An overview of the neuroprotective potential of rosmarinic acid and its association with nanotechnology-based delivery systems: A novel approach to treating neurodegenerative disorders

Fachel, Flávia Nathiely Silveira; Schuh, Roselena Silvestri; Veras, Kleyton Santos; Bassani, Valquíria Linck; Koester, Letícia Scherer; Henriques, Amélia Teresinha; Braganhol, Elizandra; Teixeira, Hélder Ferreira

doi:10.1016/j.neuint.2018.11.003

Cited by 49 publications

(34 citation statements)

References 130 publications

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“…According to the reported polymeric phenolic acids in Labiatae, the condensation for the formation of polymers is mostly based on the processes of dehydration (−H 2 O), dehydrogenation (−2H) and occasionally decarbonylation (−CO or −CO 2 ). Rosmarinic acid (dimer), lithospermic acid (trimer) and salvianolic acid B (tetramer) are very interesting for their significant anti‐urolithiasis, antidiabetic, anticancer, anti‐inflammatory and antibacterial activities …”

Section: Introductionmentioning

confidence: 99%

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Characterization of polymeric phenolic acids and flavonoids in Clerodendranthi Spicati Herba using ultrahigh‐performance liquid chromatography coupled to quadrupole time‐of‐flight tandem mass spectrometry with target and nontarget data mining strategy

Luo

Wen

Lai

et al. 2019

Rapid Comm Mass Spectrometry

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Rationale Clerodendranthi Spicati Herba (CSH) is often used to treat urinary stones, urinary tract infections and nephritis in China. Much literature has reported that polymeric phenolic acids and flavonoids are the major bioactive components in CSH. Therefore, it is very meaningful to identify the polymeric phenolic acids and flavonoids in CSH. Methods Ultrahigh‐performance liquid chromatography coupled to quadrupole time‐of‐flight tandem mass spectrometry (UHPLC/QTOF‐MS/MS) analysis with target and nontarget data mining strategy was proposed to rapidly profile the polymeric phenolic acids and flavonoids in CSH. Diagnostic product ions and neutral loss filter were beneficial for identifying the polymeric phenolic acids and flavonoids from complex compounds in CSH. Results A total of 118 compounds, including 85 polymeric phenolic acids and 33 flavonoids, were reasonably identified in CSH by comparing their main fragmentation pathways with literature data, and 85 of them were discovered in CSH firstly by nontarget analysis. Nine potential compounds were characterized tentatively as new pentameric and hexameric phenolic acids in CSH. Six types of polymeric phenolic acids (monomer, dimer, trimer, tetramer, pentamer and hexamer) and four types of flavonoids (apigenin, kaempferol, luteolin and quercetin) were identified in CSH. Conclusions The results indicated that the UHPLC/QTOF‐MS/MS method coupled with target and nontarget data mining strategy was feasible and rational for identifying the polymeric phenolic acids and flavonoids in complex chemical constituents of CSH. The findings will be conducive to the discovery of the active ingredients of CSH and the establishment of quality standards.

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Section: Introductionmentioning

confidence: 99%

“…12 activities. [13][14][15] Using UHPLC-QTOF-MS/MS to quickly and efficiently identify target compounds from complex constituents of traditional Chinese medicine had been a challenge. However, many methods have been developed to solve this problem, including mass defect filter, diagnostic product ions and neutral loss filter.…”

Section: Introductionmentioning

confidence: 99%

Characterization of polymeric phenolic acids and flavonoids in Clerodendranthi Spicati Herba using ultrahigh‐performance liquid chromatography coupled to quadrupole time‐of‐flight tandem mass spectrometry with target and nontarget data mining strategy

Luo

Wen

Lai

et al. 2019

Rapid Comm Mass Spectrometry

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“…RA is commonly found in a wide range of medicinal plants, mainly from the Boraginaeae and Lamiaceae families, such as rosemary ( Rosmarinus officinalis L.), mint ( Mentha spp.) and lemon balm ( Melissa oficcinalis L.) . RA has various biological activities of pharmaceutical interest described in the literature, including anti‐inflammatory, antimelanogenic, antitumor, antiviral and a well‐documented antioxidant activity .…”

Section: Introductionmentioning

confidence: 99%

“…[9,10] RA has various biological activities of pharmaceutical interest described in the literature, including anti-inflammatory, antimelanogenic, antitumor, antiviral and a welldocumented antioxidant activity. [7,[10][11][12][13][14] In 1994, Huang et al [15] demonstrated that rosemary extract containing a great amount of RA was able to slow lipid peroxidation. It occurred mainly due to its antioxidant potential associated with its ability to eliminate free radicals, which represents one of RA most relevant biological activity.…”

