An ultrasensitive and preprocessing-free electrochemical platform for the detection of doxorubicin based on tryptophan/polyethylene glycol-cobalt ferrite nanoparticles modified electrodes

Abbasi, Mehrshad; Ezazi, Mona; Jouyban, Abolghasem; Lulek, Elif; Asadpour‐Zeynali, Karim; Ertaş, Yavuz Nuri; Houshyar, Jalil; Mokhtarzadeh, Ahad; Soleymani, Jafar

doi:10.1016/j.microc.2022.108055

Cited by 7 publications

(5 citation statements)

References 40 publications

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“…In addition, the absorption bands at 1086 cm – 1 are the result of the bending vibration of the C–O–C bond . These results corroborate the coating and adhesion of PEG to the surfaces of the Zn ferrite NPs, and Table provides a description of the bands of Zn ferrite and PEG@Zn ferrite NPs. ,, …”

Section: Methodssupporting

confidence: 69%

“…63 These results corroborate the coating and adhesion of PEG to the surfaces of the Zn ferrite NPs, and Table 2 provides a description of the bands of Zn ferrite and PEG@Zn ferrite NPs. 29,69,70 The observed FESEM results reveal that the produced Zn ferrite NPs had a spherical form (Figure 4a). The aggregation in the FESEM images is the result of magnetic NP interactions, which have been documented before for many other nanocrystalline spinel ferrites.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Engineered Polyethylene Glycol-Coated Zinc Ferrite Nanoparticles as a Novel Magnetic Resonance Imaging Contrast Agent

Dabagh

Haris

Ertaş

2023

ACS Biomater. Sci. Eng.

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Polyethylene glycol (PEG) was utilized to functionalize the surface of zinc ferrite nanoparticles (NPs) synthesized by the hydrothermal process in order to prevent aggregation and improve the biocompatibility of the NPs for the proposed magnetic resonance imaging (MRI) agent. Various spectroscopy techniques were used to examine the NPs’ structure, size, morphology, and magnetic properties. The NPs had a cubic spinel structure with an average size of 8 nm. The formations of the spinel ferrite and the PEG coating band at the ranges of 300–600 and 800–2000 cm–1, respectively, were validated by Fourier-transform infrared spectroscopy. The NPs were spherical in shape, and energy-dispersive X-ray spectroscopy with mapping confirmed the presence of zinc, iron, and oxygen in the samples. The results of high-resolution transmission electron microscopy revealed an average size of 14 nm and increased stability after PEG coating. The decrease in zeta potential from −24.5 to −36.5 mV confirmed the PEG coating on the surface of the NPs. A high saturation magnetization of ∼50 emu/g, measured by vibration sample magnetometer, indicated the magnetic potential of NPs for biomedical applications. An MTT assay was used to examine the cytotoxicity and viability of human normal skin cells (HSF 1184) exposed to zinc ferrite and PEG@Zn ferrite NPs at various concentrations. After 24 h of treatment, negligible cytotoxicity of PEG-coated NPs was observed at high concentrations. Magnetic resonance imaging (MRI) suggested that PEG@Zn ferrite NPs are a unique and perfectly suited contrast agent for T2-weighted MRI and can successfully enhance the image contrast.

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Section: Methodssupporting

confidence: 69%

Section: ■ Materials and Methodsmentioning

confidence: 99%

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Engineered Polyethylene Glycol-Coated Zinc Ferrite Nanoparticles as a Novel Magnetic Resonance Imaging Contrast Agent

Dabagh

Haris

Ertaş

2023

ACS Biomater. Sci. Eng.

