An RCT of acute health effects in COPD-patients after passive vape exposure from e-cigarettes

Laursen, Karin Rosenkilde; Bønløkke, Jakob Hjort; Bendstrup, Elisabeth; Bilde, Merete; Glasius, Marianne; Gutzke, Vibeke Heitmann; Moosakutty, Shamjad P.; Olin, Anna‐Carin; Ravn, Peter; Østergaard, Kirsten; Sigsgaard, Torben

doi:10.1080/20018525.2020.1861580

Cited by 8 publications

(5 citation statements)

References 39 publications

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“…A randomized controlled trial examined the effects of passive ENDS aerosol exposure in patients who had COPD who were nonsmokers. 218 Passive e-cigarette exposure resulted in alterations in exhaled surfactant protein A and increases in certain plasma proteins that could indicate inflammation. 218 In a large cross-sectional telephone survey of never-smokers, the odds of self-reported asthma were higher in current ENDS users compared with nonusers.…”

Section: Chronic Health Effects Of E-cigarettes and Vaping Productsmentioning

confidence: 99%

“…218 Passive e-cigarette exposure resulted in alterations in exhaled surfactant protein A and increases in certain plasma proteins that could indicate inflammation. 218 In a large cross-sectional telephone survey of never-smokers, the odds of self-reported asthma were higher in current ENDS users compared with nonusers. 219 Similar survey studies have shown higher self-reported asthma and COPD in ENDS users.…”

Section: Chronic Health Effects Of E-cigarettes and Vaping Productsmentioning

confidence: 99%

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Cardiopulmonary Impact of Electronic Cigarettes and Vaping Products: A Scientific Statement From the American Heart Association

Rose¹,

Krishnan‐Sarin²,

Exil³

et al. 2023

Circulation

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Vaping and electronic cigarette (e-cigarette) use have grown exponentially in the past decade, particularly among youth and young adults. Cigarette smoking is a risk factor for both cardiovascular and pulmonary disease. Because of their more limited ingredients and the absence of combustion, e-cigarettes and vaping products are often touted as safer alternative and potential tobacco-cessation products. The outbreak of e-cigarette or vaping product use–associated lung injury in the United States in 2019, which led to >2800 hospitalizations, highlighted the risks of e-cigarettes and vaping products. Currently, all e-cigarettes are regulated as tobacco products and thus do not undergo the premarket animal and human safety studies required of a drug product or medical device. Because youth prevalence of e-cigarette and vaping product use was as high as 27.5% in high school students in 2019 in the United States, it is critical to assess the short-term and long-term health effects of these products, as well as the development of interventional and public health efforts to reduce youth use. The objectives of this scientific statement are (1) to describe and discuss e-cigarettes and vaping products use patterns among youth and adults; (2) to identify harmful and potentially harmful constituents in vaping aerosols; (3) to critically assess the molecular, animal, and clinical evidence on the acute and chronic cardiovascular and pulmonary risks of e-cigarette and vaping products use; (4) to describe the current evidence of e-cigarettes and vaping products as potential tobacco-cessation products; and (5) to summarize current public health and regulatory efforts of e-cigarettes and vaping products. It is timely, therefore, to review the short-term and especially the long-term implications of e-cigarettes and vaping products on cardiopulmonary health. Early molecular and clinical evidence suggests various acute physiological effects from electronic nicotine delivery systems, particularly those containing nicotine. Additional clinical and animal-exposure model research is critically needed as the use of these products continues to grow.

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Section: Chronic Health Effects Of E-cigarettes and Vaping Productsmentioning

confidence: 99%

Section: Chronic Health Effects Of E-cigarettes and Vaping Productsmentioning

confidence: 99%

Cardiopulmonary Impact of Electronic Cigarettes and Vaping Products: A Scientific Statement From the American Heart Association

Rose¹,

Krishnan‐Sarin²,

Exil³

et al. 2023

Circulation

View full text Add to dashboard Cite

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“…Levels of SP-A and albumin are typically assessed by bronchoalveolar lavage (BAL) or similar invasive methods, but new technology makes it possible to measure these proteins in droplets in exhaled air [ 32 , 33 ]. To date, the measurement of SP-A and albumin in exhaled air has not been studied in relation to exposure to air pollution, but effects on SP-A have been found in an exposure study of second-hand emissions from electronic cigarettes and in a cross-sectional study of smokers [ 38 , 39 ].…”

Section: Introductionmentioning

confidence: 99%

Airway and systemic biomarkers of health effects after short-term exposure to indoor ultrafine particles from cooking and candles – A randomized controlled double-blind crossover study among mild asthmatic subjects

