An overview on the role of plant-derived tannins for the treatment of lung cancer

Rajasekar, N.; Sivanantham, Ayyanar; Ravikumar, Vasulinga T.; Rajasekaran, Subbiah

doi:10.1016/j.phytochem.2021.112799

Cited by 26 publications

(12 citation statements)

References 88 publications

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“…A type of condensed tannin, catechin, was reported in several documents as a constituent of P. odoratum ( Nanasombat and Teckchuen, 2009 ; Woraratphoka et al, 2012 ; Pawłowska et al, 2020 ; Kawvised et al, 2021 ) as well as its metabolite, gallic acid ( Ahongshangbam et al, 2014 ; Kawvised et al, 2021 ). In a review by Rajasekar et al, it was found that tannins exhibited essential roles in the treatment of lung cancer through the induction of apoptosis and cell cycle arrest, attenuation of epithelial-to-mesenchymal transition, and regulation of tumor cell migration, invasiveness, and angiogenesis ( Rajasekar et al, 2021 ). Many studies have revealed that tannins can enhance the anticancer effects of hormonal and chemotherapy medications, such as tamoxifen and doxorubicin ( Tikoo et al, 2011 ; AlMalki et al, 2021 ; Youness et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

“…Among these compounds, alkaloids are very well known as anticancer agents. Furthermore, some of the rest compounds were reported about anticancer activities, for example, rutin, quercetin, and some of their biotransformed metabolites ( Cipák et al, 2003 ; Araújo et al, 2013 ), tannins ( Rajasekar et al, 2021 ; Tikoo et al, 2011 ; AlMalki et al, 2021 ; Youness et al, 2021 ), saponins ( Elekofahinti et al, 2021 ), and quinones ( Kuete et al, 2016 ; Shen et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

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Anticancer Activities of Polygonum odoratum Lour.: A Systematic Review

et al. 2022

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Cancers are a potential cause of death worldwide and represent a massive burden for healthcare systems. Treating cancers requires substantial resources, including skilled personnel, medications, instruments, and funds. Thus, developing cancer prevention and treatment measures is necessary for healthcare personnel and patients alike. P. odoratum (Polygonaceae family) is a plant used as a culinary ingredient. It exhibits several pharmacological activities, such as antibacterial, antifungal, antioxidant, anti-inflammatory, and anticancer. Several classes of phytochemical constituents of P. odoratum have been reported. The important ones might be polyphenol and flavonoid derivatives. In this systematic review, the activities of P. odoratum against cancerous cells were determined and summarized. Data were obtained through a systematic search of electronic databases (EMBASE, PubMed, Scopus, Thai Thesis Database, Science Direct and Clinical Key). Eight studies met the eligibility criteria. The cancerous cell lines used in the studies were lymphoma, leukemia, oral, lung, breast, colon, and liver cancer cells. Based on this review, P. odoratum extracts significantly affected Epstein-Barr virus (EBV) genome-carrying human lymphoblastoid (Raji), mouse lymphocytic leukemia (P388), human acute lymphocytic leukemia (Jurkat), breast adenocarcinoma (MCF-7), human colon adenocarcinoma (HT-29), human T lymphoblast (MOLT-4), human promyelocytic leukemia cell line (HL-60), human hepatocellular carcinoma (HepG2), and oral squamous cell carcinoma (SAS, SCC-9, HSC-3) through induction of cell apoptosis, arrest of the cell cycle, inhibition of cell proliferation, migration, and colonization. The molecular mechanism of P. odoratum against cancers was reported to involve suppressing essential proteins required for cell proliferation, colonization, migration, apoptosis, and angiogenesis. They were survivin, cyclin-D, cyclooxygenase 2 (COX-2), matrix metalloproteinase-9 (MMP-9), and vascular endothelial growth factor A (VEGF-A). The extract of P. odoratum was also involved in the protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway by inhibiting the expression of Akt, phosphorylated Akt, mTOR, and phosphorylated mTOR. From the key results of this review, P. odoratum is a promising chemotherapy and chemopreventive agent. Further investigation of its pharmacological activity and mechanism of action should be conducted using standardized extracts. In vivo experiments and clinical trials are required to confirm the anticancer activity.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anticancer Activities of Polygonum odoratum Lour.: A Systematic Review

et al. 2022

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“…Later, it was shown [81] that tannin fractions derived from betel nut were genotoxic and caused chromatid breaks in mouse bone marrow cells. However, evidence has mounted that tannic acid, a specific form of tannin, possesses chemopreventive properties with possible uses in cancer prevention and as an adjuvant in cancer treatment [82]. Consistent with this view, tannic acid induces apoptosis, causes cell cycle arrest and limits the proliferation of cancer cells in animal models [83].…”

Section: Tanninsmentioning

confidence: 97%

Molecular Mechanisms of Malignant Transformation of Oral Submucous Fibrosis by Different Betel Quid Constituents—Does Fibroblast Senescence Play a Role?

