An overview of the immune response and Arginase I on CHIKV immunopathogenesis

Pereira, Ana Paula Lombardi; Suzukawa, Helena Tiemi; Nascimento, Aline Miquelin do; Kawassaki, Aedra Carla Bufalo; Basso, Camila Regina; Santos, Dayane Priscila dos; Damasco, Kamila Falchetti; Machado, Laís Fernanda; Amarante, Marla Karine; Watanabe, Maria Angélica Ehara

doi:10.1016/j.micpath.2019.103581

Cited by 2 publications

(1 citation statement)

References 52 publications

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“…For example, the expression of Arg-I has been shown to be associated with an increased viral load, disease severity, and persistence of the Chikungunya virus, which, like DENV, is transmitted by the Ae. aegypti mosquito [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Dengue Virus Infection of Aedes aegypti Alters Extracellular Vesicle Protein Cargo to Enhance Virus Transmission

Gold

Feitosa-Suntheimer

Araujo

et al. 2020

IJMS

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Dengue is the most burdensome vector-borne viral disease in the world. Dengue virus (DENV), the etiological cause of dengue, is transmitted primarily by the Aedes aegypti mosquito. Like any arbovirus, the transmission cycle of dengue involves the complex interactions of a multitude of human and mosquito factors. One point during this transmission cycle that is rich in these interactions is the biting event by the mosquito, upon which its saliva is injected into the host. A number of components in mosquito saliva have been shown to play a pivotal role in the transmission of dengue, however one such component that is not as well characterized is extracellular vesicles. Here, using high-performance liquid chromatography in tandem with mass spectrometry, we show that dengue infection altered the protein cargo of Aedes aegypti extracellular vesicles, resulting in the packaging of proteins with infection-enhancing ability. Our results support the presence of an infection-dependent pro-viral protein packaging strategy that uses the differential packaging of pro-viral proteins in extracellular vesicles of Ae. aegypti saliva to promote transmission. These studies represent the first investigation into the function of Ae. aegypti extracellular vesicle cargo during dengue infection.

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Section: Discussionmentioning

confidence: 99%

Dengue Virus Infection of Aedes aegypti Alters Extracellular Vesicle Protein Cargo to Enhance Virus Transmission

Gold

Feitosa-Suntheimer

Araujo

et al. 2020

IJMS

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Persistent Joint Pain Following Arthropod Virus Infections

et al. 2021

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Purpose of Review Persistent joint pain is a common manifestation of arthropod-borne viral infections and can cause long-term disability. We review the epidemiology, pathophysiology, diagnosis, and management of arthritogenic alphavirus infection. Recent findings The global re-emergence of alphaviral outbreaks has led to an increase in virus-induced arthralgia and arthritis. Alphaviruses, including Chikungunya, O’nyong’nyong, Sindbis, Barmah Forest, Ross River, and Mayaro viruses, are associated with acute and/or chronic rheumatic symptoms. Identification of Mxra8 as a viral entry receptor in the alphaviral replication pathway creates opportunities for treatment and prevention. Recent evidence suggesting virus does not persist in synovial fluid during chronic chikungunya infection indicates that immunomodulators may be given safely. Summary The etiology of persistent joint pain after alphavirus infection is still poorly understood. New diagnostic tools along and evidence-based treatment could significantly improve morbidity and long-term disability.

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An overview of the immune response and Arginase I on CHIKV immunopathogenesis

Cited by 2 publications

References 52 publications

Dengue Virus Infection of Aedes aegypti Alters Extracellular Vesicle Protein Cargo to Enhance Virus Transmission

Dengue Virus Infection of Aedes aegypti Alters Extracellular Vesicle Protein Cargo to Enhance Virus Transmission

Persistent Joint Pain Following Arthropod Virus Infections

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