et al. 2023

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Background There is insufficient knowledge about the systemic health effects of exposure to fine (PM2.5) and ultrafine particles emitted from typical indoor sources, including cooking and candlelight burning. We examined whether short-term exposure to emissions from cooking and burning candles cause inflammatory changes in young individuals with mild asthma. Thirty-six non-smoking asthmatics participated in a randomized controlled double-blind crossover study attending three exposure sessions (mean PM2.5 µg/m3; polycyclic aromatic hydrocarbons ng/m3): (a) air mixed with emissions from cooking (96.1; 1.1), (b) air mixed with emissions from candles (89.8; 10), and (c) clean filtered air (5.8; 1.0). Emissions were generated in an adjacent chamber and let into a full-scale exposure chamber where participants were exposed for five hours. Several biomarkers were assessed in relation to airway and systemic inflammatory changes; the primary outcomes of interest were surfactant Protein-A (SP-A) and albumin in droplets in exhaled air – novel biomarkers for changes in the surfactant composition of small airways. Secondary outcomes included cytokines in nasal lavage, cytokines, C-reactive protein (CRP), epithelial progenitor cells (EPCs), genotoxicity, gene expression related to DNA-repair, oxidative stress, and inflammation, as well as metabolites in blood. Samples were collected before exposure start, right after exposure and the next morning. Results SP-A in droplets in exhaled air showed stable concentrations following candle exposure, while concentrations decreased following cooking and clean air exposure. Albumin in droplets in exhaled air increased following exposure to cooking and candles compared to clean air exposure, although not significant. Oxidatively damaged DNA and concentrations of some lipids and lipoproteins in the blood increased significantly following exposure to cooking. We found no or weak associations between cooking and candle exposure and systemic inflammation biomarkers including cytokines, CRP, and EPCs. Conclusions Cooking and candle emissions induced effects on some of the examined health-related biomarkers, while no effect was observed in others; Oxidatively damaged DNA and concentrations of lipids and lipoproteins were increased in blood after exposure to cooking, while both cooking and candle emissions slightly affected the small airways including the primary outcomes SP-A and albumin. We found only weak associations between the exposures and systemic inflammatory biomarkers. Together, the results show the existence of mild inflammation following cooking and candle exposure.

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“…Currently, concerns about e-cigarette harms include negative impact on cardiovascular health [ 7 ] and potential hazards such as obstructive lung disease from flavorants in e-cigarettes [ 8 ]. Passive exposure to second hand aerosol (SHA) from e-cigarettes is also a cause for concern, especially among those with respiratory diseases such as COPD [ 9 , 10 ], and symptoms of sensory irritation, and general complaints have been reported by non-smokers [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Friends and family matter Most: a trend analysis of increasing e-cigarette use among Irish teenagers and socio-demographic, personal, peer and familial associations

2021

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Background E-cigarette ever-use and current-use among teenagers has increased worldwide, including in Ireland. Methods We use data from two Irish waves (2015, 2019) of the European School Survey Project on Alcohol and other Drugs (ESPAD) to investigate gender and teenage e-cigarette use (n = 3421 16-year-olds). Using chi-square analyses, we report changes in e-cigarette ever-use, current-use, and associated variables. Using multivariable logistic regression, we analyse the increase in e-cigarette use and socio-demographic, personal, peer and familial associations, focusing on gender differences. Results E-cigarette ever-use increased from 23% in 2015 to 37% in 2019, and current-use from 10 to 18%. Compared with 2015, the odds in 2019, of becoming both an e-cigarette ever-user and current-user, were significantly higher for girls than boys (ever-use: AOR 2.67 vs 2.04; current-use: AOR 3.11 vs 1.96). Smoking and e-cigarette use are linked but never-smokers who try e-cigarettes rose significantly from 33 to 67% and those using e-cigarettes to quit smoking decreased significantly from 17 to 3%. Almost two-thirds of respondents (66%) in 2019 said that their reason for trying e-cigarettes was “out of curiosity”. Peer smoking is significantly associated with likelihood of e-cigarette ever-use (AOR 6.52) and current-use (AOR 5.45). If “Most/All friends smoke”, odds were significantly higher for boys than for girls (ever-use AOR 7.07 vs 6.23; current-use AOR 5.90 vs 5.31). Less parental monitoring is significantly associated with greater e-cigarette ever-use (AOR 3.96) and current-use (4.48), and having parents who usually don’t know where their child is on Saturday nights was also associated with significantly higher odds for boys than for girls (ever-use AOR 5.42 vs 3.33; current-use AOR 5.50 vs 3.50). Conclusion Respondents had significantly higher odds of being e-cigarette ever- and current-users in 2019 compared with 2015. Use is higher among boys but girls are increasingly at risk. Two-thirds had never smoked cigarettes at first e-cigarette use; two-thirds used out of curiosity but few (3%) for smoking cessation. The most prominent risk factors for e-cigarette use were peer- and parent-related, especially so for boys. Interventions that take account of friend and family influences may provide mechanisms for preventing an increasing risk of nicotine addiction.

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An RCT of acute health effects in COPD-patients after passive vape exposure from e-cigarettes

Cited by 8 publications

References 39 publications

Cardiopulmonary Impact of Electronic Cigarettes and Vaping Products: A Scientific Statement From the American Heart Association

Cardiopulmonary Impact of Electronic Cigarettes and Vaping Products: A Scientific Statement From the American Heart Association

Airway and systemic biomarkers of health effects after short-term exposure to indoor ultrafine particles from cooking and candles – A randomized controlled double-blind crossover study among mild asthmatic subjects

Friends and family matter Most: a trend analysis of increasing e-cigarette use among Irish teenagers and socio-demographic, personal, peer and familial associations

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