An ultra-high-performance chromatography method to study the long term stability of gemcitabine in dose banding conditions

Closset, Mélanie; Colsoul, Marie-Lise; Goderniaux, Nicolas; Bihin, Benoît; Jamart, Jacques; Onorati, Sabrina; Soumoy, Laura; Hecq, Jean-Daniel; Odou, Pascal; Galanti, Laurence

doi:10.1016/j.jpba.2023.115290

Journal of Pharmaceutical and Biomedical Analysis

2023

DOI: 10.1016/j.jpba.2023.115290

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An ultra-high-performance chromatography method to study the long term stability of gemcitabine in dose banding conditions

Mélanie Closset

Marie-Lise Colsoul

Nicolas Goderniaux

et al.

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“…7 Therefore, it is important to monitor the plasma concentration of GMB to optimize the therapy and avoid side effects, such as toxicity or reduced effectiveness. 8 Several techniques have been used for the analysis of GMB, such as chromatographic techniques, including HPLC, 9 LC/MS/MS, 10,11 GC-MS, 12 and fluorescence sensor. 13 These methods can quantify GMB in blood, urine, and tissues with high sensitivity, specificity, and accuracy.…”

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A Sensitive Electrochemical DNA Biosensor for Determination of Anti-Cancer Drug Gemcitabine Based on an AuNPs/MWCNTs/Carbon Paste Electrode

Mohammadi,

Rafati,

Bagheri

2023

J. Electrochem. Soc.

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GMB is a common anticancer drug that needs careful monitoring because of its variable and toxic effects. Detecting GMB in biological samples can help adjust the dosage and enhance the treatment outcomes. In this study, a novel electrochemical sensor was developed based on a carbon paste electrode modified with single stranded DNA, gold nanoparticles and multi-walled carbon nanotubes. We characterized the unmodified (bare CPE) and modified (ss-DNA/AuNPs/MWCNTs/CPE) electrodes using scanning electron microscopy SEM, EDX analysis and cyclic voltammetry (CV) techniques. The oxidation peak current was linearly proportional to the GMB concentration in two linear ranges: 1-10 and 10-50 µM, with a detection limit of 0.52 µM and a limit of quantification of 1.75 µM. The lower linear concentration range (1-10 µM) showed a sensitivity of 5.68 A.M-1.cm-2, while the higher range (10-50 µM) showed a sensitivity of 1.34 A.M-1.cm-2. We also investigated the repeatability, applicability and reproducibility of this method for human serum samples. We tested the selectivity and practical ability of the ss-DNA/AuNPs/MWCNTs/CPE for the determination of GMB in the presence of various interfering species and human serum samples. The results indicated that the ss-DNA/AuNPs/MWCNTs/CPE was a selective, reliable and accurate electrochemical sensor for GMB.

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A Sensitive Electrochemical DNA Biosensor for Determination of Anti-Cancer Drug Gemcitabine Based on an AuNPs/MWCNTs/Carbon Paste Electrode

Mohammadi,

Rafati,

Bagheri

2023

J. Electrochem. Soc.

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An ultra-high-performance chromatography method to study the long term stability of gemcitabine in dose banding conditions

Cited by 1 publication

References 21 publications

A Sensitive Electrochemical DNA Biosensor for Determination of Anti-Cancer Drug Gemcitabine Based on an AuNPs/MWCNTs/Carbon Paste Electrode

A Sensitive Electrochemical DNA Biosensor for Determination of Anti-Cancer Drug Gemcitabine Based on an AuNPs/MWCNTs/Carbon Paste Electrode

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