An overview of the prevalence of 25‐hydroxy-vitamin D inadequacy amongst elderly patients with or without fragility fracture in the United Kingdom

Dixon, Tracy; Mitchell, P. J.; Beringer, T. R. O.; Gallacher, S. J.; Moniz, C.; Patel, Sanjeev; Pearson, G; Ryan, P. J.

doi:10.1185/030079906x89810

Cited by 45 publications

(22 citation statements)

References 21 publications

(29 reference statements)

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“…The study subjects were in hospital at the time of recruitment for the following reasons: vascular disease [26], collapse or falls [15], rehabilitation following orthopedic surgery [10], infections [6], respiratory disease [3], and other problems [3]. Prior to hospital admission, 53 lived at home, seven in a retirement village, and three in residential care.…”

Section: Participantsmentioning

confidence: 99%

“…Vitamin D status is related to bone density [1][2][3][4][5], bone turnover markers [6,7], falls risk functional stability and strength [4,8], and to the occurrence of hip fractures [9][10][11]. Intervention studies with vitamin D suggest beneficial effects on fractures, particularly in institutionalized individuals and when calcium is co-administered [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

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High-dose oral vitamin D3 supplementation in the elderly

et al. 2008

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Section: Participantsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

High-dose oral vitamin D3 supplementation in the elderly

et al. 2008

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“…Since 1991, it has been recognized that the elderly are at high risk for vitamin D deficiency, particularly institutionalized elderly [4] and this concern continues today [5]. Recommendations for vitamin D in the current 1997 Dietary Reference Intakes (DRIs) reflect an age effect by having a higher recommendation for persons 50-70 years, for which the current recommendations are 400 and 600 IU for those over 70 years, compared with younger adults whose current DRI is 200 IU [6].…”

Section: Introductionmentioning

confidence: 99%

Correcting poor vitamin D status: Do older adults need higher repletion doses of vitamin D₃ than younger adults?

Whiting

Calvo

2010

Molecular Nutrition Food Res

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We conducted an examination of recent studies to determine whether older adults (>or=65 years) need higher levels of supplementary vitamin D than young adults when attempting to replete vitamin D status in deficient subjects, i.e. those with levels of 25-hydroxyvitamin D less than 75 nmol/L. As data on repletion with vitamin D(2) have recently been published, we restricted our discussion to the use of vitamin D(3) from dietary supplements, prescriptions for large oral doses, and bolus dosing or injections. Most published dosing regimens failed to achieve 75 nmol/L in most all subjects, whether young adults (<65 years) or older adults (>or=65 years). Whether as daily or bolus oral supplementation, elderly subjects appeared to need more vitamin D3 compared with younger adults, however, baseline levels, endpoints, study duration, compliance, and other factors were different among studies. To ensure most subjects are replete in vitamin D, a daily dose of more than 50 microg (2000 IU) in younger and 125 microg (5000 IU) is required. Other strategies including bolus and loading doses are described. No study reported adverse effects of using oral intakes about the current upper level of 50 microg (2000 IU).

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“…An estimated 70% to 90% of patients with hip fracture have insufficient levels of vitamin D [25]. Vitamin D insufficiency is defined as serum 25-hydroxy-vitamin D levels below 32 ng/mL (80 nmol/L).…”

Section: Diagnosis and Treatment Of Diseases Associated With Impairedmentioning

confidence: 99%

Short-term and Long-term Orthopaedic Issues in Patients With Fragility Fractures

Bukata

Kates

O’Keefe

2011

Clinical Orthopaedics &Amp; Related Research

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Background Patients with impaired bone quality who suffer a fragility fracture face substantial challenges in both their short-and long-term care. In addition to poor bone quality, many of these patients have multiple medical comorbidities that alter their surgical risk and affect their ultimate functional recovery. Some medical issues can contribute to the altered bone quality and must be addressed to prevent future fractures. Questions/purposes This review summarizes the modifications in perioperative management and fracture fixation in patients with common fragility fractures who have impaired bone quality. It also summarizes the postoperative diagnosis and treatment of secondary causes of impaired bone quality in these patients. Methods We performed a PubMed search, and literature published after 2000 was prioritized, with the exception of benchmark clinical trial studies published before 2000. Results Patients with altered bone quality require rapid perioperative management of multiple medical comorbidities. Implant selection in patients with poor quality bone should permit early weightbearing, and constructs should maximize surface area contact with the remaining bone. Long-term diagnosis and treatment of other disease states contributing to poor bone quality (vitamin D deficiency/ insufficiency, hypothyroidism, hyperthyroidism, hyperparathyroidism, Cushing's disease, and hypogonadism) must occur to minimize the chances of future fractures. Conclusions Recognition of patients with impaired bone quality and proper treatment of their special needs in both the short and long term are essential for their best opportunity for maximal functional recovery and prevention of future fractures.

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An overview of the prevalence of 25‐hydroxy-vitamin D inadequacy amongst elderly patients with or without fragility fracture in the United Kingdom

Cited by 45 publications

References 21 publications

High-dose oral vitamin D3 supplementation in the elderly

High-dose oral vitamin D3 supplementation in the elderly

Correcting poor vitamin D status: Do older adults need higher repletion doses of vitamin D₃ than younger adults?

Short-term and Long-term Orthopaedic Issues in Patients With Fragility Fractures

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An overview of the prevalence of 25‐hydroxy-vitamin D inadequacy amongst elderly patients with or without fragility fracture in the United Kingdom

Cited by 45 publications

References 21 publications

High-dose oral vitamin D3 supplementation in the elderly

High-dose oral vitamin D3 supplementation in the elderly

Correcting poor vitamin D status: Do older adults need higher repletion doses of vitamin D3 than younger adults?

Short-term and Long-term Orthopaedic Issues in Patients With Fragility Fractures

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Product

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Correcting poor vitamin D status: Do older adults need higher repletion doses of vitamin D₃ than younger adults?