An RFC4/Notch1 signaling feedback loop promotes NSCLC metastasis and stemness

Liu, Lei; Tao, Tianyu; Liu, Shihua; Yang, Xia; Chen, Xuwei; Liang, Jiaer; Hong, Ruohui; Wang, Wenting; Yang, Yi; Li, Xiaohua; Zhang, Youhong; Li, Quanfeng; Liang, Shujun; Yu, Haocheng; Wu, Yun; Guo, Xinyu; Lai, Yan H.; Ding, Xueliang; Guan, Hongyu; Wu, Jueheng; Zhu, Xun; Yuan, Jie; Li, Jun; Su, Shicheng; Li, Mengfeng; Cai, Junchao; Tian, Han

doi:10.1038/s41467-021-22971-x

Cited by 57 publications

(40 citation statements)

References 52 publications

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“…The expression of FBXW7 shows a significant correlation with the treatment outcome of non-small cell lung cancer (NSCLC) [ 114 – 116 ]. Whole-exome sequencing and comprehensive immunoassays of early-stage lung squamous carcinoma reveals a significant decrease in FBXW7 expression levels, suggesting that FBXW7 may be one of the key factors influencing the progression of lung squamous carcinoma [ 115 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical significance of FBXW7 loss of function in human cancers

Fan

Bellon

et al. 2022

Mol Cancer

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FBXW7 (F-Box and WD Repeat Domain Containing 7) (also referred to as FBW7 or hCDC4) is a component of the Skp1-Cdc53 / Cullin-F-box-protein complex (SCF/β-TrCP). As a member of the F-box protein family, FBXW7 serves a role in phosphorylation-dependent ubiquitination and proteasome degradation of oncoproteins that play critical role(s) in oncogenesis. FBXW7 affects many regulatory functions involved in cell survival, cell proliferation, tumor invasion, DNA damage repair, genomic instability and telomere biology. This thorough review of current literature details how FBXW7 expression and functions are regulated through multiple mechanisms and how that ultimately drives tumorigenesis in a wide array of cell types. The clinical significance of FBXW7 is highlighted by the fact that FBXW7 is frequently inactivated in human lung, colon, and hematopoietic cancers. The loss of FBXW7 can serve as an independent prognostic marker and is significantly correlated with the resistance of tumor cells to chemotherapeutic agents and poorer disease outcomes. Recent evidence shows that genetic mutation of FBXW7 differentially affects the degradation of specific cellular targets resulting in a distinct and specific pattern of activation/inactivation of cell signaling pathways. The clinical significance of FBXW7 mutations in the context of tumor development, progression, and resistance to therapies as well as opportunities for targeted therapies is discussed.

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Section: Introductionmentioning

confidence: 99%

Clinical significance of FBXW7 loss of function in human cancers

Fan

Bellon

et al. 2022

Mol Cancer

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“…Notably, NICD can translocate into the nucleus, where it allows for the attachment of the DNA-binding transcription factor, RBP-Jκ, resulting in the transcription of HES1, HES5, and HEY1, which subsequently suppresses differentiation. 34 Here, HDAC11 also caused the release of the intracellular domain of the Notch protein (NICD), which may have led to the formation of a HDAC11−NICD− RBP-Jκ ternary complex that stimulates transcription of key Notch targets for inhibiting myogenic differentiation. In addition, we demonstrated that overexpression of HDAC11 inhibited muscle regeneration using muscle-injured mice, and this may be related to the inhibition of MuSC myogenic differentiation by HDAC11.…”

Section: ■ Discussionmentioning

confidence: 99%

HDAC11 Regulates the Proliferation of Bovine Muscle Stem Cells through the Notch Signaling Pathway and Inhibits Muscle Regeneration

Zhang

Pan

Feng

et al. 2022

J. Agric. Food Chem.

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Myogenesis is an essential process that can affect the yield and quality of beef. Transcriptional studies have shown that histone deacetylase 11 (HDAC11) was differentially expressed in muscle tissues of 6 and 18 month old Longlin cattle, but its role in the regulation of myogenesis remains unclear. This study aimed to determine the role of HDAC11 in the proliferation and differentiation of bovine muscle stem cells (MuSCs). HDAC11 promoted MuSC proliferation by activating Notch signaling and inhibited myoblast differentiation by reducing MyoD1 transcription. In addition, overexpression of HDAC11 inhibited the repair regeneration process of muscle in mice. HDAC11 was found to be a novel key target for the control of myogenesis, and this is a theoretical basis for the development of HDAC11-specific modulators as a new strategy to regulate myogenesis.

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“…RFC4 is a known subunit of the replication factor C complex, which functions mainly in DNA replication [ 27 ]. Many reports have shown that RFC4 may play an important role in the proliferation, progression, invasion, and metastasis of cancer cells [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

The upregulated expression of RFC4 and GMPS mediated by DNA copy number alteration is associated with the early diagnosis and immune escape of ESCC based on a bioinformatic analysis

Wang

Luo

Huang

et al. 2021

Aging

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Esophageal squamous cell carcinoma (ESCC) is a malignant tumor that commonly occurs worldwide. Usually, Asia, especially China, has a high incidence of esophageal cancer. ESCC often has a poor outcome because of a late diagnosis and lack of effective treatments. To build foundations for the early diagnosis and treatment of ESCC, we used the gene expression datasets GSE20347 and GSE17351 from the GEO database and a private dataset to uncover differentially expressed genes (DEGs) and key genes in ESCC. Notably, we found that replication factor C subunit 4 (RFC4) and guanine monophosphate synthase (GMPS) were upregulated but have been rarely studied in ESCC. In particular, to the best of our knowledge, our study is the first to explore GMPS and ESCC. Furthermore, we found that high levels of RFC4 and GMPS expression may result from an increase in DNA copy number alterations. Furthermore, RFC4 and GMPS were both upregulated in the early stage and early nodal metastases of esophageal carcinoma. The expression of RFC4 was strongly correlated with GMPS. In addition, we explored the relationship between RFC4 and GMPS expression and tumor-infiltrating immune cells (TILs) in esophageal carcinoma. The results showed that the levels of RFC4 and GMPS increased with a decrease in some tumor-infiltrating cells. Upregulated RFC4 and GMPS with high TILs indicate a worse prognosis. In summary, our study shows that RFC4 and GMPS have potential as biomarkers for the early diagnosis of ESCC and may played a crucial role in the process of tumor immunity in ESCC.

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An RFC4/Notch1 signaling feedback loop promotes NSCLC metastasis and stemness

Cited by 57 publications

References 52 publications

Clinical significance of FBXW7 loss of function in human cancers

Clinical significance of FBXW7 loss of function in human cancers

HDAC11 Regulates the Proliferation of Bovine Muscle Stem Cells through the Notch Signaling Pathway and Inhibits Muscle Regeneration

The upregulated expression of RFC4 and GMPS mediated by DNA copy number alteration is associated with the early diagnosis and immune escape of ESCC based on a bioinformatic analysis

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