An RNA foundation model enables discovery of disease mechanisms and candidate therapeutics
Brendan Frey,
Albi Celaj,
Alice Gao
et al.
Abstract:Accurately modeling and predicting RNA biology has been a long-standing challenge, bearing significant clinical ramifications for variant interpretation and the formulation of tailored therapeutics. We describe a foundation model for RNA biology, “BigRNA”, which was trained on thousands of genome-matched datasets to predict tissue-specific RNA expression, splicing, microRNA sites, and RNA binding protein specificity from DNA sequence. Unlike approaches that are restricted to missense variants, BigRNA can ide… Show more
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