An Overview on Plant Derived Phenolic Compounds and Their Role in Treatment and Management of Diabetes

Abstract

Objectives In recent decades, the trend for treating diabetes mellitus (DM) has shifted toward alternative medicines that are obtained from plant sources. Existing literature suggests that phenolic compounds derived from plants possess promising health-promoting properties. This study aimed to discuss the role of plant-derived phenolic compounds in the effective treatment and management of diabetes. Methods Information about plant secondary metabolites, phenolic compounds, and their role in the treatment and management of diabetes was collected from different databases, such as Pubmed, ScienceDirect, Scopus, and Google Scholar. Keywords like secondary metabolites, phenolic compounds, simple phenol, flavonoids, lignans, stilbenes, and diabetes were searched. Research and review articles with relevant information were included in the study. Results Anti-diabetic studies of the four major classes of phenolic compounds were included in this review. The plant-derived phenolic compounds were reported to have potent anti-diabetic activities. However, each class of phenolic compounds was found to behave differently according to various mechanisms. Conclusion The obtained results suggest that phenolic compounds derived from natural sources display promising anti-diabetic activities. Based on the available information, it can be concluded that phenolic compounds obtained from various natural sources play key roles in the treatment and management of diabetes.

Identification of antidiabetic inhibitors from Allophylus villosus and Mycetia sinensis by targeting α-glucosidase and PPAR-γ: In-vitro, in-vivo, and computational evidence

“…Additionally, n-hexane fractions surpassed ethyl acetate fractions in M. sinensis and A. villosus for flavonoid contents. Both, Phenolic and flavonoid compounds are capable in glucose homeostasis mechanism ( Al-Ishaq et al, 2019 , Deka et al, 2022 ) as well as performed inhibitory activities on alpha glucosidase and PPAR-γ ( Proença et al, 2017 , Salam et al, 2008 , Swargiary et al, 2023 ).…”

The gut-liver axis in fatty liver disease: role played by natural products

“…Phenols are mainly produced by plants through various metabolic pathways including phenols/phenolic acids, flavonoids, stilbenes and lignans ( Deka et al, 2022 ).…”

Exploring Folklore Ecuadorian Medicinal Plants and Their Bioactive Components Focusing on Antidiabetic Potential: An Overview

“…Similarly, plant-derived phenols are bioactive compounds that possess immense antidiabetic activity through various mechanisms such as AMPK pathway activation, α glucosidase or α amylase inhibition, glucose regulation, insulin sensitivity improvement, and PPAR activation [93]. Chlorogenic acid, caffeic acid, coumaric acid, ellagic acid, ferulic acid, and vanillic acid are the natural phenols found in many Ecuadorian plants such as Ilex guayusa [89], Pelargonium graveolens [91], Persea americana [31,94], Verbena litoralis [92], and Artocarpus altilis [95]. The antidiabetic activity of chlorogenic acid is attributed to an increase in the glucose uptake in L6 muscular cells and a rise in insulin secretion from the INS-1E insulin-secreting cell line and rat islets of Langerhans [96].…”