-by providing nanoporous surfaces and hierarchical structures. These nanostructures can also be loaded by diversified drugs-like osteoporosis drugs, anticancer and antibiotics-and used as local drug delivery systems. Furthermore, TiO 2 nanostructures and their derivatives are new emerging antimicrobial agents to overcome human pathogenic microorganisms. However, like all other nanomaterials, toxicity and biocompatibility of TiO 2 nanostructures must be considered. This review highlights recent advances, along with the properties and numerous applications of TiO 2-based nanostructure compounds in nano biosensing, medical implants, drug delivery and antibacterial fields. Moreover, in the present study, some recent advances accomplished on the pharmaceutical applications of TiO 2 nanostructures, as well as its toxicity and biocompatibility, are presented.

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An ultrasensitive label-free immunosensor based on CdS sensitized Fe–TiO2 with high visible-light photoelectrochemical activity

Cited by 42 publications

References 49 publications

Surface modification of TiO₂ for photoelectrochemical DNA biosensors

Surface modification of TiO₂ for photoelectrochemical DNA biosensors

Light‐emitting Diode‐assisted Determination of 2‐(1,1‐Dimethylethyl)‐1,4‐Benzenediol in Cosmetic Samples Exploiting TiO₂ Sensitized with Lithium 7,7′,8,8′‐Tetracyanoquinodimethanide

<p>Biomedical Applications of TiO<sub>2</sub> Nanostructures: Recent Advances</p>

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An ultrasensitive label-free immunosensor based on CdS sensitized Fe–TiO2 with high visible-light photoelectrochemical activity

Cited by 42 publications

References 49 publications

Surface modification of TiO2 for photoelectrochemical DNA biosensors

Surface modification of TiO2 for photoelectrochemical DNA biosensors

Light‐emitting Diode‐assisted Determination of 2‐(1,1‐Dimethylethyl)‐1,4‐Benzenediol in Cosmetic Samples Exploiting TiO2 Sensitized with Lithium 7,7′,8,8′‐Tetracyanoquinodimethanide

<p>Biomedical Applications of TiO<sub>2</sub> Nanostructures: Recent Advances</p>

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Surface modification of TiO₂ for photoelectrochemical DNA biosensors

Surface modification of TiO₂ for photoelectrochemical DNA biosensors

Light‐emitting Diode‐assisted Determination of 2‐(1,1‐Dimethylethyl)‐1,4‐Benzenediol in Cosmetic Samples Exploiting TiO₂ Sensitized with Lithium 7,7′,8,8′‐Tetracyanoquinodimethanide