An overview of the potential anticancer properties of cardamonin

Ramchandani, Shanaya; Naz, Irum; Dhudha, Namrata; Garg, Manoj

doi:10.37349/etat.2020.00026

Cited by 13 publications

(7 citation statements)

References 78 publications

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“…As a natural chalcone, CDN is known to possess a range of pharmacological activities, including anti-inflammation and anticancer effects, as well as strong biosafety and pharmacokinetic profiling; therefore, it is considered a promising compound for drug development [ 12 ]. In the present study, we examined the antiviral activity of CDN against human coronavirus HCoV-OC43, finding that its IC 50 value and selectivity index were 3.62 μM and >13.81, respectively, owing to the compound activating the p38 MAPK signaling pathway.…”

Section: Discussionmentioning

confidence: 99%

“…The natural chalcone, cardamonin (2′,4′-dihydroxy-6′-methoxychalcone; CDN) is isolated from the seeds of Alpinia katsumadai Hayata, which belongs to the Zingiberaceae family and has traditionally been used as a remedy for stomach aches and diarrhea. CDN is known to possess various bioactive and pharmacological properties [ 11 ], such as anticancer activity through the regulation of Wint/β-catenin, PI3K/AKT, and NF-kB signaling [ 12 ], anti-inflammatory activity in LPS-stimulated monocytes/macrophages in vitro [ 13 ] and in a paw edema model in vivo [ 14 ], anticoagulative activity through the inhibition of platelet aggregation in human whole blood [ 15 ], antiviral activity through the inhibition of HIV-1 protease [ 16 ] and dengue virus type 2 NS3 protease [ 17 ] activity, antiparasitic activity against Leishmania amazonensis [ 18 ], and antifungal activity against Epidermophyton floccosum [ 19 ]. However, the effects of CDN on human CoVs remain unclear.…”

Section: Introductionmentioning

confidence: 99%

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Cardamonin as a p38 MAPK Signaling Pathway Activator Inhibits Human Coronavirus OC43 Infection in Human Lung Cells

2023

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A natural chalcone, cardamonin (2′,4′-dihydroxy-6′-methoxychalcone; CDN) was isolated from the seeds of Alpinia katsumadai Hayata, which has been traditionally used to treat stomach aches. CDN has been reported to possess various pharmacological properties, including anticancer and anti-inflammatory effects. This study evaluated the antiviral activity of CDN against human coronavirus HCoV-OC43 and determined the mode of action in HCoV-OC43-infected human lung cell lines (MRC-5 and A549 cells). CDN significantly inhibited HCoV-OC43-induced cytopathic effects with an IC50 of 3.62 μM and a CC50 of >50 μM, resulting in a selectivity index of >13.81. CDN treatment reduced the level of viral RNA and the expression of spike and nucleocapsid proteins in HCoV-OC43-infected cells as determine through qRT-PCR and Western blot analysis. Additionally, the activation of p38 mitogen-activated protein kinase (MAPK) by anisomycin decreased viral protein expression, whereas an inhibitor of p38 MAPK signaling, SB202190, increased viral protein expression. CDN also amplified and extended the p38 MAPK signaling pathway in HCoV-OC43-infected cells. In conclusion, CDN inhibited HCoV-OC43 infection by activating the p38 MAPK signaling pathway and has potential as a therapeutic agent against human coronavirus.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cardamonin as a p38 MAPK Signaling Pathway Activator Inhibits Human Coronavirus OC43 Infection in Human Lung Cells

2023

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“…Cardamonin (CAR) is a chalcone isolated from Alpiniae katsumadai . It has been described as an anti-inflammatory and anti-tumor agent in breast, lung, colon, and gastric human cancer cell lines, in both in vitro culture systems as well as xenograft mouse models [ 53 ]. Anticancer activities were demonstrated in different breast cancer cells including drug resistant cancer stem cells [ 54 ], as well as in TNBC [ 55 ].…”

