An overview of the two-component system GarR/GarS role on antibiotic production in Streptomyces coelicolor
Rodrigo Cruz-Bautista,
Augusto Zelarayan-Agüero,
Beatriz Ruiz-Villafán
et al.
Abstract:The Streptomyces genus comprises Gram-positive bacteria known to produce over two-thirds of the antibiotics used in medical practice. The biosynthesis of these secondary metabolites is highly regulated and influenced by a range of nutrients present in the growth medium. In Streptomyces coelicolor, glucose inhibits the production of actinorhodin (ACT) and undecylprodigiosin (RED) by a process known as carbon catabolite repression (CCR). However, the mechanism mediated by this carbon source still needs to be und… Show more
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