An Overview of the Biology of Platelet-Rich Plasma and Microneedling as Potential Treatments for Alopecia Areata

Strazzulla, Lauren C.; Avila, Lorena; Sicco, Kristen Lo; Shapiro, Jerry

doi:10.1016/j.jisp.2017.10.002

Cited by 20 publications

(17 citation statements)

References 26 publications

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“…The GFs of PRP stimulated proliferation of adipose tissue-derived stem cells to accelerate wound healing ( Scioli et al., 2017 ; Emer, 2019 ). On the basis that PRP can promote wound repair, PRP was employed to treat hair loss ( Stevens & Khetarpal, 2019 ; Strazzulla et al., 2018 ). Recently, PRP has been demonstrated as an effective alternative treatment with minimal side-effects for hair disorders ( Strazzulla et al., 2018 ), but the exact mechanisms and effects of specific components of PRP have not been uncovered.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, this technique has been explored in the field of dermatology including wound healing, scar revision, skin rejuvenation, fat graft and so on ( Emer, 2019 ). Furthermore, PRP has also been demonstrated as an efficient cure to treat hair disorders, such as androgenetic alopecia, owing to its autologous, least injuries, less adverse effects, and more acceptable cost in comparison to hair implantation ( Strazzulla et al., 2018 ). Evidence indicates that when injected into scalp, platelets in PRP become activated and secrete a series of cytokines andgrowth factors , like insulin like growth factor-1 (IGF-1), platelet-derived growth factor and epidermal growth factor from their alpha granules, which may promote hair growth ( Mussano et al., 2016 ; Emer, 2019 ; Cervantes et al., 2018 ).…”

Section: Introductionmentioning

confidence: 99%

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Platelet factor 4 inhibits human hair follicle growth and promotes androgen receptor expression in human dermal papilla cells

Sha

Chen

Liu

et al. 2020

PeerJ

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Platelet-rich plasma (PRP) has been reported recently as a potential therapeutic approach for alopecia, such as androgenetic alopecia, but the exact mechanisms and effects of specific components of this recipe remain largely unknown. In this study, we identified that platelet factor 4 (PF4), a component of PRP, significantly suppressed human hair follicle growth and restrained the proliferation of human dermal papilla cells (hDPCs). Furthermore, our results showed that PF4 upregulated androgen receptor (AR) in human dermal papilla cells in vitro and via hair follicle organ culture. Among the hair growth-promoting and DP-signature genes investigated, PF4 decreased the expression of Wnt5a, Wnt10b, LEF1, HEY1 and IGF-1, and increased DKK1 expression, but did not affect BMP2 and BMP4 expression. Collectively, Our data demonstrate that PF4 suppresses human hair follicle growth possibly via upregulating androgen receptor signaling and modulating hair growth-associated genes, which provides thought-provoking insights into the application and optimization of PRP in treating hair loss.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Platelet factor 4 inhibits human hair follicle growth and promotes androgen receptor expression in human dermal papilla cells

Sha

Chen

Liu

et al. 2020

PeerJ

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“…They used a depth of 0.5 mm for the dermaroller for this study with TAC (10 mg/mL) applied immediately before microneedling [7]. Despite significant responses to this treatment, quantification of hair density, before and after treatment, was not provided [7,8].…”

Section: Casementioning

confidence: 99%

Successful Treatment of Alopecia Areata Patches with Triamcinolone Acetonide Using MMP®: Report of 2 Cases

Barletta

Gasques

2020

Skin Appendage Disord

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Intralesional (IL) injection of corticosteroids is an effective treatment of alopecia areata (AA). A novel drug delivery technique that uses a tattoo machine (MMP®) has been successfully used to treat other skin disorders. We tested this technique to treat AA. We used the Cheyenne dermopigmentation machine (Anvisa 80281110016; Germany) with a 27 Magnum needle cartridge (Anvisa 80281110015) at a frequency of 70 Hz and needle depth of 1.0 mm. A triamcinolone acetonide (TAC) solution was placed in a sterile receptacle and loaded onto the cartridge by capillarity. We produced micropunctures of the skin with the medication-soaked needles until the affected area was covered by a bloody dew. Case 1: J.C.V., a male, with a diagnosis of AA in patches was treated with 1-monthly session with 2.5 mg/mL TAC delivered by MMP® (4 sessions in total). Case 2: L.M.V., a 78-year-old female with a diagnosis of AA was treated with 1-monthly session with 10 mg/mL TAC delivered by MMP® (4 sessions in total). MMP® is a novel technique that combines microneedling with drug delivery, and it could be used to deliver IL TAC to AA patients. This technique promotes a more uniform absorption of corticosteroids than traditional treatment methods of AA.

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“…These GF seem to act in the bulb of the follicle joining to primitive stem cell receptors to activate the proliferative phase of the hair, originating a new follicular unit, maybe through the extracellular signal‐regulated kinase pathway. Additionally, human dermal papilla cells increased their growth rate when they were cultured with PRP, therefore PRP may be involved in the stimulation of cell growth in the hair follicle (Gkini et al, ; Khatu et al, ) (Strazzulla, Avila, Lo Sicco, & Shapiro, ).…”

Section: The Prp In Dermatologymentioning

confidence: 99%

Platelet‐rich plasma, a powerful tool in dermatology

Merchán

Gómez

Chasoy

et al. 2019

J Tissue Eng Regen Med

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Platelet‐rich plasma (PRP), a platelet concentrate contained in a small volume of plasma, has become a promising option in the last decade to treat different diseases related to the skin due to its high concentration of growth factors. When it is of autologous origin, it decreases the probability of suffering adverse reactions and transfusion‐transmitted infections, thus it is an optimal and safe therapy for the patient. PRP has been used in the treatment of several dermatological conditions such as acne, alopecia, and skin ulcers. Its use has also extended to other skin conditions such as melasma, hyperpigmentation, and burns, where it stimulates tissue repair and regeneration. The purpose of this article is to review the management and treatment of different dermatological alterations with PRP. Although there are a variety of studies that support the use of PRP, more research is needed to standardise the protocols for obtaining, processing, and applying it as well as understanding the biological and molecular bases of its functioning.

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An Overview of the Biology of Platelet-Rich Plasma and Microneedling as Potential Treatments for Alopecia Areata

Cited by 20 publications

References 26 publications

Platelet factor 4 inhibits human hair follicle growth and promotes androgen receptor expression in human dermal papilla cells

Platelet factor 4 inhibits human hair follicle growth and promotes androgen receptor expression in human dermal papilla cells

Successful Treatment of Alopecia Areata Patches with Triamcinolone Acetonide Using MMP®: Report of 2 Cases

Platelet‐rich plasma, a powerful tool in dermatology

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