An ROS-Responsive Antioxidative Macromolecular Prodrug of Caffeate for Uveitis Treatment

Natural products applied in acute kidney injury treatment: polymer matters

“…Caffeic acid and its esters are compounds found in several natural medicinal plants and proved to suppress the activation of the NFκB pathway with downstream inflammatory mediators. 101,102 In our research group, we integrated injured kidney-targeted l -serine with antioxidative ethyl caffeate (EC) by the host–guest interaction of polyglutamic acid decorated with adamantane and β-cyclodextrin separately. 92 EC was conjugated via ROS-responsive phenylboronate esters to release 4-hydroxybenzyl alcohol as a byproduct after stimulation, which was a fair antioxidant itself.…”

ROS-responsive & scavenging NO nanomedicine for vascular diseases treatment by inhibiting endoplasmic reticulum stress and improving NO bioavailability

“…This polymeric micelle had combined antioxidant capability and achieved a great therapeutic effect on atherosclerosis [ 31 ]. Previously, our group developed a new method to synthesize boronic acid esters [ [32] , [33] , [34] ]. Ethyl caffeate (ECA), a key ingredient of Chinese herb, has potent ability of relieving oxidative stress.…”

A Sequential Dual Functional Supramolecular Hydrogel with Promoted Drug Release to Scavenge ROS and Stabilize HIF‐1α for Myocardial Infarction Treatment

“…The disulfide bonds are able to scavenge the overproduced ROS in the damaged heart, then promoting the hydrolysis of ester bond in prodrugs. [28][29][30][31][32] Subsequently, the DPCA would be sustainingly released from the cavity of CSAC4A to maintain the expression of HIF-1𝛼 and inhibit the proliferation of CFs (Scheme 1). The dual-crosslinking network further promotes the sustainable release of DPCA.…”