An overview of the clinical use of ondansetron in preschool age children

Cohen, Ira Todd

doi:10.2147/tcrm.2007.3.2.333

Cited by 14 publications

(11 citation statements)

References 71 publications

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“…When used together, these two drugs are relatively free of significant adverse effects. 16,17 Similar benefit has been observed for a combination of dexamethasone and another serotonin antagonist, tropisetron. 18 It is also likely that the lowest dose of dexamethasone (0.0625 mg/kg) is as effective as higher doses in achieving a beneficial antiemetic effect.…”

Section: Discussionmentioning

confidence: 59%

Post-operative nausea and vomiting following paediatric day-case tonsillectomy: audit of the Epsom protocol

Robb

Ewah

2011

J. Laryngol. Otol.

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Section: Discussionmentioning

confidence: 59%

Post-operative nausea and vomiting following paediatric day-case tonsillectomy: audit of the Epsom protocol

Robb

Ewah

2011

J. Laryngol. Otol.

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“…Another prospective, randomized, double-blind study showed that intravenous prophylactic ranitidine and metoclopramide is useful to reduce the volume of gastric content and increase gastric pH [11]. In our study, use of ranitidine and metoclopramide injection was very common, and ondansetron, a 5 HT3 antagonist [17,18] was given to all patients undergoing exploratory laparotomy.…”

Section: Discussionmentioning

confidence: 78%

Pre-Anesthetic Medications in Patients Undergoing Exploratory Laparotomy: Results of a Cross-Sectional Study

Patil

Kulkarni

2018

Asian J Pharm Clin Res

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Objective: The objective of this study was to understand the pattern of pre-anesthetic medication utilization in patients undergoing exploratory laparotomy. Methods:In this cross-sectional study, we reviewed the records of patients who underwent exploratory laparotomy under general anesthesia. Descriptive data of the pre-anesthetic medications used in the patients are presented. Results:A total of 49 patients with mean ± SD age of 65.85±34.15 years were included in the study. The study population was dominated by male patients (65.85%). Two major indications for exploratory laparotomy in the study population were perforation peritonitis 19 (38.77%) and intestinal obstruction 9 (18.37%). Ondansetron was used in all patients. Metoclopramide and ranitidine were used in 48 (98%) patients each. Midazolam was given to 43 (87.8%) patients. A total of 41 (83.7%) patients received anticholinergic agent glycopyrrolate or atropine. Pentazocine and fentanyl were used in 39 (79.6%) and 10 (20.4%) patients, respectively. Conclusion:Ondansetron, metoclopramide, ranitidine, midazolam, glycopyrrolate, and pentazocine were the major pre-anesthetic medications in patients undergoing exploratory laparotomy. Glycopyrrolate was the most preferred anticholinergic agent.

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“…It is one of the best known potent serotonin 5-HT3 receptor-antagonists that blocks receptors at the vagus and sympathetic nerves together with the chemoreceptor trigger zones 64. It has no antidopaminergic properties.…”

Section: Antiemetic Medicationsmentioning

confidence: 99%

Acute gastroenteritis: from guidelines to real life

Chow

Leung²,

Hon³

2010

CEG

108

100

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Acute gastroenteritis is a very common disease. It causes significant mortality in developing countries and significant economic burden to developed countries. Viruses are responsible for approximately 70% of episodes of acute gastroenteritis in children and rotavirus is one of the best studied of these viruses. Oral rehydration therapy is as effective as intravenous therapy in treating mild to moderate dehydration in acute gastroenteritis and is strongly recommended as the first line therapy. However, the oral rehydration solution is described as an underused simple solution. Vomiting is one of the main reasons to explain the underuse of oral rehydration therapy. Antiemetics are not routinely recommended in treating acute gastroenteritis, though they are still commonly prescribed. Ondansetron is one of the best studied antiemetics and its role in enhancing the compliance of oral rehydration therapy and decreasing the rate of hospitalization has been proved recently. The guidelines regarding the recommendation on antiemetics have been changed according to the evidence of these recent studies.

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An overview of the clinical use of ondansetron in preschool age children

Cited by 14 publications

References 71 publications

Post-operative nausea and vomiting following paediatric day-case tonsillectomy: audit of the Epsom protocol

Post-operative nausea and vomiting following paediatric day-case tonsillectomy: audit of the Epsom protocol

Pre-Anesthetic Medications in Patients Undergoing Exploratory Laparotomy: Results of a Cross-Sectional Study

Acute gastroenteritis: from guidelines to real life

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