An Overview on the Recent Technologies and Advances in Drug Delivery of Poorly Water-Soluble Drugs

Abstract

Solubility can be defined as the amount of solute dissolved in a solvent at certain conditions to yield a single-phase system. Solubility of active pharmaceutical ingredients is considered the main parameter to get the most desired drug concentration in general circulation
 in order to achieve the desired therapeutic effect. Poor aqueous solubility considered the main problem occurs in the formulation progress of new chemical entities; in addition to the standard improvement; solubility is the main dispute for formulation scientists. The drug must appear as solution at the site of absorption in order to be absorbed. Many physical or chemical modification techniques are used to improve the solubility of low aqueous soluble drugs, in addition to other techniques such as particle size reduction, crystal engineering, salt formation, solid dispersion, use of surfactant and complexation. The selection of the solubility improvement methods depends on drug characteristics, location of absorption and the features of the administered dosage form.

Topical Nanoemulsion-Based Gel of Isoconazole Nitrate

“…The measured pH values of NEs were suitable for topical application due to comparable values with the skin pH, which ranges from 4.5 to 6.5 and therefore evade skin irritation and/or sensitivity [43]. The results of T% demonstrate that the produced NEs were transparent and clear, and Table (4) shown NEs' transparency. The ISN NE with the highest T% was NE14 (98.8%).…”

“…Numerous studies have highlighted the pharmaceutical importance of nanotechnology as vehicles for dermal and transdermal delivery of a wide variety of drugs, since the physic-chemical properties of skin make difficult to some drugs penetration through the skin [3]. An advanced drug delivery technology, nanoemulsions are being evaluated for their potential to solve the problem of delivering such as drugs, biological active agents, and genetic materials that are problematic to their release [4] [5]. Oil has been emulsified in the appropriate ratio in aqueous phase surfactant and co surfactant to form a colloidal dispersion is called a nanoemulsion (NE).…”