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“…The following supporting information can be downloaded at: https:// www.mdpi.com/article/10.3390/nano13162369/s1, Figure S1: The dependence of the polyPhTz peak currents on the incubation of the GCE/polyPhTz sensors in water and HEPES; cyclic voltammograms recorded with intermediate stirring the solution; Figure S2: The dependence of the polyPhTz peak currents on the incubation time; Figure S3: Cyclic voltammograms recorded after incubation of the GCE/polyPhTz/DNA sensor in doxorubicin solution; Figure S4: Anodic peak currents on cyclic voltammograms recorded after incubation of the GCE/polyPhTz/DNA sensor in doxorubicin solution within the storage period in the buffer and in dry conditions; Table S1: Analytical characteristics of the determination of doxorubicin with electrochemical sensors and DNA sensors. References [72][73][74][75][76][77][78][79][80][81][82][83][84][85][86][87] are cited in the supplementary materials. Institutional Review Board Statement: Not applicable.…”

Section: Supplementary Materialsmentioning

confidence: 99%

Voltammetric Sensor for Doxorubicin Determination Based on Self-Assembled DNA-Polyphenothiazine Composite

Malanina,

Kuzin,

Khadieva

et al. 2023

Nanomaterials

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A novel voltammetric sensor based on a self-assembled composite formed by native DNA and electropolymerized N-phenyl-3-(phenylimino)-3H-phenothiazin-7-amine has been developed and applied for sensitive determination of doxorubicin, an anthracycline drug applied for cancer therapy. For this purpose, a monomeric phenothiazine derivative has been deposited on the glassy carbon electrode from the 0.4 M H2SO4-acetone mixture (1:1 v/v) by multiple potential cycling. The DNA aliquot was either on the electrode modified with electropolymerized film or added to the reaction medium prior to electropolymerization. The DNA entrapment and its influence on the redox behavior of the underlying layer were studied by scanning electron microscopy and electrochemical impedance spectroscopy. The DNA–doxorubicin interactions affected the charge distribution in the surface layer and, hence, altered the redox equilibrium of the polyphenothiazine coating. The voltametric signal was successfully applied for the determination of doxorubicin in the concentration range from 10 pM to 0.2 mM (limit of detection 5 pM). The DNA sensor was tested on spiked artificial plasma samples and two commercial medications (recovery of 90–95%). After further testing on real clinical samples, the electrochemical DNA sensor developed can find application in monitoring drug release and screening new antitumor drugs able to intercalate DNA.

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“…Compared with these classical analytical methods, electrochemical sensors have the advantages of low cost, fast response and simple operation, and are suitable for the rapid detection of DOX in environmental waters [14][15][16]. DOX is susceptible to redox reactions on the electrode surface due to its electrochemically active groups (quinone, hydroxyquinone) [17]. Therefore, researchers have mostly focused on modifying electrodes using nanomaterials to improve the detection sensitivity of the DOX sensors [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Label-Free Detection of Doxorubicin in Lake Water by an Electrochemical Aptamer Biosensor

Luo,

Wang,

et al. 2023

J. Adv. Biotechnol. Bioeng.

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The application of electrochemical sensors to the detection of real samples is hampered by the fact that the electrode surface is often prone to adsorption of other substances that cause a non-specific current response. In addition, electroactive substances in the actual sample are prone to redox reactions on the electrode surface and affect the detection of target molecules. In this paper, we constructed a novel DOX sensor with excellent selectivity using an aptamer-modified gold electrode and used it for the label-free rapid detection of DOX in lake water. DOX molecules in solution can be captured by the aptamers immobilised on the surface of the gold electrode, followed by the DOX molecules getting electrons on the surface of the electrode and undergoing a reduction reaction. Aptamers give electrochemical sensors excellent sensitivity and selectivity. Finally, the electrochemical aptamer biosensor was successfully applied to detect DOX in lake water with a detection limit of 30 nmol/L and a detection range of 30 nmol/L–10 μmol/L.

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An ultrasensitive and preprocessing-free electrochemical platform for the detection of doxorubicin based on tryptophan/polyethylene glycol-cobalt ferrite nanoparticles modified electrodes

Cited by 7 publications

References 40 publications

Engineered Polyethylene Glycol-Coated Zinc Ferrite Nanoparticles as a Novel Magnetic Resonance Imaging Contrast Agent

Engineered Polyethylene Glycol-Coated Zinc Ferrite Nanoparticles as a Novel Magnetic Resonance Imaging Contrast Agent

Voltammetric Sensor for Doxorubicin Determination Based on Self-Assembled DNA-Polyphenothiazine Composite

Label-Free Detection of Doxorubicin in Lake Water by an Electrochemical Aptamer Biosensor

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