An overview of two decades of diet restriction studies using Drosophila

Krittika, Sudhakar; Yadav, Pankaj

doi:10.1007/s10522-019-09827-0

Cited by 15 publications

(11 citation statements)

References 168 publications

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“…Caloric restriction (CR)-within limits-often leads to increased lifespan, while high calorie diets lead to accelerated aging. Indeed, CR is known to extend lifespan in a sex-specific and strain-specific manner, which is well documented in mice and fruit flies (reviewed in Garratt, 2020 andKrittika &Yadav, 2019). In some insects, CR results in smaller, longer-lived animals.…”

Section: Sexual Dimorphism In Body Sizementioning

confidence: 99%

Sex‐specific aging in animals: Perspective and future directions

et al. 2022

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Section: Sexual Dimorphism In Body Sizementioning

confidence: 99%

Sex‐specific aging in animals: Perspective and future directions

et al. 2022

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“…Dietary Restriction (DR) has long been established to extend lifespan in many species of animals, including mice, fruit flies, and nematodes ( McCay et al, 1935 ; Kapahi et al, 2017 ; Krittika and Yadav, 2019 ). This intervention has been of particular interest in the field of aging due in part to its highly conserved nature.…”

Section: Genetic Pathways That Influence Reproductive Agingmentioning

confidence: 99%

Reproductive Aging in Caenorhabditis elegans: From Molecules to Ecology

Scharf

Pohl

Egan

et al. 2021

Front. Cell Dev. Biol.

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Aging animals display a broad range of progressive degenerative changes, and one of the most fascinating is the decline of female reproductive function. In the model organism Caenorhabditis elegans, hermaphrodites reach a peak of progeny production on day 2 of adulthood and then display a rapid decline; progeny production typically ends by day 8 of adulthood. Since animals typically survive until day 15 of adulthood, there is a substantial post reproductive lifespan. Here we review the molecular and cellular changes that occur during reproductive aging, including reductions in stem cell number and activity, slowing meiotic progression, diminished Notch signaling, and deterioration of germ line and oocyte morphology. Several interventions have been identified that delay reproductive aging, including mutations, drugs and environmental factors such as temperature. The detailed description of reproductive aging coupled with interventions that delay this process have made C. elegans a leading model system to understand the mechanisms that drive reproductive aging. While reproductive aging has dramatic consequences for individual fertility, it also has consequences for the ecology of the population. Population dynamics are driven by birth and death, and reproductive aging is one important factor that influences birth rate. A variety of theories have been advanced to explain why reproductive aging occurs and how it has been sculpted during evolution. Here we summarize these theories and discuss the utility of C. elegans for testing mechanistic and evolutionary models of reproductive aging.

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“…We performed the project with the fruit fly Drosophila because it offers many advantages; besides the unchallenged wealth of genetic tools, it allows lifespan to be used as the most relevant read-out for both pharmacological and dietary interventions. The effects of DR and CR are well-established in Drosophila , especially the lifespan- and healthspan-prolonging effects [ 47 ]. Although the lifespan-extending effects of protein restriction are not fully understood, effects on insulin signaling [ 48 ] and TOR signaling [ 47 ] might not only explain these effects, but also the beneficial effects on tumor growth.…”

Section: Discussionmentioning

confidence: 99%

“…The effects of DR and CR are well-established in Drosophila , especially the lifespan- and healthspan-prolonging effects [ 47 ]. Although the lifespan-extending effects of protein restriction are not fully understood, effects on insulin signaling [ 48 ] and TOR signaling [ 47 ] might not only explain these effects, but also the beneficial effects on tumor growth. Our experiments confirmed that a protein-restricted diet prolongs lifespan.…”

Section: Discussionmentioning

confidence: 99%