An overview of the current clinical status of optical imaging in head and neck cancer with a focus on Narrow Band imaging and fluorescence optical imaging

Schaik, Jeroen E. van; Halmos, György B.; Witjes, Max J. H.; Plaat, Boudewijn E. C.

doi:10.1016/j.oraloncology.2021.105504

Cited by 19 publications

(21 citation statements)

References 89 publications

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“…Other optical techniques, such as narrow-band imaging (NBI), have shown promising results in tumor diagnosis in the upper aerodigestive tract with an overall sensitivity and specificity of 89% and 96% [ 34 ]. This technique differs fundamentally from CLE.…”

Section: Discussionmentioning

confidence: 99%

Validity of tissue homogeneity in confocal laser endomicroscopy on the diagnosis of laryngeal and hypopharyngeal squamous cell carcinoma

Sievert

Aubreville

Gostian

et al. 2022

Eur Arch Otorhinolaryngol

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Purpose Confocal laser endomicroscopy (CLE) allows imaging of the laryngeal mucosa in a thousand-fold magnification. This study analyzes differences in tissue homogeneity between healthy mucosa and squamous cell carcinoma (SCC) via CLE. Materials and methods We included five SCC patients with planned total laryngectomy in this study between October 2020 and February 2021. We captured CLE scans of the tumor and healthy mucosa. Analysis of image homogeneity to diagnose SCC was performed by measuring the signal intensity in four regions of interest (ROI) in each frame in a total of 60 sequences. Each sequence was assigned to the corresponding histological pattern, derived from hematoxylin and eosin staining. In addition, we recorded the subjective evaluation of seven investigators regarding tissue homogeneity. Results Out of 3600 images, 1620 (45%) correlated with benign mucosa and 1980 (55%) with SCC. ROIs of benign mucosa and SCC had a mean and standard deviation (SD) of signal intensity of, respectively, 232.1 ± 3.34 and 467.3 ± 9.72 (P < 0.001). The mean SD between the four different ROIs was 39.1 ± 1.03 for benign and 101.5 ± 2.6 for SCC frames (P < 0.001). In addition, homogeneity yielded a sensitivity and specificity of 81.8% and 86.2%, respectively, regarding the investigator-dependent analysis. Conclusions SCC shows a significant tissue inhomogeneity in comparison to the healthy epithelium. The results support this feature’s importance in identifying malignant mucosa areas during CLE examination. However, the examiner-dependent evaluation emphasizes that homogeneity is a sub-criterion that must be considered in a broad context.

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Section: Discussionmentioning

confidence: 99%

Validity of tissue homogeneity in confocal laser endomicroscopy on the diagnosis of laryngeal and hypopharyngeal squamous cell carcinoma

Sievert

Aubreville

Gostian

et al. 2022

Eur Arch Otorhinolaryngol

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“…However, identifying specific biomarkers for OSCC imaging is urgently required. Previous studies on OSCC imaging have mainly focused on EGFR, 41 PARP1 42 and c‐Met 43 as imaging biomarkers 13 . However, tumors are heterogeneous and the current understanding of OSCC imaging biomarkers is unclear; hence, it is necessary to investigate more promising potential imaging biomarkers 44 .…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies on OSCC imaging have mainly focused on EGFR, 41 PARP1 42 and c-Met 43 as imaging biomarkers. 13 However, tumors are heterogeneous and the current understanding of OSCC imaging biomarkers is unclear; hence, it is necessary to investigate more promising potential imaging biomarkers. 44 In the present study, GLUT1 was identified as a new potential biomarker for OSCCtargeted imaging.…”

Section: Biosafety Of Wzb117-ir820mentioning

confidence: 99%

“…In addition, autofluorescence imaging (AFI) is limited by high false positives, possibly due to the change in autofluorescence induced by scarring, blood, bacterial overgrowth or inflammation 12 . Furthermore, narrow‐band imaging (NBI) is prone to excessive subjective interpretation and is restricted by an extended study time 13 . Traditional surgery primarily depends on the surgeon's vision and tactile sense to identify tumor margins, which is very subjective and limited.…”

