An overview on molecular imprinted polymers combined with surface-enhanced Raman spectroscopy chemical sensors toward analytical applications

Ma, Jun; Yan, Mengmeng; Feng, Gege; Ying, Ying; Chen, Ge; Shao, Yong; She, Yongxin; Wang, Miao; Sun, Jianchun; Zheng, Lirong; Wang, Jing; El‐Aty, A.M. Abd

doi:10.1016/j.talanta.2020.122031

Cited by 43 publications

(22 citation statements)

References 99 publications

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“…Besides, it is suitable for long-term monitoring ( Zhao et al, 2021a ; Lopez-Lorente, 2021 ). SERS technology is widely used in various biomedical fields, such as nucleic acid, protein, human cells, human tissues and human body fluids ( Calderon et al, 2021 ; Ma et al, 2021 ; Xi and Liang, 2021 ), and has important applications in the diagnosis of tumors ( Guerrini et al, 2021 ; Shen et al, 2021 ; Sun et al, 2021 ). Nowdays, it is believed that physical enhancement mechanism and chemical enhancement mechanism are two explanation mechanisms of SERS enhancement.…”

Section: Introductionmentioning

confidence: 99%

Advances in the Application of Exosomes Identification Using Surface-Enhanced Raman Spectroscopy for the Early Detection of Cancers

Yang

Jia

2022

Front. Bioeng. Biotechnol.

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Exosomes are small nanoscale vesicles with a double-layered lipid membrane structure secreted by cells, and almost all types of cells can secrete exosomes. Exosomes carry a variety of biologically active contents such as nucleic acids and proteins, and play an important role not only in intercellular information exchange and signal transduction, but also in various pathophysiological processes in the human body. Surface-enhanced Raman Spectroscopy (SERS) uses light to interact with nanostructured materials such as gold and silver to produce a strong surface plasmon resonance effect, which can significantly enhance the Raman signal of molecules adsorbed on the surface of nanostructures to obtain a rich fingerprint of the sample itself or Raman probe molecules with ultra-sensitivity. The unique advantages of SERS, such as non-invasive and high sensitivity, good selectivity, fast analysis speed, and low water interference, make it a promising technology for life science and clinical testing applications. In this paper, we briefly introduce exosomes and the current main detection methods. We also describe the basic principles of SERS and the progress of the application of unlabeled and labeled SERS in exosome detection. This paper also summarizes the value of SERS-based exosome assays for early tumor diagnosis.

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Section: Introductionmentioning

confidence: 99%

Advances in the Application of Exosomes Identification Using Surface-Enhanced Raman Spectroscopy for the Early Detection of Cancers

Yang

Jia

2022

Front. Bioeng. Biotechnol.

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“…Recently, review manuscripts have been published, describing imprinted polymers in combination with sensor devices that work based on a specific detection technique like electrochemical [102,103] or optical methods [104,105]. This review aims to provide an overview of the developed strategies for modification of sensor devices, that work based on different detection techniques (including optical, electrochemical, electromechanical and chemiresistive sensors), with MIPs (MIP particles or MIP thin layers were used either directly or in a nanocomposite) for a broad range of important chemicals with different physical-chemical properties.…”

Section: Introductionmentioning

confidence: 99%

Molecularly Imprinted Polymer-Based Sensors for Priority Pollutants

Zarejousheghani

Rahimi

Borsdorf

et al. 2021

Sensors

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Globally, there is growing concern about the health risks of water and air pollution. The U.S. Environmental Protection Agency (EPA) has developed a list of priority pollutants containing 129 different chemical compounds. All of these chemicals are of significant interest due to their serious health and safety issues. Permanent exposure to some concentrations of these chemicals can cause severe and irrecoverable health effects, which can be easily prevented by their early identification. Molecularly imprinted polymers (MIPs) offer great potential for selective adsorption of chemicals from water and air samples. These selective artificial bio(mimetic) receptors are promising candidates for modification of sensors, especially disposable sensors, due to their low-cost, long-term stability, ease of engineering, simplicity of production and their applicability for a wide range of targets. Herein, innovative strategies used to develop MIP-based sensors for EPA priority pollutants will be reviewed.

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“…Molecularly imprinted polymers (MIPs) are prepared using the target molecules as templates to produce receptor sites. After removing the template, the target molecules can be selectively captured [17][18][19][20][21]. Castro-Grijalba et al developed a SERS sensor through spin-coating MIP to form thin film for polycyclic aromatic hydrocarbons (PAHs) detection [22].…”

Section: Introductionmentioning

confidence: 99%

SERS Gas Sensors Based on Multiple Polymer Films with High Design Flexibility for Gas Recognition

Chen

Guo

Sassa

et al. 2021

Sensors

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The Surface-Enhanced Raman Scattering (SERS) technique is utilized to fabricate sensors for gas detection due to its rapid detection speed and high sensitivity. However, gases with similar molecular structures are difficult to directly discriminate using SERS gas sensors because there are characteristic peak overlaps in the Raman spectra. Here, we proposed a multiple SERS gas sensor matrix via a spin-coating functional polymer to enhance the gas recognition capability. Poly (acrylic acid) (PAA), Poly (methyl methacrylate) (PMMA) and Polydimethylsiloxane (PDMS) were employed to fabricate the polymer film. The high design flexibility of the two-layer film was realized by the layer-by-layer method with 2 one-layer films. The SERS gas sensor coated by different polymer films showed a distinct affinity to target gases. The principle component analysis (PCA) algorithm was used for the further clustering of gas molecules. Three target gases, phenethyl alcohol, acetophenone and anethole, were perfectly discriminated, as the characteristic variables in the response matrix constructed by the combination of gas responses obtained 3 one-layer and 3 two-layer film-coated sensors. This research provides a new SERS sensing approach for recognizing gases with similar molecular structures.

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An overview on molecular imprinted polymers combined with surface-enhanced Raman spectroscopy chemical sensors toward analytical applications

Cited by 43 publications

References 99 publications

Advances in the Application of Exosomes Identification Using Surface-Enhanced Raman Spectroscopy for the Early Detection of Cancers

Advances in the Application of Exosomes Identification Using Surface-Enhanced Raman Spectroscopy for the Early Detection of Cancers

Molecularly Imprinted Polymer-Based Sensors for Priority Pollutants

SERS Gas Sensors Based on Multiple Polymer Films with High Design Flexibility for Gas Recognition

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