An overview on the interplay between nutraceuticals and gut microbiota

Cătinean, Adrian; Neag, Maria Adriana; Muntean, Dana; Bocşan, Ioana Corina; Buzoianu, Anca Dana

doi:10.7717/peerj.4465

Cited by 33 publications

(22 citation statements)

References 121 publications

(106 reference statements)

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“…Res, Bat, and Thu reached lower ratios (61 ± 23, 49 ± 22, 96 ± 53 respectively) than the control at 24 h (121 ± 73). Interestingly, Pino showed an increase (227 ± 127), while Pic stayed approximately equal (131 ± 98) to the control at 24 h. The response is a result of a decrease in the relative abundance of Firmicutes and an increase of Bacteroidetes, which is consistent with findings from other studies [2,7,27]. For Firmicutes, after treatment with all tested stilbenoids, the relative abundance decrease (−2.9% ± 0.03%) was lower than the control at 24 h (−4.6% ± 0.03%), with the least decrease observed under Oxy and Pino (−1.5% ± 0.03% and −0.7% ± 0.02%, respectively).…”

Section: Resultssupporting

confidence: 91%

Effect of Selected Stilbenoids on Human Fecal Microbiota

et al. 2019

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Dietary phenolics or polyphenols are mostly metabolized by the human gut microbiota. These metabolites appear to confer the beneficial health effects attributed to phenolics. Microbial composition affects the type of metabolites produced. Reciprocally, phenolics modulate microbial composition. Understanding this relationship could be used to positively impact health by phenolic supplementation and thus create favorable colonic conditions. This study explored the effect of six stilbenoids (batatasin III, oxyresveratrol, piceatannol, pinostilbene, resveratrol, thunalbene) on the gut microbiota composition. Stilbenoids were anaerobically fermented with fecal bacteria from four donors, samples were collected at 0 and 24 h, and effects on the microbiota were assessed by 16S rRNA gene sequencing. Statistical tests identified affected microbes at three taxonomic levels. Observed microbial composition modulation by stilbenoids included a decrease in the Firmicutes to Bacteroidetes ratio, a decrease in the relative abundance of strains from the genus Clostridium, and effects on the family Lachnospiraceae. A frequently observed effect was a further decrease of the relative abundance when compared to the control. An opposite effect to the control was observed for Faecalibacterium prausnitzii, whose relative abundance increased. Observed effects were more frequently attributed to resveratrol and piceatannol, followed by thunalbene and batatasin III.

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Section: Resultssupporting

confidence: 91%

Effect of Selected Stilbenoids on Human Fecal Microbiota

et al. 2019

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“…On the one hand, dietary and lifestyle interventions ( e.g. probiotics, prebiotics, other nutraceutical compounds) can directly modulate the composition and the functionality of microbiota [35,36,37,38]. Other approaches involve a genetic manipulation of microbiota itself [36,39,40].…”

Section: Holobionts Faecal Transplantation and Bacteriotherapymentioning

confidence: 99%

I’ve Gut A Feeling: Microbiota Impacting the Conceptual and Experimental Perspectives of Personalized Medicine

Amedei

Boem

2018

IJMS

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In recent years, the human microbiota has gained increasing relevance both in research and clinical fields. Increasing studies seem to suggest the centrality of the microbiota and its composition both in the development and maintenance of what we call “health” and in generating and/or favoring (those cases in which the microbiota’s complex relational architecture is dysregulated) the onset of pathological conditions. The complex relationships between the microbiota and human beings, which invest core notions of biomedicine such as “health” and “individual,” do concern not only problems of an empirical nature but seem to require the need to adopt new concepts and new perspectives in order to be properly analysed and utilized, especially for their therapeutic implementation. In this contribution we report and discuss some of the theoretical proposals and innovations (from the ecological component to the notion of polygenomic organism) aimed at producing this change of perspective. In conclusion, we summarily analyze what impact and what new challenges these new approaches might have on personalized/person centred/precision medicine.

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“…Particular problems occur when food-ingested bacteria growth remains unchecked (48). Then, probiotics seem to play an important role in keeping in control these pathogenic bacteria that could cause disease.…”

Section: Discussionmentioning

confidence: 99%

Functions of the Human Intestinal Microbiota in Relation to Functional Foods

Stavropoulou¹,

Tsigalou²,

Bezirtzoglou³

2018

Erciyes Med J

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Interest in functional foods has increased due to their relationship to diet and health. A healthy nutrition preserves the intestinal ecosystem and enhances health. Probiotic Lactobacillus appears to be highly sensitive to diet, environmental factors, stress, and antibiotics. Functional foods are known to play an important role in the stability of a human intestinal ecosystem. Moreover, dissemination of antibiotic resistances into consumed dairy and meat products could select some bacterial species. However, awareness of the relationship between food and health must be constant through permanent surveillance systems. The European Union guidelines should be imposed for the safe use of functional foods as foods or either as biotherapeutic agents. Functional foods are foods that surpass classic nutritional habits and have usually beneficial action for their host. They are classified into three main classes: probiotics, prebiotics, and symbiotics. The use of genetically modified probiotics could provide further chances for the industrial and pharmaceutical exploitation of probiotic microorganisms. In contrast, prebiotics are not microorganisms but non-digestible components. They stimulate the growth and/or the activity of several bacteria in a beneficial way. Their action contributes to a healthy and balanced intestinal microbiota. Systematic administration of prebiotics decreases blood lipid counts, as well as blood pressure, but increases the synthesis and absorption of foods and maybe has an anticarcinogenic action. They are also used extensively in the food industry. Last but not the least is the class of symbiotics, which combines a mixture of probiotics and prebiotics with both effects.

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An overview on the interplay between nutraceuticals and gut microbiota

Cited by 33 publications

References 121 publications

Effect of Selected Stilbenoids on Human Fecal Microbiota

Effect of Selected Stilbenoids on Human Fecal Microbiota

I’ve Gut A Feeling: Microbiota Impacting the Conceptual and Experimental Perspectives of Personalized Medicine

Functions of the Human Intestinal Microbiota in Relation to Functional Foods

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