An overview of the implementation of SeDeM and SSCD in various formulation developments

Gaikwad, Sachin S.; Kothule, Akshada M.; Morade, Yogita Y.; Patil, Sakshi S.; Laddha, Umesh D.; Kshirsagar, Sanjay J.; Salunkhe, Kishor S.

doi:10.1016/j.ijpharm.2023.122699

Cited by 5 publications

(4 citation statements)

References 28 publications

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“…The compressibility and flowability of the hydrogel were measured using Carr's Index and the Hausner ratio 46 . These measurements are also used for handling, packaging, and transporting dried samples 47 .…”

Section: Resultsmentioning

confidence: 99%

“…The compressibility and flowability of the hydrogel were measured using Carr's Index and the Hausner ratio. 46 These measurements are also used for handling, packaging, and transporting dried samples. 47 In Carr's Index, lower compressibility leads to higher relative flowability, while a lower Hausner value indicates better flow properties.…”

Section: Carr's Index and Hausner's Ratiomentioning

confidence: 99%

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Controlled release of urea using negatively charged polysaccharides

John Kennedy,

Muthuramalingam,

Balasubramanian

et al. 2024

Polymers for Advanced Techs

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The current study aims to synthesize cross‐linked alginate–gum arabic, a polysaccharide biopolymer composite, to evaluate its efficacy for the controlled release of urea. The alginate–gum arabic solution was prepared in a 2:1 ratio, and urea was entrapped in three different amounts: 50 mg for SG1, 100 mg for SG2, and 150 mg for SG3. CaCl2 used as the crosslinker, and the urea‐entrapped alginate–gum arabic hydrogel beads were produced using ionotropic gelation method. Produced beads were underwent physical evaluation to analyze their size, porosity, and swelling behavior. The highest diameter was exhibited in SG3 at 3.60 ± 0.01 mm. Additionally, the highest porosity was observed in SG3 beads, measuring 63.6% ± 0.33%. The release of urea was quantified using the DiacetylMonoxim (DAM)–UV visible spectroscopy method. Further, the characterization of the produced hydrogel beads was analyzed using Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and thermogravimetric analyses (TGA). FTIR revealed the characteristic band at 3770 and 2355 cm−1, indicating the presence of urea entrapped in alginate—gum arabic beads. TGA analyses indicates that the good thermal stability of the produced beads.

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Section: Resultsmentioning

confidence: 99%

Section: Carr's Index and Hausner's Ratiomentioning

confidence: 99%

Controlled release of urea using negatively charged polysaccharides

John Kennedy,

Muthuramalingam,

Balasubramanian

et al. 2024

Polymers for Advanced Techs

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“…By evaluating these parameters and tracing the SSCDs, a prediction regarding the product quality can be made. The parameters evaluated are organoleptic properties, viscosity, extensibility, water loss, and centrifugation, all of them being detailed in the sections below [27,32].…”

Section: The Evaluation Of the Proposed Hydrogel Using Sscdsmentioning

confidence: 99%

Impact of the Preparation Method on the Formulation Properties of Allantoin Hydrogels: Evaluation Using Semi-Solid Control Diagram (SSCD) Principles

Vlad,

Dudici (Vlăgea),

Syed

et al. 2024

Gels

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Allantoin possesses numerous beneficial properties for the skin, like anti-irritant effects, wound healing, skin hydration, and epithelization. In this paper, we investigated a suitable preparation method for an allantoin hydrogel using the Semi-Solid Control Diagram (SSCD) method and characterized its rheological and consistency behavior. To accomplish this, xanthan gum (XG) was selected as a model gelling agent. Briefly, four hydrogels were prepared, two without allantoin (coded M01 and M02) and two with allantoin (M1 and M2). Similarly, the formulations were either prepared through magnetic stirring (M01 and M1) or homogenization in a mortar (M02 and M2). The prepared hydrogels were evaluated using the SSCD for specific parameters and indexes. The Good Quality Index (GQI) shows a higher value for the formulation, M1 = 6.27, compared to M2 = 5.45. This result is also underlined by the value of M01 = 6.45, which is higher than M02 = 6.38. Considering the consistency, the formulation M01 possessed the highest spreadability, followed by M02 and then the allantoin hydrogels M1 and M2. The rheological behavior had a thixotropic pseudoplastic flow for all the formulations. The use of SSCD pictographs outlined the rheological properties that need improvement, the method that is suitable to prepare the allantoin hydrogels, and the influence of the allantoin suspended in the XG hydrogel.

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“…A recent technology to convey natural actives is the phytosomes, which are vesicles containing plant extracts bound by a lipid, ensuring adequate pharmacokinetic properties and dynamics, to increase bioavailability. These are systems of micellar arrangements formed by the interaction between water and phospholipids and once delineated with encapsulated polyphenolic extracts, enhances molecular interaction and cellular permeation, improving the miscibility of phytoconstituents [32] . The active constituents are usually hydrophilic and react with the structural lipid to form a complex.…”

Section: Nanosystemsmentioning

confidence: 99%

Nanotechnology Formulations Designed with Herbal Extracts and Their Therapeutic Applications – A Review

Silva

Ferreira

Soares

2023

Chemistry & Biodiversity

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Because of the increasing demand for natural products, the development of nanoformulations containing natural active ingredients requires in‐depth knowledge of the substances used, methods of obtaining, and stability profiles to ensure product quality, efficacy, and safety. Considering this, the bibliography of the last five years presented in databases (PubMed and Science Direct) was discussed in this work, discussing the study with medicinal plants to obtain active metabolites with therapeutic properties, as well as the different nano‐systems responsible for carrying these molecules. Due to the wealth of biodiversity found in the world, many species are submitted to the extraction process for several purposes. However, identifying, classifying, and quantifying the constituents of herbal matrices are crucial steps to verify their therapeutic potential. In addition, knowing the techniques of production and elaboration of nanotechnology products allows the optimization of the incorporation of herbal extracts as an innovation target. For studies to be successful, it is necessary to exhaust experimental results that guarantee the efficacy, safety, and quality of natural nanosystems, with the objective of obtaining reliable answers in nanotechnology therapy.

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An overview of the implementation of SeDeM and SSCD in various formulation developments

Cited by 5 publications

References 28 publications

Controlled release of urea using negatively charged polysaccharides

Controlled release of urea using negatively charged polysaccharides

Impact of the Preparation Method on the Formulation Properties of Allantoin Hydrogels: Evaluation Using Semi-Solid Control Diagram (SSCD) Principles

Nanotechnology Formulations Designed with Herbal Extracts and Their Therapeutic Applications – A Review

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