Section: Chalcones and Breast Cancermentioning

confidence: 99%

Anticancer Potential of Natural Chalcones: In Vitro and In Vivo Evidence

Michalkova,

Mirossay,

Kello

et al. 2023

IJMS

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There is no doubt that significant progress has been made in tumor therapy in the past decades. However, the discovery of new molecules with potential antitumor properties still remains one of the most significant challenges in the field of anticancer therapy. Nature, especially plants, is a rich source of phytochemicals with pleiotropic biological activities. Among a plethora of phytochemicals, chalcones, the bioprecursors of flavonoid and isoflavonoids synthesis in higher plants, have attracted attention due to the broad spectrum of biological activities with potential clinical applications. Regarding the antiproliferative and anticancer effects of chalcones, multiple mechanisms of action including cell cycle arrest, induction of different forms of cell death and modulation of various signaling pathways have been documented. This review summarizes current knowledge related to mechanisms of antiproliferative and anticancer effects of natural chalcones in different types of malignancies including breast cancers, cancers of the gastrointestinal tract, lung cancers, renal and bladder cancers, and melanoma.

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“…Cancer is a risk factor for COVID‐19 infection due to a weakened immune system and side effects of chemotherapeutic drugs 2 . Cancer cells can evade the immune system, as they develop different mechanisms that mimic peripheral immune tolerance to avoid tumoricidal attacks by immune cells 3,4 . Therefore, increasingly harsh treatments, such as surgery (to remove the tumor), chemotherapy (targets cells that divide rapidly), and radiotherapy (slow growth by damaging the DNA of cancer cells), are utilized to treat tumors and malignant growths.…”

Section: Introductionmentioning

confidence: 99%

The multifaceted antineoplastic role of pyrimethamine against human malignancies

et al. 2022

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Cancer accounted for nearly 10 million deaths in 2020 and is the second leading cause of death worldwide. The chemotherapeutic agents that are in clinical practice possess a broad range of severe adverse effects towards vital organs which emphasizes the importance of the discovery of new therapeutic agents or repurposing of existing drugs for the treatment of human cancers. Pyrimethamine is an antiparasitic drug used for the treatment of malaria and toxoplasmosis with a well‐documented excellent safety profile. In the last 5 years, numerous efforts have been made to explore the anticancer potential of pyrimethamine in in vitro and in vivo preclinical models and to repurpose it as an anticancer agent. The studies have demonstrated that pyrimethamine inhibits oncogenic proteins such as STAT3, NF‐κB, DX2, MAPK, DHFR, thymidine phosphorylase, telomerase, and many more in a different types of cancer models. Moreover, pyrimethamine has been reported to work in synergy with other anticancer agents, such as temozolomide, to induce apoptosis of tumor cells. Recently, the results of phase‐1/2 clinical trials demonstrated that pyrimethamine administration reduces the expression of STAT3 signature genes in tumor tissues of chronic lymphocytic leukemia patients with a good therapeutic response. In the present article, we have reviewed most of the published articles related to the antitumor effects of pyrimethamine in malignancies of breast, liver, lung, skin, ovary, prostate, pituitary, and leukemia in in vitro and in vivo settings. We have also discussed the pharmacokinetic profile and results of clinical trials obtained after pyrimethamine treatment. From these studies, we believe that pyrimethamine has the potential to be repurposed as an anticancer drug.

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An overview of the potential anticancer properties of cardamonin

Cited by 13 publications

References 78 publications

Cardamonin as a p38 MAPK Signaling Pathway Activator Inhibits Human Coronavirus OC43 Infection in Human Lung Cells

Cardamonin as a p38 MAPK Signaling Pathway Activator Inhibits Human Coronavirus OC43 Infection in Human Lung Cells

Anticancer Potential of Natural Chalcones: In Vitro and In Vivo Evidence

The multifaceted antineoplastic role of pyrimethamine against human malignancies

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