2017
DOI: 10.1017/s1041610217002344
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An overview of systematic reviews of pharmacological and non-pharmacological interventions for the treatment of behavioral and psychological symptoms of dementia

Abstract: Background: This systematic overview reports findings from systematic reviews of randomized controlled trials of pharmacological and non-pharmacological interventions for behavioural and psychological symptoms of dementia (BPSD).

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Cited by 259 publications
(228 citation statements)
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“…While there are pharmacologic interventions to clearly improve psychosis and aggressive symptoms, nonpharmacologic interventions for patients and their caregivers might have also improved their depressive mood or emotional withdrawal, which may, in turn, decrease overall NPS severity. [27][28][29] When treating NPSs with antipsychotics, which target psychosis or aggression, clinicians may also need to pay attention to motivational and emotional problems and monitor early cognitive declines.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…While there are pharmacologic interventions to clearly improve psychosis and aggressive symptoms, nonpharmacologic interventions for patients and their caregivers might have also improved their depressive mood or emotional withdrawal, which may, in turn, decrease overall NPS severity. [27][28][29] When treating NPSs with antipsychotics, which target psychosis or aggression, clinicians may also need to pay attention to motivational and emotional problems and monitor early cognitive declines.…”
Section: Discussionmentioning
confidence: 99%
“…Third, the influence of medication dosage was not taken into account since flexible dosing was employed in the original CATIE-AD study. 13 Fourth, the antidepressant or anticonvulsant effectiveness for overall NPSs has been shown in a recent systematic review, 28 but we did not include concomitant medications (ie, psychotropics, anticholinesterase drugs, or antihypertensive drugs) prior to the trial initiation as confounding factors in the present study. Although they may have influence as clinical predictors of subsequent response, we found no relationship between concomitant medications and subsequent treatment response in the previous reports of the CATIE-AD study.…”
Section: Limitationsmentioning
confidence: 99%
“…For example, what is included in "music therapy" (Dyer et al, 2017)? Does it include listening to music via headphones?…”
Section: What Is a Non-pharmacological Intervention?mentioning
confidence: 99%
“…[2][3][4] Current evidence suggests that people with mild to moderate AT dementia are most likely to benefit from CEIs; however, those with severe dementia and other types of dementia can also benefit. [2][3][4] Current evidence suggests that people with mild to moderate AT dementia are most likely to benefit from CEIs; however, those with severe dementia and other types of dementia can also benefit.…”
mentioning
confidence: 99%
“…dementia and may reduce behavioural and psychological symptoms of dementia (BPSD). [2][3][4] Current evidence suggests that people with mild to moderate AT dementia are most likely to benefit from CEIs; however, those with severe dementia and other types of dementia can also benefit. Memantine can be added to CEIs or used in people with more advanced dementia.…”
mentioning
confidence: 99%