An Overview of Toxicogenomics

Hamadeh, Hisham K.; Amin, Rupesh P.; Paules, Richard S.; Afshari, Cynthia A.

doi:10.21775/cimb.004.045

Cited by 37 publications

(6 citation statements)

References 77 publications

(72 reference statements)

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“…Information on the internal effect of pesticides on populations from different habitats may help to understand the climate effect observed in our study. This would require toxicogenomic (Hamadeh et al., 2002) studies analysing other ecotoxicological endpoints, such as the activity of detoxification enzymes (Zhou et al., 2019), the binding of active ingredients to target and non‐target receptors (Narahashi et al., 2007), and gene expression (Giambò et al., 2021).…”

Section: Discussionmentioning

confidence: 99%

Which temperature matters? Effects of origin, rearing and test conditions on the chemical sensitivity of Pardosa amentata

Duque,

Schäfer,

Entling

2023

J Applied Entomology

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Spiders may be adversely affected by pesticides, yet they are not included in regulatory risk assessment and a related standard guideline to test their sensitivity to chemicals is lacking. Different laboratory setups, including test temperature and relative humidity, have been shown to influence the sensitivity of spiders. The climate from which spiders originate and the rearing conditions in the laboratory prior to ecotoxicological testing may also alter their sensitivity to chemicals, potentially in interaction with test conditions. We investigated the influence of population origin, rearing and test temperature on the chemical sensitivity of the spider Pardosa amentata towards lambda‐cyhalothrin. We collected female P. amentata carrying egg sacs from two climates, i.e., boreal and cool temperate. Spiders were kept in the laboratory and their offspring were reared and tested at 15, 20 and 25°C. Hatching of egg sacs largely failed at 15°C, while a moderate spiderling mortality (40%) was recorded at 20°C. At 25°C, mortality increased (63%) and a faster developmental rate was observed. Rearing and test temperature had no significant effects on spider chemical sensitivity. However, spider chemical sensitivity differed between populations, with spiders from boreal climate being 38% more sensitive than spiders from cool temperate climate. A higher sensitivity towards lambda‐cyhalothrin increases the risk of population reduction in treated areas, with potential alterations of ecosystem functions such as biological control. Our results suggest that the climatic origin of test organisms deserves stronger attention in ecotoxicological research.

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Section: Discussionmentioning

confidence: 99%

Which temperature matters? Effects of origin, rearing and test conditions on the chemical sensitivity of Pardosa amentata

Duque,

Schäfer,

Entling

2023

J Applied Entomology

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“…Gene-environment interactions are postulated as triggers for different diseases in susceptible individuals. Due to the importance of these interactions, toxicogenomics has emerged, which allows the interpretation of the activity of genes and proteins in response to toxic substances [19,20]. To explore the interaction between hub genes and available drugs, a network was constructed using CTD and visualized by Cytoscape.…”

Section: Hub Gene-drug Interaction Network Analysismentioning

confidence: 99%

lncRNA-mRNA Co-Expression and Regulation Analysis in Lung Fibroblasts from Idiopathic Pulmonary Fibrosis

López-Martínez,

Santos-Álvarez,

Velázquez-Enríquez

et al. 2024

ncRNA

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Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease marked by abnormal accumulation of extracellular matrix (ECM) due to dysregulated expression of various RNAs in pulmonary fibroblasts. This study utilized RNA-seq data meta-analysis to explore the regulatory network of hub long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) in IPF fibroblasts. The meta-analysis unveiled 584 differentially expressed mRNAs (DEmRNA) and 75 differentially expressed lncRNAs (DElncRNA) in lung fibroblasts from IPF. Among these, BCL6, EFNB1, EPHB2, FOXO1, FOXO3, GNAI1, IRF4, PIK3R1, and RXRA were identified as hub mRNAs, while AC008708.1, AC091806.1, AL442071.1, FAM111A-DT, and LINC01989 were designated as hub lncRNAs. Functional characterization revealed involvement in TGF-β, PI3K, FOXO, and MAPK signaling pathways. Additionally, this study identified regulatory interactions between sequences of hub mRNAs and lncRNAs. In summary, the findings suggest that AC008708.1, AC091806.1, FAM111A-DT, LINC01989, and AL442071.1 lncRNAs can regulate BCL6, EFNB1, EPHB2, FOXO1, FOXO3, GNAI1, IRF4, PIK3R1, and RXRA mRNAs in fibroblasts bearing IPF and contribute to fibrosis by modulating crucial signaling pathways such as FoxO signaling, chemical carcinogenesis, longevity regulatory pathways, non-small cell lung cancer, and AMPK signaling pathways.

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“…The variable data derived from the transcriptomics, proteomics, and traditional toxicological data evaluation integrate into toxicogenomics and it helps to form a relationship between toxicological outcome and molecular genetics. 7 The toxicogenomics study is beginning to incorporate various studies of data streams like proteomics, transcriptomics and metabonomic. It is rapidly developing from the studies that are done on individual chemicals to knowledge and informatic-based science.…”

Section: Inclusion Of In-vitro Studymentioning

confidence: 99%

Recent Developments in Toxicology Study

Jana,

Chakravarty

2023

Asian J Pharm Res Dev

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The story of toxicology began in the primitive age where our ancestors were fighting the battle of survival, they recognized the poisonous plants and extracted the poison which they used to survive. That was just the beginning and by the 1500BC people already marked opium, hemlock and some certain metals as the dangerous poisonous substances. Toxicology was at first developed as the study of poisons but through the development it is now the study of adverse effect of chemical agents on living organism. The key of any development is to overcome the setbacks and the toxicological development was no exception. Various setbacks appeared through the ages like sulfanilamide catastrophe, irrational use of animals in toxicity study, cross species differences, financial exposures etc. All of these setbacks pushed the human beings to the urge of developing new methodology, technology for the toxicology study and as results various in-vitro study methods, toxicogenomics, toxicoproteomics study emerged.

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An Overview of Toxicogenomics

Cited by 37 publications

References 77 publications

Which temperature matters? Effects of origin, rearing and test conditions on the chemical sensitivity of Pardosa amentata

Which temperature matters? Effects of origin, rearing and test conditions on the chemical sensitivity of Pardosa amentata

lncRNA-mRNA Co-Expression and Regulation Analysis in Lung Fibroblasts from Idiopathic Pulmonary Fibrosis

Recent Developments in Toxicology Study

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