Section: Introductionmentioning

confidence: 99%

“…12 Furthermore, narrow-band imaging (NBI) is prone to excessive subjective interpretation and is restricted by an extended study time. 13 Traditional surgery primarily depends on the surgeon's vision and tactile sense to identify tumor margins, which is very subjective and limited. Incomplete removal, defined by positive margins, affects survival in patients with OSCC.…”

Section: Introductionmentioning

confidence: 99%

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Novel fluorescent GLUT1 inhibitor for precision detection and fluorescence image‐guided surgery in oral squamous cell carcinoma

Tian

Tang

Shi

et al. 2022

Intl Journal of Cancer

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Early detection and complete resection of oral squamous cell carcinoma (OSCC) are crucial to improving patient survival and prognosis. However, specifically targeted imaging probes for OSCC detection are limited. Our study aimed to synthesize a novel near-infrared fluorescence (NIRF) probe for precision detection and fluorescence image-guided surgery in OSCC. Bioinformatics data indicated that glucose transporter 1 (GLUT1) is highly expressed in patients with OSCC. We demonstrated high and specific GLUT1 expression upon immunohistochemical staining of samples from 20 patients with OSCC. The specific expression of GLUT1 was further validated in both human OSCC cell lines and OSCC tumor xenografts. Based on these findings, the GLUT1 inhibitor WZB117 was utilized to synthesize a novel NIRF imaging probe, WZB117-IR820. The fluorescence molecular imaging data revealed that WZB117-IR820 could specifically bind to the tumor areas in an orthotopic OSCC mouse model after intravenous injection and could be further applied for precision fluorescence image-guided surgery with no residual tumor in the orthotopic CAL27-fLUC mouse tumor model. For further clinical translational application in patients with OSCC, precise delineation of OSCC tumor areas was achieved after topical application of the WZB117-IR820 imaging probe and was validated by histopathological and immunohistochemical analyses. In conclusion, we synthesized a novel fluorescent imaging probe, WZB117-IR820, which has potential clinical applications for early detection and fluorescence image-guided surgery in OSCC with no observable toxicity.

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Discrimination of vocal folds lesions by multiclass classification using autofluorescence spectroscopy: An ex vivo study

Gaiffe,

Mahdjoub,

Ramasso

et al. 2024

Head & Neck

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BackgroundAutofluorescence spectroscopy is effective for noninvasive detection but underutilized in tissue with various pathology analyses. This study evaluates whether AFS can be used to discriminate between different types of laryngeal lesions in view of assisting in vocal fold surgery and preoperative investigations.MethodsA total of 1308 spectra were recorded from 29 vocal fold samples obtained from 23 patients. Multiclass analysis was performed on the spectral data, categorizing lesions into normal, benign, dysplastic, or carcinoma.ResultsThrough an appropriate selection of spectral components and a cascading classification approach based on artificial neural networks, a classification rate of 97% was achieved for each lesion class, compared to 52% using autofluorescence intensity.ConclusionsThe ex vivo study demonstrates the effectiveness of AFS combined with multivariate analysis for accurate classification of vocal fold lesions. Comprehensive analysis of spectral data significantly improves classification accuracy, such as distinguishing malignant from precancerous or benign lesions.

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An overview of the current clinical status of optical imaging in head and neck cancer with a focus on Narrow Band imaging and fluorescence optical imaging

Cited by 19 publications

References 89 publications

Validity of tissue homogeneity in confocal laser endomicroscopy on the diagnosis of laryngeal and hypopharyngeal squamous cell carcinoma

Validity of tissue homogeneity in confocal laser endomicroscopy on the diagnosis of laryngeal and hypopharyngeal squamous cell carcinoma

Novel fluorescent GLUT1 inhibitor for precision detection and fluorescence image‐guided surgery in oral squamous cell carcinoma

Discrimination of vocal folds lesions by multiclass classification using autofluorescence spectroscopy: An ex vivo study

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