An overview on recent biomedical applications of biopolymers: Their role in drug delivery systems and comparison of major systems

Syed, Murtaza; Zahari, Mior Ahmad Khushairi Mohd; Khan, Md. Maksudur Rahman; Beg, Mohammad Dalour Hossen; Abdullah, Norhayati

doi:10.1016/j.jddst.2022.104121

Cited by 22 publications

(12 citation statements)

References 208 publications

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“…Biopolymers are being widely used because of their lower impact in terms of pollution, which is because they Molecules 2023, 28, 3689 2 of 14 are obtained from natural resources or by-products. These materials are biodegradable, biocompatible, environmentally friendly, and widely available; they are associated with low production costs; and they have inherent antimicrobial potential [4].…”

Section: Introductionmentioning

confidence: 99%

Alginate–Chitosan Membranes for the Encapsulation of Lavender Essential Oil and Development of Biomedical Applications Related to Wound Healing

et al. 2023

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Biopolymers such as chitosan (CHT) or alginate (ALG) are among the most prominent for health-related applications due to their broad bioactivity. Their combination for the preparation of membranes is hereby proposed as an application for wound healing with the incorporation of lavender essential oil (LEO), widely known for its antioxidant and antimicrobial properties. The preparation of CHT, CHT + LEO, ALG, ALG + LEO, and CHT/ALG + LEO membranes was accomplished, and its composition was analyzed using Fourier Transform Infrared Spectroscopy (FTIR). The water absorption capacity and oil release profile of the membranes revealed higher water uptake capacity when a lower LEO release was obtained. The combined CHT/ALG + LEO film showed a water uptake percentage of 638% after 48 h and a maximum LEO release concentration of 42 mg/L. Cytotoxicity and biocompatibility of the prepared membranes were studied using a HaCaT cell line, with an assessment of cell viability regarding film leachables, DNA quantification, and DAPI-phalloidin staining. The results revealed that the indirect contact of the prepared membranes via its leachables does not compromise cell viability, and upon direct contact, cells do not adhere or proliferate on the surface of the membranes. Moreover, the CHT/ALG + LEO membrane increases cell proliferation, making it suitable for applications in wound healing.

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Section: Introductionmentioning

confidence: 99%

Alginate–Chitosan Membranes for the Encapsulation of Lavender Essential Oil and Development of Biomedical Applications Related to Wound Healing

et al. 2023

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“…FDM and IJP are the most preferred 3D printing techniques used in pharmaceutics and drug delivery applications. These techniques provide high accuracy, patient-customized drugs, quick drug release, and high dosage loading of drugs [419] . However, they suffer from low productivity, compared to conventional fabrication techniques of biomedicine.…”

Section: Scopes Of Biopolymeric Composites In Healthcare Systemmentioning

confidence: 99%

Additive manufacturing of sustainable biomaterials for biomedical applications

Arif

Khalid

Noroozi

et al. 2023

Asian Journal of Pharmaceutical Sciences

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“…The versatile nature of synthetic polymers has led to their widespread use across diverse fields . In contemporary applications, synthetic polymers play a pivotal role exemplifying the revolutionary impact of polymer advancements . Derived from natural sources, biopolymers are eco-friendly and sustainable, requiring fewer resources than petrochemical-based polymers. , Widely used in industries such as food packaging, agriculture, and medicine, common biopolymers include cellulose, starch, proteins, and polyhydroxybutyrate (PHB), aligning with the increasing demand for sustainable alternatives. , …”

Section: Introductionmentioning

confidence: 99%

Selective Extraction and Quantification of Hemoglobin Based on a Novel Molecularly Imprinted Nanopolymeric Structure of Poly(acrylamide-vinyl imidazole)

Şarkaya,

Özçelik,

Yaşar

et al. 2024

ACS Omega

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Imbalances in hemoglobin (Hb) levels can lead to conditions such as anemia or polycythemia, emphasizing the importance of precise Hb extraction from blood. To address this, a novel synthetic imprinted polymer was meticulously developed for capturing and separating Hb. Poly(acrylamide-vinylimidazole) nanopolymer (poly(AAm-VIM)) was synthesized using acrylamide and vinyl imidazole as functional monomers through surfactant-free emulsion polymerization. Characterization using FTIR, particle size, zeta potential, and SEM ensured the polymer's structure. The Hb-imprinted nanopolymer (Hbpoly(AAm-VIM)) demonstrated notable specificity, with a calculated Hb-specific adsorption value (Q max ) of 3.7377 mg/g in a medium containing 2.5 mg/mL Hb. The molecularly imprinted polymer (MIP) exhibited approximately 5 times higher Hb adsorption than the nonimprinted polymer (NIP). Under the same conditions, the imprinted nanopolymer displayed 2.39 and 2.17 times greater selectivity for Hb over competing proteins such as bovine serum albumin (BSA) and lysozyme (Lys), respectively. Also, SDS-PAGE analysis results confirmed the purification of Hb by the molecularly imprinted nanopolymer. These results underscore the heightened specificity and efficacy of the molecularly imprinted nanopolymer in selectively targeting Hb atoms among other proteins. Incorporating such polymers is justified by their notable affinity, cost-effectiveness, and facile production. This research contributes valuable insights into optimizing synthetic imprinted polymers for efficient Hb extraction, with potential in medical diagnostics and treatment applications.

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An overview on recent biomedical applications of biopolymers: Their role in drug delivery systems and comparison of major systems

Cited by 22 publications

References 208 publications

Alginate–Chitosan Membranes for the Encapsulation of Lavender Essential Oil and Development of Biomedical Applications Related to Wound Healing

Alginate–Chitosan Membranes for the Encapsulation of Lavender Essential Oil and Development of Biomedical Applications Related to Wound Healing

Additive manufacturing of sustainable biomaterials for biomedical applications

Selective Extraction and Quantification of Hemoglobin Based on a Novel Molecularly Imprinted Nanopolymeric Structure of Poly(acrylamide-vinyl imidazole)

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