An Ulcer by Any Other Name

Gravett, Ronnie M; Marrazzo, Jeanne

doi:10.1016/j.idc.2023.02.005

Cited by 2 publications

(1 citation statement)

References 77 publications

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“…Chronic wounds are typically defined as wounds that fail to heal or show no tendency to heal after more than 1 month of standard treatment and have entered a pathological inflammatory response state. 1 , 2 Common chronic wounds include diabetic foot ulcers, 3 pressure ulcers, 4 infectious ulcers 5 and cancerous ulcers. 6 Patients with these types of wounds often require long hospital stays, frequent dressing changes and multiple debridement surgeries, yet the clinical outcomes are often poor, leading to severe deformities, disabilities and even amputations.…”

Section: Introductionmentioning

confidence: 99%

Effect of platelet‐rich plasma combined with negative pressure wound therapy in treating patients with chronic wounds: A meta‐analysis

Chen,

Xu,

et al. 2024

International Wound Journal

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A meta‐analysis was conducted to comprehensively explore the effects of platelet‐rich plasma (PRP) combined with negative pressure wound therapy (NPWT) in treating patients with chronic wounds. Computer searches were conducted, from database infection to November 2023, in EMBASE, Google Scholar, Cochrane Library, PubMed, Wanfang and China National Knowledge Infrastructure databases for randomized controlled trials (RCTs) on the use of PRP combined with NPWT technology for treating chronic wounds. Two researchers independently screened the literature, extracted data and conducted quality assessments according to the inclusion and exclusion criteria. Stata 17.0 software was employed for data analysis. Overall, 18 RCTs involving 1294 patients with chronic wounds were included. The analysis revealed that, compared with NPWT alone, the use of PRP combined with NPWT technology significantly improved the healing rate (odds ratios [OR] = 1.92, 95% confidence intervals [CIs]: 1.43–2.58, p < 0.001) and total effective rate (OR = 1.31, 95% CI: 1.23–1.39, p < 0.001), and also significantly shortened the healing time of the wound (standardized mean difference = −2.01, 95% CI: −2.58 to −1.45, p < 0.001). This study indicates that the treatment of chronic wounds with PRP combined with NPWT technology can significantly enhance clinical repair effectiveness and accelerate wound healing, with a high healing rate, and is worth further promotion and practice.

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Section: Introductionmentioning

confidence: 99%

Effect of platelet‐rich plasma combined with negative pressure wound therapy in treating patients with chronic wounds: A meta‐analysis

Chen,

Xu,

et al. 2024

International Wound Journal

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Chancroid: A Tenacious Old Foe of Mankind – Two Cases from the Foothills of the Himalayas

Singh,

Bhatia,

Kaistha

et al. 2024

J. Pure Appl. Microbiol.

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Sexually transmitted infections are a common problem worldwide. A typical presentations may sometimes occur so Chancroid should always be kept in mind as a differential diagnosis while dealing with genital ulcer disease (GUD) patients as Microbiological evidence may not always be available. We present two cases with GUD. Swabs were collected from the base and margins of the penile ulcers and sent to the bacteriology laboratory for Gram staining and aerobic routine culture. Gram-stained smears revealed numerous Gram-negative coccobacilli in a typical railroad track/school of fish appearance suggestive of Haemophilus ducreyi infection. No growth was observed on aerobic routine culture. The patients were started on single-dose azithromycin as per National AIDS Control Organisation (NACO) guidelines. Remarkable clinical improvement was observed in both patients on follow-up.

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An Ulcer by Any Other Name

Cited by 2 publications

References 77 publications

Effect of platelet‐rich plasma combined with negative pressure wound therapy in treating patients with chronic wounds: A meta‐analysis

Effect of platelet‐rich plasma combined with negative pressure wound therapy in treating patients with chronic wounds: A meta‐analysis

Chancroid: A Tenacious Old Foe of Mankind – Two Cases from the Foothills of the Himalayas

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