An overview of the biochemistry, synthesis, modification, and evaluation of mucoadhesive polymeric nanoparticles for oral delivery of bioactive compounds

Wang, Taoran; Fleming, Erika; Luo, Yangchao

doi:10.1007/s42114-022-00586-0

Cited by 24 publications

(13 citation statements)

References 176 publications

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“…Key factors influencing antimicrobial and anti-biofilm activity are polymer choice and method of synthesis. These may affect the shape, size and surface properties, which in turn may influence the activity . Polymeric NPs have been shown to exhibit potent antibacterial and anti-biofilm activity against Gram-positive and Gram-negative bacteria .…”

Section: Nanotechnological Approaches For Biofilm Controlmentioning

confidence: 99%

Advances in Nanotechnology for Biofilm Inhibition

et al. 2023

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Biofilm-associated infections have emerged as a significant public health challenge due to their persistent nature and increased resistance to conventional treatment methods. The indiscriminate usage of antibiotics has made us susceptible to a range of multidrug-resistant pathogens. These pathogens show reduced susceptibility to antibiotics and increased intracellular survival. However, current methods for treating biofilms, such as smart materials and targeted drug delivery systems, have not been found effective in preventing biofilm formation. To address this challenge, nanotechnology has provided innovative solutions for preventing and treating biofilm formation by clinically relevant pathogens. Recent advances in nanotechnological strategies, including metallic nanoparticles, functionalized metallic nanoparticles, dendrimers, polymeric nanoparticles, cyclodextrin-based delivery, solid lipid nanoparticles, polymer drug conjugates, and liposomes, may provide valuable technological solutions against infectious diseases. Therefore, it is imperative to conduct a comprehensive review to summarize the recent advancements and limitations of advanced nanotechnologies. The present Review encompasses a summary of infectious agents, the mechanisms that lead to biofilm formation, and the impact of pathogens on human health. In a nutshell, this Review offers a comprehensive survey of the advanced nanotechnological solutions for managing infections. A detailed presentation has been made as to how these strategies may improve biofilm control and prevent infections. The key objective of this Review is to summarize the mechanisms, applications, and prospects of advanced nanotechnologies to provide a better understanding of their impact on biofilm formation by clinically relevant pathogens.

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Section: Nanotechnological Approaches For Biofilm Controlmentioning

confidence: 99%

Advances in Nanotechnology for Biofilm Inhibition

et al. 2023

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“…By capitalizing on the unique properties of polymeric nanoparticles, researchers aim to overcome the challenges associated with oral drug delivery, such as enzymatic degradation and limited absorption. 54 It seems as though the future of biopolymer application is to use various polymer combinations to develop hybrid polymers that have a better specificity profile for specific biomedical applications, be such as tissue engineering, drug delivery, or wound healing. This is in contradiction to trying to categorize specific polymers for specific biomedical applications.…”

Section: Biopolymers For Bone Tissue Engineeringmentioning

confidence: 99%

Polymer-ceramic composites for bone challenging applications: Materials and manufacturing processes

Monia,

Ridha

2023

Journal of Thermoplastic Composite Materials

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The continuous advancement of bone restoration technologies is crucial for the creation of innovative materials that possess enhanced functional and technological capabilities. One promising area of research focuses on the development of composite materials combining polymers and ceramics for bone regeneration. These materials offer several advantages over traditional bone grafting materials, including the ability to be customized to meet the specific needs of individual patients and a reduced risk of disease transmission. In recent years, significant progress has been made in the development of polymer-ceramic biomaterials with improved capacities for bone regeneration. This progress has primarily concentrated on enhancing mechanical properties, biodegradability, and biocompatibility. The objective of this overview is to present the latest advancements in composite ceramic polymers used for bone regeneration, encompassing the corresponding manufacturing processes as well as the materials employed in these biomaterials.

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“…Mucoadhesive polymers are materials with intrinsic mucoadhesive properties [ 20 ]. Fully synthetic polymeric nanocarriers were also tested with significant results [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

“…Mucoadhesive polymers are materials with intrinsic mucoadhesive properties [ 20 ]. Fully synthetic polymeric nanocarriers were also tested with significant results [ 20 , 21 ]. Chitosan ( CHI ) is a natural, biocompatible, and biodegradable polymer that is derived from chitin, which is found in the exoskeleton of crustaceans.…”

Section: Introductionmentioning

confidence: 99%

Crosslinked Chitosan Nanoparticles with Muco-Adhesive Potential for Intranasal Delivery Applications

Gagliardi

Chiarugi

Cesari

et al. 2023

IJMS

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Intranasal drug delivery is convenient and provides a high bioavailability but requires the use of mucoadhesive nanocarriers. Chitosan is a well-established polymer for mucoadhesive applications but can suffer from poor cytocompatibility and stability upon administration. In this work, we present a method to obtain stable and cytocompatible crosslinked chitosan nanoparticles. We used 2,6-pyridinedicarboxylic acid as a biocompatible crosslinker and compared the obtained particles with those prepared by ionotropic gelation using sodium tripolyphosphate. Nanoparticles were tested to evaluate the size and the surface charge, as well as their stability in storage conditions (4 °C), at the nasal cavity temperature (32 °C), and at the body temperature (37 °C). The crosslinked chitosan nanoparticles showed a size around 150 nm and a surface charge of 10.3 mV ± 0.9 mV, both compatible with the intranasal drug administration. Size and surface charge parameters did not significantly vary over time, indicating the good stability of these nanoparticles. We finally tested their cytocompatibility in vitro using SHSY5Y human neuroblastoma and RPMI 2650 human nasal epithelial cells, with positive results. In conclusion, the proposed synthetic system shows an interesting potential as a drug carrier for intranasal delivery.

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An overview of the biochemistry, synthesis, modification, and evaluation of mucoadhesive polymeric nanoparticles for oral delivery of bioactive compounds

Cited by 24 publications

References 176 publications

Advances in Nanotechnology for Biofilm Inhibition

Advances in Nanotechnology for Biofilm Inhibition

Polymer-ceramic composites for bone challenging applications: Materials and manufacturing processes

Crosslinked Chitosan Nanoparticles with Muco-Adhesive Potential for Intranasal Delivery Applications

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