Zhang

Chua

Dang

et al. 2022

IJMS

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Betel quid (BQ) is a package of mixed constituents that is chewed by more than 600 million people worldwide, particularly in Asia. The formulation of BQ depends on a variety of factors but typically includes areca nut, betel leaf, and slaked lime and may or may not contain tobacco. BQ chewing is strongly associated with the development of potentially malignant and malignant diseases of the mouth such as oral submucous fibrosis (OSMF) and oral squamous cell carcinoma (OSCC), respectively. We have shown recently that the constituents of BQ vary geographically and that the capacity to induce disease reflects the distinct chemical composition of the BQ. In this review, we examined the diverse chemical constituents of BQ and their putative role in oral carcinogenesis. Four major areca alkaloids—arecoline, arecaidine, guvacoline and guvacine—together with the polyphenols, were identified as being potentially involved in oral carcinogenesis. Further, we propose that fibroblast senescence, which is induced by certain BQ components, may be a key driver of tumour progression in OSMF and OSCC. Our study emphasizes that the characterization of the detrimental or protective effects of specific BQ ingredients may facilitate the development of targeted BQ formulations to prevent and/or treat potentially malignant oral disorders and oral cancer in BQ users.

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“…[44,45] The mechanism that TA inhibited inflammation was proved through desta-bilizing the COX-2 messenger RNA (mRNA). [46] Thus, we first analyzed the COX-2 expression in tumors by immunofluorescence staining. As shown in Figure 4B and Figure S6 (Supporting Information), the expression of COX-2 was significantly reduced in iSGels-and iSGels@aOX40-treated groups compared to the control and aOX40-treated groups.…”

Section: Immunoassay In Tumor and Spleens After Various Treatmentsmentioning

confidence: 99%

In–Situ‐Sprayed Dual‐Functional Immunotherapeutic Gel for Colorectal Cancer Postsurgical Treatment

et al. 2021

Adv Healthcare Materials

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Surgery remains the most preferred treatment options for colorectal cancer (CRC). Paradoxically, local recurrence and distant metastasis are usually accelerated postsurgery as a consequence of local and systemic immunosuppression caused by surgery. Therefore, modulating tumor postoperative immune microenvironment and activating systemic antitumor immunity are necessary supplementaries for CRC therapy. Here, an in-situ-sprayed immunotherapeutic gel loaded with anti-OX40 antibody (iSGels@aOX40) is reported for CRC postsurgical treatment. The iSGel is formed instantly after spraying with strong adhesion ability via crosslinking between tannic acid (TA) and poly(l-glutamic acid)-g-methoxy poly(ethylene glycol)/phenyl boronic acid (PLG-g-mPEG/PBA). TA not only serves as one component of the iSGel but also relieves the postsurgical immunosuppressive microenvironment by inhibiting the activity of cyclo-oxygenase-2 (COX-2). The aOX40 serves as an immune agonistic antibody and is released from the iSGel in a constant manner lasting for over 20 days. In a subcutaneous murine CRC model, the iSGels@aOX40 results in complete inhibition on tumor recurrence. In addition, the cured mice show resistance to tumor re-challenge, suggesting that immune memory effects are established after the iSGels@aOX40 treatment. In an orthotopic CRC peritoneal metastatic model, the iSGels@aOX40 also remarkably inhibits the growth of the abdominal metastatic tumors, suggesting great potential for clinical CRC therapy.

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An overview on the role of plant-derived tannins for the treatment of lung cancer

Cited by 26 publications

References 88 publications

Anticancer Activities of Polygonum odoratum Lour.: A Systematic Review

Anticancer Activities of Polygonum odoratum Lour.: A Systematic Review

Molecular Mechanisms of Malignant Transformation of Oral Submucous Fibrosis by Different Betel Quid Constituents—Does Fibroblast Senescence Play a Role?

In–Situ‐Sprayed Dual‐Functional Immunotherapeutic Gel for Colorectal Cancer Postsurgical Treatment

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