An overview of the pathogenic mechanisms involved in severe cases of COVID-19 infection, and the proposal of salicyl-carnosine as a potential drug for its treatment

Лопачев, А. В.; Kazanskaya, Rogneda B.; Khutorova, A. V.; Федорова, Т. Н.

doi:10.1016/j.ejphar.2020.173457

Cited by 18 publications

(16 citation statements)

References 51 publications

(74 reference statements)

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“…As a result, the unprecedented scale and severity of such a pandemic have aroused increasing interest in various research domains. First, attention was focused in particular on understanding this virus’ pathogenic mechanism [ 3 , 4 ], clinical characteristics and transmission route [ 5 ], as its presence has posed significant challenges to global safety in public health. Compared to SARS, COVID-19 is much more infectious.…”

Section: Introductionmentioning

confidence: 99%

The Changing Patterns of Consumers’ Behavior in China: A Comparison during and after the COVID-19 Pandemic

Yuan

Zhao

et al. 2021

IJERPH

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This paper has an opportunity to collect questionnaire-based data regarding respondents’ life choices in China at the peak of COVID-19 outbreak (i.e., around 9–11 March 2020) and in a relatively stable period where the national pandemic was over and the lockdown policy was halted (i.e., around 25–30 March 2020). Comparing respondents’ answers about their most fundamental aspects of life during and after the pandemic, including income level, expenditure structure and level, purchase method, study method, food price and quality, and dining habit, both the descriptive and econometric models reveal that Chinese consumers’ life patterns were not significantly changed. These findings may imply a “new normal” where consumers stick to their new living habits that were forged during the pandemic. Therefore, policy makers have to envisage such an implicative socio-economic change (cost) brought by the implementation of a lock down policy in a long run, in addition to direct and explicit economic losses. However, improving food quality and controlling food price appear to be the strong and stable safety signals to reassure consumers in this complicated environment.

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Section: Introductionmentioning

confidence: 99%

The Changing Patterns of Consumers’ Behavior in China: A Comparison during and after the COVID-19 Pandemic

Yuan

Zhao

et al. 2021

IJERPH

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“…The unexpected onset of the global health crisis caused many scholars to change their research domains towards pandemic-related areas. A significant number of studies have already been conducted in terms of the medical aspects of the coronavirus-2019, including the understanding of coronavirus-2019 pathogenic mechanism [ 1 ], its transmission routes [ 2 ], and different patterns of symptom development [ 3 , 4 , 5 , 6 ]. Several researchers have already identified obesity; ageing; and comorbidities such as cardiovascular diseases, cancers, and diabetes as risk factors in SARS-CoV-19 patients [ 7 , 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

The Impact of the SARS-CoV-19 Pandemic on the Global Gross Domestic Product

Korneta

Rostek

2021

IJERPH

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The rapid, unexpected, and large-scale expansion of the SARS-CoV-19 pandemic has led to a global health and economy crisis. However, although the crisis itself is a worldwide phenomenon, there have been considerable differences between respective countries in terms of SARS-CoV-19 morbidities and fatalities as well as the GDP impact. The object of this paper was to study the influence of the SARS-CoV-19 pandemic on global gross domestic product. We analyzed data relating to 176 countries in the 11-month period from February 2020 to December 2020. We employed SARS-CoV-19 morbidity and fatality rates reported by different countries as proxies for the development of the pandemic. The analysis employed in our study was based on moving median and quartiles, Kendall tau-b coefficients, and multi-segment piecewise-linear approximation with Theil–Sen trend lines. In the study, we empirically confirmed and measured the negative impact of the SARS-CoV-19 pandemic on the respective national economies. The relationship between the pandemic and the economy is not uniform and depends on the extent of the pandemic’s development. The more intense the pandemic, the more adaptive the economies of specific countries become.

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“…Recently, Kulikova and colleagues (23) developed an analogue of carnosine, salicyl-carnosine, designed to circumvent the rapid degradation by serum carosinase. Salicyl-carnosine effectively mitigates the three prominent pathogenic hallmarks of COVID-19—oxidative stress, thrombosis, and inflammation—and has been proposed as a promising means to treat severe cases of COVID-19 (24).…”

Section: Discussionmentioning

confidence: 99%

Small-molecule metabolome identifies potential therapeutic targets against COVID-19

Bennet

Kaufmann

Takami

et al. 2021

Preprint

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Background: Respiratory viruses are transmitted and acquired via the nasal mucosa, and thereby may influence the nasal metabolome composed of biochemical products produced by both host cells and microbes. Studies of the nasal metabolome demonstrate virus-specific changes that sometimes correlate with viral load and disease severity. Here, we evaluate the nasopharyngeal metabolome of COVID-19 infected individuals and report several small molecules that may be used as potential therapeutic targets. Specimens were tested by qRT-PCR with target primers for three viruses: Influenza A (INFA), respiratory syncytial virus (RSV), and SARS-CoV-2, along with asymptomatic controls. The nasopharyngeal metabolome was characterized using an LC-MS/MS-based small-molecule screening kit capable of quantifying 141 analytes. A machine learning model identified 28 discriminating analytes and correctly categorized patients with a viral infection with an accuracy of 96% (R2=0.771, Q2=0.72). A second model identified 5 analytes to differentiate COVID19-infected patients from those with INFA or RSV with an accuracy of 85% (R2=0.442, Q2=0.301). Specifically, LysoPCaC18:2 concentration was significantly increased in COVID19 patients (P< 0.0001), whereas beta-hydroxybutyric acid, Met SO, succinic acid, and carnosine concentrations were significantly decreased (P< 0.0001). This study demonstrates that COVID19 infection results in a unique NP metabolomic signature with carnosine and LysoPCaC18:2 as potential therapeutic targets.

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An overview of the pathogenic mechanisms involved in severe cases of COVID-19 infection, and the proposal of salicyl-carnosine as a potential drug for its treatment

Cited by 18 publications

References 51 publications

The Changing Patterns of Consumers’ Behavior in China: A Comparison during and after the COVID-19 Pandemic

The Changing Patterns of Consumers’ Behavior in China: A Comparison during and after the COVID-19 Pandemic

The Impact of the SARS-CoV-19 Pandemic on the Global Gross Domestic Product

Small-molecule metabolome identifies potential therapeutic targets against COVID-19

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