An ovine Major histocompatibility complex DRB1 allele is associated with low faecal egg counts following natural, predominantly Ostertagia circumcincta infection

Schwaiger, Franz-Werner; Gostomski, D.; Stear, M. J.; Duncan, J.L.; McKellar, Quintin; Epplen, Jörg T.; Buitkamp, Johannes

doi:10.1016/0020-7519(94)00216-b

Cited by 146 publications

(135 citation statements)

References 35 publications

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“…Thus, replicating results in a second family where the polymorphism is not segregating is not possible. Polymorphisms may not be segregating in families due to low allele frequencies in the breed, or because the polymorphism is (Schwaiger et al, 1995 ;Outteridge et al, 1996;Paterson et al, 1998 ;Coltman et al, 2001 ;Patterson et al, 2001;Davies et al, 2006). However, this study found no validated SNP in these regions.…”

Section: Discussionmentioning

confidence: 53%

The distribution of SNP marker effects for faecal worm egg count in sheep, and the feasibility of using these markers to predict genetic merit for resistance to worm infections

et al. 2011

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SummaryGenetic resistance to gastrointestinal worms is a complex trait of great importance in both livestock and humans. In order to gain insights into the genetic architecture of this trait, a mixed breed population of sheep was artificially infected with Trichostrongylus colubriformis (n=3326) and then Haemonchus contortus (n=2669) to measure faecal worm egg count (WEC). The population was genotyped with the Illumina OvineSNP50 BeadChip and 48 640 single nucleotide polymorphism (SNP) markers passed the quality controls. An independent population of 316 sires of mixed breeds with accurate estimated breeding values for WEC were genotyped for the same SNP to assess the results obtained from the first population. We used principal components from the genomic relationship matrix among genotyped individuals to account for population stratification, and a novel approach to directly account for the sampling error associated with each SNP marker regression. The largest marker effects were estimated to explain an average of 0 . 48% (T. colubriformis) or 0 . 08 % (H. contortus) of the phenotypic variance in WEC. These effects are small but consistent with results from other complex traits. We also demonstrated that methods which use all markers simultaneously can successfully predict genetic merit for resistance to worms, despite the small effects of individual markers. Correlations of genomic predictions with breeding values of the industry sires reached a maximum of 0 . 32. We estimate that effective across-breed predictions of genetic merit with multi-breed populations will require an average marker spacing of approximately 10 kbp.

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Section: Discussionmentioning

confidence: 53%

The distribution of SNP marker effects for faecal worm egg count in sheep, and the feasibility of using these markers to predict genetic merit for resistance to worm infections

et al. 2011

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“…A number of studies have investigated QTL for internal nematode resistance in sheep [4,10,11,13,17,24,26]. However, the results of the studies differed in the chromosomal regions of interest that were identified to have significant associations with nematode resistance.…”

Section: Discussionmentioning

confidence: 99%

“…Most of them focused on single chromosomes [10,11,17,24,26], whereas Beh et al [4] undertook a full genome scan and looked for significant associations between chromosomal regions and indicator traits of internal nematode resistance across the whole ovine genome. The authors of the different studies do not mention if the phenotypic data were tested for normality and how this data characteristic was dealt with.…”

Section: Discussionmentioning

confidence: 99%

“…The MHC is located in the sheep genome on chromosome 20 [12]. Several studies have shown significant associations between regions on ovine chromosome 20 and indicator traits for internal nematode resistance [10,26].…”

Section: Qtl For Parasite Resistance In Sheepmentioning

confidence: 99%

“…The DRB1 locus [26] within the ovine MHC has been associated with resistance to Te. circumcincta in Scottish Blackface.…”

Section: Qtl For Parasite Resistance In Sheepmentioning

confidence: 99%

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Quantitative trait loci for internal nematode resistance in sheep: a review

Dominik¹

2005

Genet. Sel. Evol.

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-Internal nematode resistance in sheep has a large impact on the economy of sheep industries. Selection for nematode resistance in sheep breeding schemes would help to reduce the direct and indirect cost of parasitism to these industries. However, this is not widely practiced because of the difficulty of measuring parasite resistance or correlated indirect selection criteria. The identification of genes or linked markers that have a significant association with the variance of indicator traits of internal nematode resistance in sheep would facilitate the inclusion of nematode resistance in sheep breeding operations. This review summarises findings reported in the literature of quantitative trait loci for internal nematode resistance in sheep. Issues relating to the analytical and phenotypic complexity of nematode resistance are discussed in the context of the findings of quantitative trait loci for nematode resistance published to date.sheep / internal nematode resistance / quantitative trait loci

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Indirect DNA/gene diagnoses via electrophoresis – an obsolete principle?

et al. 1995

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In principle, gene defects can be investigated directly or indirectly via informative polymorphisms in their vicinity. But because many defects are not yet defined molecularly, these inherited diseases can only be diagnosed indirectly via analysis of informative family situations. Since (multiple) mutation analyses, e.g. via DNA sequencing, are time-consuming and expensive, indirect analysis may still be performed initially--particularly in diseases caused by heterogenous mutations. We focus on diagnoses of neurological and (auto)immune diseases by polymerase chain reaction and separation of the DNA fragments via gel electrophoreses. Even after gene defects have been identified, indirect analysis might be necessary, for example in Huntington's chorea. Although this genetic defect has been characterized as a trinucleotide disease, indirect DNA diagnosis is still performed in particular cases for psychological reasons. The causes of autoimmune diseases are multifactorial and the inheritance is complex, involving several genes. Genome-wide screening programs may involve indirect approaches via analyses of polymorphic microsatellites. Large parts of the immunological genome can be covered when 20 or more genes are investigated simultaneously. Thus the genetic bases of autoimmune diseases are disclosed. Microsatellites themselves could have a biological meaning. We therefore discuss also DNA/protein interactions for simple tandem repeats, the major targets for indirect gene diagnoses. Only indirect evidence exists that certain simple repeats influence genomic (in)stability. Taken together, indirect gene diagnoses supplement direct approaches in a variety of different purposes and in combination with standard electrophoresis techniques.

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An ovine Major histocompatibility complex DRB1 allele is associated with low faecal egg counts following natural, predominantly Ostertagia circumcincta infection

Cited by 146 publications

References 35 publications

The distribution of SNP marker effects for faecal worm egg count in sheep, and the feasibility of using these markers to predict genetic merit for resistance to worm infections

The distribution of SNP marker effects for faecal worm egg count in sheep, and the feasibility of using these markers to predict genetic merit for resistance to worm infections

Quantitative trait loci for internal nematode resistance in sheep: a review

Indirect DNA/gene diagnoses via electrophoresis – an obsolete principle?

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