An overview of the treatment of cutaneous leishmaniasis

Garza-Tovar, Talissa F; Sacriste-Hernández, Marco I; Juárez-Durán, Eder Rodrigo; Arenas, Roberto

doi:10.12703/r/9-28

Cited by 33 publications

(25 citation statements)

References 65 publications

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“…Cryotherapy alone can be efficient, particularly in the case of a small number lesions (at least 4 measuring smaller than 4 cm). 7 , 8 Most of the previously reported or published cases of verrucous CL were treated systemically. 4 , 5 , 6 …”

Section: Discussionmentioning

confidence: 99%

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A case of a verrucous and pseudotumoral mass on the leg that resolved with cryotherapy

Rekik

Sellami

Amouri

et al. 2022

Clinical Case Reports

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Section: Discussionmentioning

confidence: 99%

“…The treatment of CL can be topical or systemic. Cryotherapy alone can be efficient, particularly in the case of a small number lesions (at least 4 measuring smaller than 4 cm) 7,8 4‐6 …”

Section: Discussionmentioning

confidence: 99%

A case of a verrucous and pseudotumoral mass on the leg that resolved with cryotherapy

Rekik

Sellami

Amouri

et al. 2022

Clinical Case Reports

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show abstract

“…FDA-approved lipid formulation of amphotericin B, AmBisome, is better tolerated than conventional amphotericin B but its high cost limits its use [30]. Local therapy such as thermotherapy (use of heat) and cryotherapy (application of subzero temperatures) have been used due to the thermosensitivity of the parasites [31]. Thermotherapy may be co-administered with infrared light, laser or direct electrical stimulation.…”

Section: Current Diagnosis and Treatment Options For Cutaneous Leishm...mentioning

confidence: 99%

Nanomedicine-based strategies to improve treatment of cutaneous leishmaniasis

et al. 2022

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Nanomedicine strategies were first adapted and successfully translated to clinical application for diseases, such as cancer and diabetes. These strategies would no doubt benefit unmet diseases needs as in the case of leishmaniasis. The latter causes skin sores in the cutaneous form and affects internal organs in the visceral form. Treatment of cutaneous leishmaniasis (CL) aims at accelerating wound healing, reducing scarring and cosmetic morbidity, preventing parasite transmission and relapse. Unfortunately, available treatments show only suboptimal effectiveness and none of them were designed specifically for this disease condition. Tissue regeneration using nano-based devices coupled with drug delivery are currently being used in clinic to address diabetic wounds. Thus, in this review, we analyse the current treatment options and attempt to critically analyse the use of nanomedicine-based strategies to address CL wounds in view of achieving scarless wound healing, targeting secondary bacterial infection and lowering drug toxicity.

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“…Gas lasers utilise gas as its laser medium, which in the specific context of anti-leishmanial treatment, either requires the use of carbon dioxide or argon. Solid-state lasers use ores as the laser medium, which in the context of anti-leishmanial treatment uses neodymium-doped yttrium aluminium garnet (Nd:YAG) or erbium ( 57 ).…”

Section: Current Treatmentsmentioning

confidence: 99%

Current and future strategies against cutaneous parasites

2022

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Cutaneous parasites are identified by their specific cutaneous symptoms which are elicited based on the parasite’s interactions with the host. Standard anti-parasitic treatments primarily focus on the use of specific drugs to disrupt the regular function of the target parasite. In cases where secondary infections are induced by the parasite itself, antibiotics may also be used in tandem with the primary treatment to deal with the infection. Whilst drug-based treatments are highly effective, the development of resistance by bacteria and parasites, is increasingly prevalent in the modern day, thus requiring the development of non-drug based anti-parasitic strategies. Cutaneous parasites vary significantly in terms of the non-systemic methods that are required to deal with them. The main factors that need to be considered are the specifically elicited cutaneous symptoms and the relative cutaneous depth in which the parasites typically reside in. Due to the various differences in their migratory nature, certain cutaneous strategies are only viable for specific parasites, which then leads to the idea of developing an all-encompassing anti-parasitic strategy that works specifically against cutaneous parasites. The main benefit of this would be the overall time saved in regards to the period that is needed for accurate diagnosis of parasite, coupled with the prescription and application of the appropriate treatment based on the diagnosis. This review will assess the currently identified cutaneous parasites, detailing their life cycles which will allow for the identification of certain areas that could be exploited for the facilitation of cutaneous anti-parasitic treatment.

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An overview of the treatment of cutaneous leishmaniasis

Cited by 33 publications

References 65 publications

A case of a verrucous and pseudotumoral mass on the leg that resolved with cryotherapy

A case of a verrucous and pseudotumoral mass on the leg that resolved with cryotherapy

Nanomedicine-based strategies to improve treatment of cutaneous leishmaniasis

Current and future strategies against cutaneous parasites

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