An Overview of Topical Antibiotics for Acne Treatment

Toyoda, Masahiko; Morohashi, Masaaki

doi:10.1159/000017846

Cited by 76 publications

(37 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…9,10 The adverse effects of topical antiacne agents include burning, erythema, scaling, flare-up, photosensitivity, and bacterial resistance. 4 Tretinoin (TRA) and BPO are used individually and in a cyclic manner for acne treatment.…”

mentioning

confidence: 99%

Formulation and evaluation of a topical niosomal gel containing a combination of benzoyl peroxide and tretinoin for antiacne activity

Gupta

Singh

Kotla

et al. 2014

IJN

View full text Add to dashboard Cite

A skin disease, like acne, is very common and normally happens to everyone at least once in their lifetime. The structure of the stratum corneum is often compared with a brick wall, with corneocytes surrounded by the mortar of the intercellular lipid lamellae. One of the best options for successful drug delivery to the affected area of skin is the use of elastic vesicles (niosomes) which can be transported through the skin through channel-like structures. In this study, a combination of tretinoin (keratolytic agent) and benzoyl peroxide (BPO) (a potent antibacterial) was given by using niosomes as promising carriers for the effective treatment of acne by acting on a pathogenic site. In this section, niosomal gel formulation encapsulated drugs have been evaluated for in vitro, ex vivo, and in vivo, for their predetermined characteristics; and finally the stability of the niosome gel was tested at different temperature conditions for understanding of the storage conditions required for maintaining the quality of formulation attributes. The prepared niosome was found to be in the range of 531 nm with a zeta potential of −43 mV; the entrapment efficiencies of tretinoin (TRA) and BPO niosomes were found to be 96.25%±0.56% and 98.75%±1.25%, respectively. The permeated amount of TRA and BPO from the niosomal gel after 24 hours was calculated as 6.25±0.14 μg/cm 2 and 5.04±0.014 μg/cm 2 , respectively. A comparative drug retention study in Wistar rat skin using cream, an alcoholic solution, and a niosomal gel showed 11.54 μg, 2.68 μg, and 15.54 μg amounts of TRA and 68.85 μg, 59.98 μg, and 143.78 μg amounts of BPO were retained in the layers of skin, respectively. In vivo studies of the niosomal gel and antiacne cream of TRA and BPO showed that the niosomal gel was more efficacious than the antiacne cream because niosomal gels with a 4.16-fold lower dose of BPO provided the same therapeutic index at targeted sites in comparison to the antiacne cream.

show abstract

mentioning

confidence: 99%

Formulation and evaluation of a topical niosomal gel containing a combination of benzoyl peroxide and tretinoin for antiacne activity

Gupta

Singh

Kotla

et al. 2014

IJN

View full text Add to dashboard Cite

show abstract

“…Having shown favorable clinical effects on acne in most clinical trials, antibiotics, above all erythromycin, clindamycin and tetracyclines, have become an integral part of both topical and systemic acne therapy [1]. As discussed above, propionibacteria have increasingly developed resistances to these antibiotics in recent decades, especially to erythromycin and clindamycin.…”

Section: Discussionmentioning

confidence: 99%

“…This role appears to relate essentially to the conversion of microcomedones into the inflammatory efflorescences of acne. This hypothesis is strongly supported by the fact that most studies have shown that antibiotics reduce mainly the inflammatory efflorescences of acne, while only a few studies have also suggested an effect on comedone counts [1]. Morphologically and immunohistochemically, the inflammatory reaction consists of an accumulation of CD4+ T cells [2].…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Lipase Activity in Antibiotic-Resistant <i>Propionibacterium acnes</i> Strains

Gloor

Wasik²,

Becker³

et al. 2002

Dermatology

View full text Add to dashboard Cite

Background and Objective: Erythromycin-sensitive and/or clindamycin-sensitive strains of Propionibacterium acnes show a reduced lipase production at levels below the minimal growth-inhibitory concentration (MIC). The objective of this study was to determine whether erythromycin and clindamycin concentrations far below the MIC inhibit lipase production in P. acnes strains resistant to these antibiotics. Methods: Of 42 P. acnes strains, 10 showed an MIC >256 µg/ml for erythromycin. Two strains showed MICs of 0.19 and 0.25 µg/ml, while the MIC of the remaining strains was ≤0.016 µg/ml. Lipase activity was determined up to a concentration of 192 µg/ml by cultivation on spirit blue agar + lipase reagent. The 10 strains whose erythromycin MIC was >256 µg/ml were also tested for lipase inhibition by clindamycin. While this method fails to differentiate between inhibition of lipase production and inhibition of lipase activity, the absence of inhibition of lipase activity rules out inhibition of lipase production. Results: Inhibition of lipolysis by sub-MIC concentrations was demonstrated only for clindamycin in 3 P. acnes strains. However, lipase inhibition was seen only at the dilution level immediately below the MIC. Conclusions: Resistant P. acnes strains with high erythromycin and/or clindamycin MICs can be ruled out to show in vitro inhibition of lipase production at antibiotic concentrations far below the MIC.

show abstract

“…Antimikro bielle Wirkungen betreffen die Suppressi on des Wachstums von P. acnes [27], nicht antimikrobielle, meist antiinflammato rische Wirkmechanismen betreffen die Hemmung der Lipaseproduktion durch P. acnes [28], die Hemmung der Leuko zytenchemotaxis [26] und die Neutralisa tion von Hydroxylradikalen [22].…”

Section: Wirkmechanismenunclassified

Management der Acne vulgaris: Fokus auf Clindamycin und Zink

Korting

Schöllmann

2008

Hautarzt

View full text Add to dashboard Cite

Topical antibiotics, especially clindamycin, are well-accepted in the treatment of mild to moderate acne. Combinations of clindamycin and other agents such as benzoyl peroxide, retinoids or zinc, are possibly superior to clindamycin monotherapy regarding efficacy and tolerability with the combination 1% clindamycin/5% benzoyl peroxide being particularly well-supported by evidence. Moreover, a recent study has shown that patients themselves prefer a complex of zinc acetate/clindamycin phosphate.

show abstract

An Overview of Topical Antibiotics for Acne Treatment

Cited by 76 publications

References 21 publications

Formulation and evaluation of a topical niosomal gel containing a combination of benzoyl peroxide and tretinoin for antiacne activity

Formulation and evaluation of a topical niosomal gel containing a combination of benzoyl peroxide and tretinoin for antiacne activity

Inhibition of Lipase Activity in Antibiotic-Resistant <i>Propionibacterium acnes</i> Strains

Management der Acne vulgaris: Fokus auf Clindamycin und Zink

Contact Info

Product

Resources

About