Section: Introductionmentioning

confidence: 99%

Development, physico-chemical characterization and in-vitro studies of hydrogels containing rosmarinic acid-loaded nanoemulsion for topical application

Marafon

Fachel

Prá

et al. 2019

Journal of Pharmacy and Pharmacology

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Objectives Natural sources with antioxidant activity, such as rosmarinic acid (RA), have been considered as an interesting approach for the development of new anti‐ageing skin products. In this context, this study aimed to develop hydrogels containing RA‐loaded nanoemulsions and evaluate the effect of the addition of Tween® 80 (a nonionic cosurfactant) in formulations intended to be used for topical application. Methods Physico‐chemical characterization, in‐vitro release and skin retention/permeation from hydrogels of RA‐loaded nanoemulsions (containing or not Tween® 80) were evaluated. The RA‐loaded nanoemulsion safety profiles were also investigated in keratinocytes (HaCaT cells). Key findings It was observed that all formulations presented adequate physico‐chemical characterization for topical application. Furthermore, the results also demonstrated that the presence of Tween® 80 decreased the droplet size and polydispersity index of nanoemulsions and hydrogels. An extended RA release was noted for the hydrogels. However, when comparing the hydrogels, a positive effect of the presence of Tween® 80 on RA retention/permeation in total skin was seen. The RA‐loaded nanoemulsion safety profiles demonstrated a good tolerability (3.125–100 μm) in HaCaT cells. Conclusions The overall results demonstrated that the formulations developed in this study can be considered as a suitable carrier for RA in a topical application targeting new anti‐ageing skin care products.

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“…It has numerous biological activities, including a current welldocumented anti-inflammatory and antioxidant activities recently associated to a neuroprotective potential [1][2][3][4][5][6]. Nevertheless, besides the RA poor bioavailability and availability in the central nervous system (CNS), in view of its limited ability to cross the blood-brain barrier (BBB), some alternatives to RA delivery, protection, and release been investigated intended to be used as a new neuroprotective therapy [1,7,8]. Nasal route has been emerged as an alternative strategy for drugs delivery directly to CNS, owing to its ability to by passing BBB, an important obstacle for the delivery of therapeutic agents [9].…”

Section: Introductionmentioning

confidence: 99%

Sensitive ultra-fast liquid chromatography method for rosmarinic acid determination in Wistar rat’s plasma and brain

et al. 2019

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Rosmarinic acid (RA) is a polyphenolic compound recently associated to a neuroprotective potential. Nevertheless, besides the RA poor bioavailability and availability in the central nervous system (CNS) some alternatives to RA delivery, protection, and release been investigated. Recently, our research group optimized chitosan-coated nanoemulsions for RA nasal administration and demonstrated the glioprotective effect against LPS-induced damage in astrocytes. In this context, this study aimed to validate a fast, simplified and stability-indicating UFLC method previously reported by our research group for RA determination in Wistar rat’s plasma and brain, to be employed in further in vivo studies, since the nasal route for RA are not completely understood. The method was validated in terms of specificity, linearity, matrix effect, stability, precision, accuracy and extraction recovery for rat plasma and brain, according to the official guidelines. The method was sensitive, linear (0.1 - 10 µg.mL−1), precise and accurate, and showed RA recovery higher than 85% in plasma and brain. Overall results demonstrated that method was successfully validated for determination of RA in rat plasma and brain matrices with high sensibility and with high recovery using simple extraction processes.

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An overview of the neuroprotective potential of rosmarinic acid and its association with nanotechnology-based delivery systems: A novel approach to treating neurodegenerative disorders

Cited by 49 publications

References 130 publications

Characterization of polymeric phenolic acids and flavonoids in Clerodendranthi Spicati Herba using ultrahigh‐performance liquid chromatography coupled to quadrupole time‐of‐flight tandem mass spectrometry with target and nontarget data mining strategy

Characterization of polymeric phenolic acids and flavonoids in Clerodendranthi Spicati Herba using ultrahigh‐performance liquid chromatography coupled to quadrupole time‐of‐flight tandem mass spectrometry with target and nontarget data mining strategy

Development, physico-chemical characterization and in-vitro studies of hydrogels containing rosmarinic acid-loaded nanoemulsion for topical application

Sensitive ultra-fast liquid chromatography method for rosmarinic acid determination in Wistar rat’s plasma and brain

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