An RXLR effector targets ER-Golgi interface to induce ER stress and necrotic cell death
Jihyun Kim,
Jesse Kaleku,
Jongchan Woo
et al.
Abstract:To achieve successful colonization, the pathogen secretes hundreds of effectors into host cells to manipulate the host’s immune response. Despite numerous studies, the molecular mechanisms underlying effector-induced necrotic cell death remain elusive. In this study, we identified a novel virulent RXLR effector named Pc12 fromP. capsici.Pc12 induces necrosis by triggering a distinct ER stress response through its interaction with Rab13-2. Unlike conventional hypersensitive response cell death associated with e… Show more
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